Clinical trials: Zika Virus Infection
Travel-Related Illness, Malaria
Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and Malaria
The investigators hypothesize that sex, age, area of exposure and purpose of travel are associated with different travel-related infections. The investigators also hypothesize that certain infections will have long-term sequelae.
- Conditions
- Travel-Related Illness, Malaria, Dengue, Chikungunya
- Trial name
- ITIT (NCT04672577)
- Testing
- Observational study
- Where
- Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Patricia Schlagenhauf
Zika Virus Infection
Safety and Immunogenicity of BBV121
To evaluate the safety, tolerability, and immunogenicity of two-doses of three-sequentially escalating cohort (2.5 µg, 5 µg and 10 µg) of BBV121 (purified inactivated adsorbed Zika virus vaccine) compared with Placebo (Alum).
- Trial name
- Zika (NCT04478656)
- Testing
- BBV121
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
Dengue, Zika Virus Infection
Applying Wolbachia to Eliminate Dengue
This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia
- Conditions
- Dengue, Zika Virus Infection, Chikungunya Fever
- Trial name
- AWED (NCT03055585)
- Testing
- Wolbachia-infected Aedes aegypti mosquitoes, standard practice dengue control
- Where
- Indonesia
- Volunteers
- 8,173 people
- Sponsor
- Gadjah Mada University
Encephalitis, Myelitis
Neurologic Manifestations of the Arbovirus Infection in Colombia
This is a multi-center case-control study that aims to define the association between the exposure to an arbovirus infection and the development of a neurological syndrome in patients from Colombia.
- Conditions
- Encephalitis, Myelitis, Guillain-Barre Syndrome, Cranial Nerve Palsies
- Trial name
- NCT03206541
- Where
- 8 sites in Colombia
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Zika Virus, Zika Virus Infection
Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults
In this Phase 1 study, two target dose levels of VLA1601, a purified, inactivated, whole Zika virus (ZIKV) vaccine candidate adsorbed on aluminum hydroxide (alum) will be evaluated: 6 antigen units (AU) and 3 AU of inactivated…
- Trial name
- NCT03425149
- Testing
- VLA1601
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Zika Virus Infection, Microcephaly
Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome
Microcephaly associated with Congenital Syndrome of the Zika virus (SCVZ) was highlighted due to atypical structural and behavioral changes of the central nervous system.
- Trial name
- NCT03330600
- Testing
- aquatic physicotherapy, immersion
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Universidade Federal de Pernambuco
Treatment of Acute Zika Virus Infection
Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans
Zika virus (ZIKV) infection is a new emerging arbovirus disease, caused by the same vector that transmits Dengue virus, Aedes aegypti.
- Trial name
- NCT03443830
- Testing
- Tyzivumab
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tychan Pte Ltd.
Zika Virus, Dengue Virus
Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)
Background: Zika virus is mostly passed on by the bite of an infected mosquito. It usually causes mild illness. But in pregnant women it can cause serious birth defects to the baby.
- Conditions
- Zika Virus, Dengue Virus, Chikungunya Virus Infections
- Trial name
- NCT02794181
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Zika Virus Symptoms and the Associated Exanthema
Dermatologic Manifestations of Zika Virus
The purpose of this study is to determine whether any diagnostic patterns exist in the symptom presentation of Zika Virus.
- Trial name
- DMZV (NCT03229421)
- Testing
- Survey
- Where
- Dominican Republic
- Sponsor
- Northwestern University
Zika Virus Infection
Evaluation of the Clinical Performance of the ZIKV Detect™ 2.0 IgM Capture ELISA
The purpose of this study is to evaluate the performance of the ZIKV Detect™ 2.0 IgM Capture ELISA using archived confirmed ZIKV positive and confirmed ZIKV negative human serum samples.
- Trial name
- NCT03776903
- Testing
- ZIKV Detect™ 2.0 IgM Capture ELISA
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- InBios International, Inc.
Zika Virus Infection
Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection
Introduction: It is estimated that more than one million Brazilians were infected by zika virus in the last two years. Brazilian researchers first noted the virus's potential association with microcephaly.
- Trial name
- NCT03679728
- Testing
- First trimester, Second trimester
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Zika
Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study
This is a phase 1 trial of one or more administrations of Zika Virus Purified Inactivated Vaccine (ZPIV). The trial will be conducted under a placebo controlled, double-blind, randomized allocation of study product.
- Trial name
- Z001 (NCT02937233)
- Testing
- Zika Virus Purified Inactivated Vaccine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kathryn Stephenson
Zika Virus
Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection
In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection.
- Trial name
- NCT02979938
- Testing
- Semen analysis and semen PCR for Zika virus
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- Trinidad and Tobago IVF and Fertility Centre
ZIKA VIRUS INFECTION, Child Development
Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
The recent increase in the number of cases of congenital microcephaly observed in Brazil is a reason of great concern. This increase occurred a few months after Zika virus (ZIKV) was introduced in the country, which was…
- Conditions
- ZIKA VIRUS INFECTION, Child Development, Microcephaly
- Trial name
- ZIKVIRUSIFF (NCT03255369)
- Testing
- Child exposed Zika virus proved
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Oswaldo Cruz Foundation
Zika Virus
Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome
Congenital Zika virus syndrome (SCZv) has been gaining attention in studies due to changes in the central nervous system and in the motor development of children.
- Trial name
- NCT03227601
- Testing
- posture adapter
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Tropical Disease
A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru
Tropical diseases are continuously on the rise throughout the world as they are spreading and manifesting in various locations globally.
- Trial name
- NCT03078894
- Testing
- Zika, Chikagunya, Dengue
- Where
- 4 sites in Peru
- Volunteers
- 100 people
- Sponsor
- BioRed LLC
Microcephaly
Zika and Microcephaly: Case-control Study
It is suspected that zika virus infection during pregnancy is associated with microcephaly. The objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during…
- Trial name
- NCT02741882
- Testing
- Questionary
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Laboratório Sabin
Healthy Children
Parental Views Related to Colorado State Legislation About Vaccinations, Schools, and Child Care Centers
Through an online survey, participants will be shown different visual presentations of vaccination data related to schools and child care centers.
- Trial name
- NCT02957344
- Where
- United States
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver