Clinical trials: acne, open to volunteers
Isotretinoin, Isotretinoin Adverse Reaction
Expert Consensus on the Use of Isotretinoin in Acne Vulgaris: A Delphi Study
This study is a Delphi-based expert consensus project designed to establish evidence-informed, practical recommendations for the use of isotretinoin in acne vulgaris.
- Conditions
- Isotretinoin, Isotretinoin Adverse Reaction, Acne
- Trial name
- NCT07296523
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Venus Research Center
Acne Vulgaris on the Face
Efficacy and Tolerability of DispersinB Acne Cleanser in the Treatment of Mild to Moderate Acne Vulgaris
This is a single-center study using intra-individual comparison (right half-face versus left half-face) to evaluate the efficacy and tolerability of DispersinB Acne Cleanser for treatment of acne in adults.
- Trial name
- NCT06729450
- Testing
- DispersinB Acne Cleanser
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kane Biotech Inc
Acne
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
The purpose of the trial is to evaluate the safety, efficacy and immunogenicity of up to 3 intramuscular injections of the Acne mRNA vaccine candidate at up to four dose levels in adult participants aged 18 to 45 years with…
- Trial name
- NCT06316297
- Testing
- Acne mRNA vaccine
- Where
- 94 sites in United States, Australia and 2 more
- Volunteers
- 800 people
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Acne Vulgaris
The Relationship Between Microbioma Balance and Acne Vulgaris as a New Acne Treatment
Background: Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes, which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism.
- Trial name
- NCT06925386
- Testing
- Standard therapy, HEXBIO, Secretome
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Universitas Padjadjaran
Acne
Role of Akkermansia Muciniphila in Acne Vulgaris
The project explores the use of Pendulum's Glucose Control, which contains a unique combination of probiotics, including Akkermansia muciniphila, Clostridium beijerinckii, Anaerobutyricum hallii, Clostridium butyricum, and…
- Trial name
- NCT06992154
- Testing
- Akkermansia Muciniphila, Clostridium Beijerinckii, Anaerobutyricum Hallii, Clostridium Butyricum, Bifidobacterium Infantis Probiotic Capsule
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
Acne Scars, Ablative Fractional CO₂ Laser Therapy
Comparative Real-world Study on Ablative Fractional CO₂ Laser vs PRP With Microneedling for Acne Scar Treatment.
Road traffic accidents (RTAs) remain a major public health concern worldwide and in Bangladesh, contributing significantly to injury, disability, and premature death.
- Conditions
- Acne Scars, Ablative Fractional CO₂ Laser Therapy, Platelet-rich Plasma (PRP)
- Trial name
- NCT07189923
- Testing
- Ablative Fractional CO₂ Laser, Platelet-Rich Plasma (PRP) With Microneedling
- Where
- Bangladesh
- Volunteers
- 116 people
- Sponsor
- Dr. Sirajul Islam Medical College
Acne
An Observational Clinical Study to Evaluate the Efficacy of the CeraVe Skin Care Line
This is an observational clinical study to evaluate the efficacy of the CeraVe Skin Care product line in improving mild to severe facial acne.
- Trial name
- NCT07044024
- Testing
- CeraVe
- Volunteers
- 240 people
- Sponsor
- ChinaNorm
Acne Vulgaris
Efficacy and Safety of Clascoterone Cream 1% in Facial Acne Vulgaris
The primary objective of this study is to determine the safety and efficacy of clascoterone cream, 1%, versus the vehicle cream applied twice daily for 12 weeks in subjects with facial acne vulgaris.
- Trial name
- NCT06403501
- Testing
- Clascoterone, Vehicle cream
- Where
- China
- Volunteers
- 692 people
- Sponsor
- Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd.
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Comparison of the Clinical Efficacy and Safety of Topical and Subcutaneous Injection of Secukinumab in HS
Secukinumab is currently approved in Europe, US and China for the treatment of moderate to severe HS as a biologic agent targeting IL-17A.Two phase III clinical trials (SUNSHINE and SUNRISE) showed that 300 mg s.c.
