Clinical trials: Young Adults
Relapsed Acute Lymphoblastic Leukemia (ALL)
CAR-T Cell Therapy for ALL
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and the second most frequent acute leukemia in adults. B-cell ALL constitutes approximately 85% of all ALL diagnoses.
- Trial name
- PAKCAR-ALL (NCT07695012)
- Testing
- CAR-T cell infusion
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Dr. Zaineb Akram
Brown Fat
Efficacy of Pharmacological Stimulation of BAT and WAT in Lean and Obese Young Adults
To determine whether pharmacological stimulation of supraclavicular Brown Adipose Tissue (BAT or "Brown Fat") and subcutaneous White Adipose Tissue (WAT) using an FDA-approved beta3 agonist is as effective in increasing oxidative…
- Trial name
- MiraBAT (NCT02354807)
- Testing
- Mirabegron, Cold exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Otto Muzik
Neuroblastoma
Horse Therapy for Children, Adolescents and Young Adults in Remission From Medulloblastoma
On average, each year in the former region, 60 new patients under the age of 18 are treated for a brain tumor, with an active post-treatment follow-up file of 350 patients.
- Trial name
- EQUI-HIPPO (NCT05755295)
- Testing
- horse therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
BDNF, Irisin
The Acute Effect of Different Resistance Exercise Loads on Irisin and Brain-derived Neurotrophic Factor in Blood Serum and Plasma
The aim of this study is to investigate different resistance training loads on BNDF and irisin levels in platelets, blood serum and plasma.
- Conditions
- BDNF, Irisin, Resistance Exercise, Stroop Test
- Trial name
- NCT07189130
- Testing
- Exercise: 80% 1 RM with 2 minutes break, Exercise: 80% 1RM with1 minute break, Exercise: accenuated eccentric exercise
- Where
- Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Diabetes, Endocrine System Diseases
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to…
- Conditions
- Diabetes, Endocrine System Diseases, Gastro-Intestinal Disorder, Neuro-Degenerative Disease
- Trial name
- TNT (NCT03342495)
- Testing
- Patient Navigator, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 337 people
- Sponsor
- University of Calgary
Influenza
Safety and Immunogenicity Study of a Booster Vaccination With a Non-Adjuvanted H5N1 Influenza Vaccine (Follow Up to Study 810501)
The purpose of this Phase II follow-up study (to study 810501) is to assess the immunogenicity and safety of a booster vaccination with a non-adjuvanted H5N1 influenza vaccine administered 12 to 17 months after a two-dose regimen…
- Trial name
- NCT00530660
- Testing
- H5N1 influenza vaccine (whole virion, Vero cell-derived), 7.5 µg HA antigen, non-adjuvanted
- Where
- Austria
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Cervical Cancer, Vulvar Cancer
Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004)
This study will assess the safety and immunogenicity of GARDASIL®9 (V503) in 16- to 45-year-old women. The primary hypothesis of the study states that anti-HPV 16, 18, 31, 33, 45, 52, and 58 geometric mean titers (GMTs) at 4…
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, Genital Warts
- Trial name
- NCT03158220
- Testing
- V503
- Where
- 24 sites in Austria, Belgium and 4 more
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Wellbeing, Mental Disorder
App-based Mental Health Promotion in Young European Adults
The ECoWeB Project aims to develop and disseminate a mobile application (App) to provide engaging and personalized tools and psychological skills to promote emotional wellbeing and prevent mental health problems in adolescents…
- Trial name
- ECoWeB (NCT04148508)
- Testing
- Tailored Emotional Competence Self-help, Cognitive-behavioural Approach, Self-monitoring
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 3,794 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Hamstring Muscle Tightness
Virtual Reality in Sedentary Adults With Hamstring Shortening
Tightness of hamstring muscle is known as a reduction in range of motion accompanied by a sensation of restriction in the posterior aspect of thigh.
- Trial name
- NCT07238491
- Testing
- Virtual reality, Traditional physical therapy programme
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- Cairo University
Postmenopausal, Prediabetes
Glucose-Guided Eating Pilot
This is a single center, parallel-arm randomized controlled pilot study that aims to examine the feasibility and acceptability of the glucose-guided eating (GGE) mobile app and intervention in two populations at risk of chronic…
- Conditions
- Postmenopausal, Prediabetes, Adolescent and Young Adult (AYA) Cancer Survivors
- Trial name
- GET CHARGED (NCT05998460)
- Testing
- Glucose-Guided Eating with CGM, CGM only
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Cardiopulmonary Diseases
Indoor Air Filtration and Young Adults Health Study
This study aims to explore the cardiopulmonary health effects of indoor air purification and other indoor environmental conditions among young healthy college students in Beijing, China.
- Trial name
- NCT05172388
- Testing
- Air purifier
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Peking University
Pediatric Cancer
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This proof-of-concept platform trial is designed to cover the targeting of several survival pathways in oncogenesis that are currently not adequately employed for pediatric patients in Europe (Geoerger 2017; Geoerger 2019).
- Trial name
- ESMART (NCT02813135)
- Testing
- Ribociclib, Topotecan, Temozolomide
- Where
- 23 sites in Denmark, France and 4 more
- Volunteers
- 472 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cancer, Breast Cancer
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended…
- Conditions
- Cancer, Breast Cancer, Colorectal Cancer, Sarcoma
- Trial name
- AYA STEPS (NCT06371768)
- Testing
- AYA Educational Information, AYA STEPS
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Duke University
Neuroblastoma, Ewing Sarcoma
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors.
- Conditions
- Neuroblastoma, Ewing Sarcoma, Osteosarcoma, Rhabdomyosarcoma
- Trial name
- NCT06541262
- Testing
- Silmitasertib, Irinotecan, Temozolomide
- Where
- 24 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Milton S. Hershey Medical Center
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Locally Advanced Solid Tumors, Metastatic Solid Tumors
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring anaplastic lymphoma kinase (ALK), receptor…
- Conditions
- Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors
- Trial name
- NCT04094610
- Testing
- Oral repotrectinib (TPX-0005)
- Where
- 68 sites in United States, Australia and 9 more
- Volunteers
- 75 people
- Sponsor
- Turning Point Therapeutics, Inc.
Non-athletic Active Young Adults
Effect of Short Sprint Interval Training With Active Recovery as Compared to Passive Recovery on Anaerobic Capacity in Non-athletic Population
Short Sprint Interval Training (SSIT) is a modified form of Sprint Interval Training (SIT) defined as "small bouts of supramaximal exercise with recovery periods between them to increase peak oxygen uptake in spite of having a…
- Trial name
- NCT06625424
- Testing
- Short Sprint Interval Training with passive recovery, Short Sprint Interval Training with Active Recovery
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Behaviour Change
Targeted Vs Generic Print Materials on Physical Activity and Quality of Life in Young Adult Cancer Survivors
Young adult cancer survivors (YACS) are an understudied group in cancer survivorship research that have unique psychosocial, medical and survivorship issues.
- Trial name
- NCT05450315
- Testing
- Stride to Survive:An Exercise Guide for Young Adult Cancer Survivors, Canadian Physical Activity Guidelines
- Where
- Canada
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy
Metabolic Availability of Lysine From Barley in Young Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03907020
- Testing
- Barley
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Binge-Eating Disorder
Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities.
- Trial name
- NCT04125589
- Testing
- Speaking Activity, Talking Activity
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
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