Clinical trials: a Randomized Controlled Trial
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Lumbar Spinal Fusion
Ketorolac Effects on Post-operative Pain and Lumbar Fusion
A double blind prospective randomized trial of IV ketorolac vs. placebo in management of patients undergoing lumbar one or two level spinal fusions.
- Trial name
- NCT06513208
- Testing
- Ketorolac Tromethamine
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Maryland St. Joseph Medical Center
Threatened Abortion
Oral Progesterone for Prevention of Miscarriage in Threatened Abortion
This study evaluates the effectiveness of oral dydrogesterone in preventing miscarriage in threatened abortion. Half of participants will receive oral dydrogesterone, while the other half will receive oral placebo.
- Trial name
- NCT04788108
- Testing
- Dydrogesterone
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Class II Malocclusion, Division 1
Pain, Discomfort, and Acceptance During Using Electrical Stimulation to Accelerate Orthodontic Teeth Movement
Forty patients with class II division 1 malocclusion who will require extraction of the upper first premolars as a part of the orthodontic treatment plan will be invited to participate in the study.
- Trial name
- NCT05920525
- Testing
- Electrical stimulation, Traditional retraction of the front upper teeth
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Obesity, Overweight
Soy Fiber Improves Weight Loss and Lipid Profile
The aim of this study is to examine the effects of soy fiber on body weight, body composition and blood lipids in overweight and obese participants.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT01802840
- Testing
- biscuits supplemented with soy fiber
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Zhejiang University
Dental Implants
Dynamic Navigation vs. the Freehand Method
The purpose of the study is to evaluate in novice surgeons the accuracy of the X-Guide® navigation system (X-Guide®, X-Nav Technologies®, Pennsylvania, USA) in implant placement compared to freehand implant placement.
- Trial name
- NCT06028750
- Testing
- Dynamic Computer Assisted Surgery, Freehand
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Pneumonia, Diagnosis
Metagenomic NGS for Diagnosis of Pneumonia
In this randomized controlled trial, we aim to evaluate the efficacy of incorporating mNGS in the management of pneumonia on efficiency and accuracy of causative pathogen identification, proportion of participants with effective…
- Trial name
- NCT05979350
- Testing
- Metagenomic next-generation sequencing, Standard work-up for pneumonia
- Where
- Taiwan
- Volunteers
- 114 people
- Sponsor
- National Taiwan University Hospital
Music Therapy, Perioperative Care
Effect of Music in Intraoperative Period
Background and Aims: Music therapy has a wide range of uses in health care practice. The aim of this study was to investigate the effects of intraoperative music played during spinal anesthesia operation on the patients'…
- Conditions
- Music Therapy, Perioperative Care, Postoperative Pain, Anxiety
- Trial name
- NCT04485650
- Testing
- music therapy, sedated group, non-sedated group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Aging
The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics
The goal of this clinical trial is to assure the safety of long term therapeutic plasma exchange (TPE) with and without Intravenous Immunoglobulin (IVIG) and its effects on biomarkers and epigenetic biologic clocks in forty…
- Trial name
- NCT06534450
- Testing
- Therapeutic Plasma Exchange, IVIG
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dobri Kiprov
Weight Gain
Growth and Safety Clinical Trial on a New Infant Formula
The aim of this study is to assess age-appropriate growth of healthy infants fed a new infant formula. In this randomized, controlled trial, healthy, term, formula-fed infants will be randomized to one of two infant formulas: a…
- Trial name
- NCT05508750
- Testing
- New Infant Formula, Commercial Infant Formula
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Jovie USA, LLC
Female Sexual Dysfunction (FSD), Pelvic Floor Muscle Training
Effects of Extracorporeal Shockwave Therapy Versus Pulsed Electromagnetic Field Therapy in Females With Sexual Dysfunction.
This is a prospective, three-arm, parallel-group, assessor-blinded randomized controlled trial designed to compare the effectiveness of extracorporeal shockwave therapy (ESWT) combined with pelvic floor muscle training (PFMT)…
- Conditions
- Female Sexual Dysfunction (FSD), Pelvic Floor Muscle Training, Shock Wave, Pulsed Electromagnetic Therapy
- Trial name
- NCT07584174
- Testing
- low-intensity extracorporeal shockwave therapy, Pulsed electromagnetic field stimulation, Pelvic floor muscle training
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Benha University
Acute Bacterial Skin and Skin Structure Infection (ABSSSI), Prosthetic Joints Infection (PJI)
Phase 1, Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants
This is a phase 1, single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical trial of single and multiple intravenous doses of TNP-2092 for injection in healthy Chinese participants.
