Clinical trials: Xerostomia
Oral Complications, Quality of Life
Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids
RATIONALE: Pilocarpine may help to relieve dry mouth in patients receiving opioids for cancer therapy. It is not yet known whether pilocarpine is more effective than no further treatment for this condition.
- Trial name
- NCT00003686
- Testing
- pilocarpine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- NCIC Clinical Trials Group
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
To evaluate the safety of UTAA09 injection in the treatment of relapsed/refractory (R/R) autoimmune disease (AID). To evaluate the pharmacokinetic (PK) profile of UTAA09 injection in patients with R/R AID.
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjogren's Syndrome
- Trial name
- NCT06417398
- Testing
- T cell injection targeting CD19 chimeric antigen receptor
- Volunteers
- 10 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Sjogren's Syndrome
Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome.
- Trial name
- pSS (NCT03711214)
- Testing
- Periodontal scaling
- Where
- 3 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
SARS-CoV Infection, Systemic Disease
Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases
An observational study aiming to assess the serological profile of SARS-Cov2 patients with systemic diseases such as systemic lupus erythematosus, Sjogren syndrome, sarcoidosis, inflammatory myopathies, Behçet's disease…
- Conditions
- SARS-CoV Infection, Systemic Disease, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT04530461
- Testing
- Serological test
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- faida agili
Xerostomia, Head and Neck Cancer
Blinded Dry Mouth Spray Crossover Study
To identify the effectiveness of two mouth sprays at relieving symptoms of xerostomia in patients who have received radiation for carcinoma of the head and neck.
- Conditions
- Xerostomia, Head and Neck Cancer, Xerostomia Following Radiotherapy
- Trial name
- NCT04608773
- Testing
- Remineralizing Extreme Dry Mouth Spray with Xylitol, Alcohol-Free Moisturizing Dry Mouth Spray
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Jonas Johnson
Head and Neck Cancer
Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.
The purpose of the study is to evaluate the effectiveness of low level laser on radiotherapy induced xerostomia to improve oral function and decrease oral complication due to hyposalivation and thus enhancing survival.
- Trial name
- NCT04700475
- Testing
- low level laser, citric acid solution
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nada Yousef
Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer
Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial
Nasopharyngeal carcinoma (NPC) is the highest reported otorhinolaryngological malignancy reported in Malaysia affecting predominantly male adults between 40-60 years old [1, 2].
- Trial name
- NCT04491435
- Testing
- Summated Xerostomia Inventory, Sialometry
- Where
- Malaysia
- Volunteers
- 94 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Major Abdominal Surgeries
Cold Water Gargling After Major Abdominal Surgery
This randomized controlled trial examined the effect of cold water gargling on postoperative oral dryness, thirst severity, and patient satisfaction in patients who underwent major abdominal surgery.
- Trial name
- NCT07506226
- Testing
- Cold water gargling
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- TC Erciyes University
Dry Eye Disease, Xerostomia
Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness
Dry Eye Disease (DED) is a multifactorial pathology characterized by inflammation of the lacrimal functional unit that develops in ocular surface pathology, severely affecting patients quality of life.
- Trial name
- NCT05187533
- Testing
- Osteopathic protocol of Sphenopalatine Ganglion Stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Dry Eye Syndromes, Sjogren's Syndrome
Effects of Sustained Reading on the Ocular Surface
This research is being done to to see if changes in visual reading function correlate with changes in optical and retinal image quality.
- Trial name
- NCT02031172
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Sjogren's Disease
Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease
This aim of this study is to compare the reproducibility of reading of five international experts concerning the anomalies of the salivary glands. The reproducibility is measure on patients and not on recorded data.
- Trial name
- ETREINTE (NCT02358213)
- Testing
- Ultrasound
- Volunteers
- 21 people
- Sponsor
- University Hospital, Brest
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Dental Plaque, Pus Collection
Regular Antibacterial Photodynamic Therapy on Oral Hygiene in Elderly Residents
Around 40 people will participate in the study. The study participants will be recruited from service homes in the City of Helsinki. The subjects will be randomized into two groups.
- Conditions
- Dental Plaque, Pus Collection, Oral Disease, Dryness Oral
- Trial name
- NCT05853679
- Testing
- Lumoral Treatment, Standard oral hygiene instructions according to the Finnish Dental Association
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Koite Health Oy
Saliva Altered
Application of Neuro-electrostimulation as a Treatment for Patients With Dry Mouth
Hyposalivation is a condition that has increased in frequency, primarily due to the degeneration of salivary glands caused by aging, polypharmacy, chronic or autoimmune diseases, or radiation treatments.
- Trial name
- NCT07593495
- Testing
- electrotherapy and physical therapy device
- Where
- Mexico
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma del Estado de Mexico
Xerostomia
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
This study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect…
- Trial name
- NCT04392622
- Testing
- D-Limonene Gelcaps, Intensity modulated radiotherapy (IMRT), Cisplatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Sjogren Syndrome, Xerostomia
Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome
This study will evaluate the effects of exosome and mesenchymal stem cell injections into the submandibular glands of adults with primary Sjögren syndrome and salivary gland dysfunction or dry mouth.
- Conditions
- Sjogren Syndrome, Xerostomia, Exosome
- Trial name
- NCT07838454
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Banu Erkal
Xerostomia
Effectiveness of Thyme Honey in Management of Xerostomia in ESRD
The oral health of older people has warranted considerable research attention in the last two to three decades. One of the most oral conditions that have been related to the elderly patients was xerostomia.
- Trial name
- NCT05247008
- Testing
- Thyme honey
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University