- Conditions
- Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa), Secukinumab
- Trial name
- NCT07261072
- Testing
- Topical injection of Secukinmab, Subcutaneous injection of Secukinumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College
Acne Vulgaris
Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients
In Dermatology, assessment of people of color remains underrepresented in RCTs (<10%) and guidelines. Acne affects around 9% of the population worldwide and negatively affects quality of life and self-esteem with anxiety…
- Trial name
- ETHNIC (NCT06447480)
- Testing
- ISOtretinoin 5 MG, Topical cream
- Where
- 19 sites in France, French Guiana
- Volunteers
- 420 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acne
Exploring Acne Treatments Through Clinical Research Participation
The purpose of this study is to understand the lived experiences of acne patients enrolled in a related clinical trial testing a particular treatment.
- Trial name
- NCT07010458
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Acne Vulgaris
Serum CXCL10 and CRP Levels in Patients With Acne Vulgaris in Correlation With Disease Severity
the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity.
- Trial name
- CXCL10 (NCT06869109)
- Testing
- serum cxcl10, serum crp
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acne Vulgaris
Weekly Isotretinoin vs Tetracycline for Moderate Acne
In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options.
- Trial name
- NCT06225570
- Testing
- Isotretinoin, Tetracycline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Acne
Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients
This study aims to uncover the specific immunopathology, microbiome and pathophysiology of acne vulgaris in people living in a tropical climate such as Singapore.
- Trial name
- VBE00011 (NCT07411638)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Acne-prone Skin, Skin Disease
Observational Assessment of Skin Appearance Changes During PRX S Cosmetic Treatment in Participants With Acne-Prone Skin
This pilot cohort study evaluates changes in skin surface appearance in adult participants with acne-prone skin during and following a standardized five-session course of PRX S (WiQo SpA), a topical cosmetic product designed for…
- Trial name
- NCT07866131
- Testing
- PRX S topical cosmetic treatment, WiQo home care regimen (Nourishing Cream; Balancing Cream)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- WiQo S.p.A.
Post Inflammtory Erythema, Acne Vulgaris
Efficacy of 0.5% Topical Timolol Eye Drops in the Treatment of Post-Inflammatory Erythema Following Acne Vulgaris
Post-inflammatory erythema (PIE) is a common sequela of acne vulgaris, characterized by persistent erythematous macules resulting from superficial vascular dilation.
- Conditions
- Post Inflammtory Erythema, Acne Vulgaris, Erythema
- Trial name
- NCT07474883
- Testing
- Timolol 0.5% Ophthalmic Solution, Intense Pulsed Light
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Acne, Atopic Dermatitis
Sebum Metabolomics and Lipidomics for Clinical Applications
This study aims to develop a standardized workflow for sebum sampling and metabolomics/lipidomics analysis using Sebutape. A total of 200 participants will be recruited, including healthy individuals, patients with skin diseases…
- Conditions
- Acne, Atopic Dermatitis, Seborrheic Dermatitis, Psoriasis
- Trial name
- NCT07549828
- Testing
- Sebutape sampling, Bacitracin/Polymyxin B/Neomycin ointment (Yentuogin ointment)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acne Vulgaris
Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris
This study will compare the effectiveness and safety of topical clascoterone 1% cream and adapalene 0.1% cream in patients with mild-to-moderate acne vulgaris.
- Trial name
- NCT07883538
- Testing
- Clascoterone 1% cream, Adapalene 0.1% cream
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Pak Emirates Military Hospital
Acne
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Participants With Mild Acne
The purpose of the VBE00009 study is to evaluate the safety, efficacy and immunogenicity of 2 administrations of the Acne mRNA vaccine candidate at single dose level in participants aged 18 to 45 years with mild acne.
- Trial name
- NCT07013747
- Testing
- Acne mRNA vaccine
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Cutibacterium Acnes Contamination
Wound Irrigation Comparative Effectiveness Study
The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline…
- Trial name
- NCT06379919
- Testing
- Irrisept Irrigation, Saline Irrigation Solution Delivery
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Education and Research Institute (dba Hoag Orthopedics)