- Trial name
- NCT06394518
- Testing
- TNP-2092 for injection
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics Inc.
Psoriasis Vulgaris
Efficacy and Safety of Novel Formulations of Topical Calcipotriol in Patients With Mild to Moderate Plaque Psoriasis
This was a Phase I, single-center, randomized, controlled trial to evaluate the antipsoriatic efficacy of calcipotriol in novel formulations based on AKVANO technology as compared to marketed calcipotriol products (Daivonex®…
- Trial name
- AKVANO-AKP01 (NCT05488990)
- Testing
- AKVANO-Calcipotriol formulation 1, AKVANO-Calcipotriol formulation 2, AKVANO vehicle formulation 1
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Lipidor AB
Diverticulitis, Acute Diverticulitis
Randomized Multicentric Trial to Evaluate a Free Diet With a Progressive Diet in the Treatment of Acute Diverticulitis (DIVERDIET)
Phase III trial is designed to demonstrate the non-inferiority of a free diet versus a progressive diet in the treatment of acute diverticulitis (AD) without complications.
- Conditions
- Diverticulitis, Acute Diverticulitis, Diverticulitis, Colonic, Uncomplicated Diverticular Disease
- Trial name
- NCT03496090
- Testing
- Free diet, Progressive diet
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Hospital General Universitario Reina Sofía de Murcia
Interstitial Cystitis, Painful Bladder Syndrome
Amniotic Membrane Therapy for Interstitial Cystitis/Painful Bladder Syndrome
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a clinical syndrome in which patients report symptoms of bladder and/or pelvic pain with pressure and/ or discomfort associated with urinary frequency and urgency.
- Conditions
- Interstitial Cystitis, Painful Bladder Syndrome, Painful Bladder Syndrome (PBS)
- Trial name
- NCT06096597
- Testing
- Clarix Flo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- David Sheyn
Kidney Cancer
Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal Tumors
The goal of this clinical trial is to learn if ursodeoxycholic acid, also called UDCA, can help protect kidney function in adults undergoing partial nephrectomy for kidney tumors.
- Trial name
- PURIFY (NCT07672860)
- Testing
- UDCA (Ursodeoxycholic acid)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Jinling Hospital, China
Atrial Fibrillation (AF), Catheter Ablation
Effects of Music During Atrial Fibrillation Ablation Under Conscious Sedation
I. Background Atrial fibrillation, a common type of arrhythmia, is often treated with radiofrequency catheter ablation, a minimally invasive procedure that helps restore a normal heart rhythm.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Pain Management
- Trial name
- NCT06953752
- Testing
- Music intervention, Control
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shaoxing People's Hospital
Compliant Behavior, Diarrheal Disease
Rural China Electric Kettle Promotion Program
This study will evaluate the impact of a pilot Rural Electric Kettle Promotion Program offered to low-income households in rural Anhui Province, China.
- Conditions
- Compliant Behavior, Diarrheal Disease, Pollution; Exposure
- Trial name
- NCT03376152
- Testing
- Electric Kettle Promotion
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Heart Transplant Infection, CMV Infection
Multicenter Clinical Trial to Evaluate the Efficacy of a Preventive Strategy Against CMV Infection in Heart Transplant Patients, Based on the Specific T Cells Response
This study evaluates the efficacy and safety of an individualized preventive strategy against CMV infection in CMV seropositive heart transplant patients based on the specific basal response of the lymphocytes againts CMV…
- Trial name
- ELISPOT-TC (NCT04278547)
- Testing
- ELISPOT IFN-γ assay
- Where
- Spain
- Volunteers
- 188 people
- Sponsor
- Hospital Universitari de Bellvitge
Hepatitis C
Study of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Japanese Participants With Chronic Hepatitis C (MK-5172-058)
This is a two-part study of grazoprevir (MK-5172) + elbasvir (MK-8742) in Japanese participants with chronic hepatitis C virus (HCV) genotype 1 (GT1).
- Trial name
- NCT02203149
- Testing
- Grazoprevir, Elbasvir
- Volunteers
- 399 people
- Sponsor
- Merck Sharp & Dohme LLC