Clinical trials: bipolar
BIPOLAR DISORDER
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR
There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006).
- Trial name
- NCT00879307
- Testing
- quetiapine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hip Arthritis
Evaluation of the Efficacy of the Bipolar Sealer Aquamantys 6.0 in Patients Undergoing Total Hip Arthroplasty
The present prospective, single-center, clinical trial is designed to evaluate the hemostatic efficacy of the hemostatic sealer Aquamantys 6.0™ in patients managed with total hip arthroplasty (THA).
- Trial name
- Hip (NCT01027195)
- Testing
- Bipolar Radiofrequency (Aquamantys 6.0), Standard Bovie Electrocautery
- Volunteers
- 140 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation
Prophylactic Pulmonary Vein Isolation Study
This study is being done to learn the effects of the Pulmonary Vein Isolation in patients that are at high risk to developing, but do not have a documented history of atrial fibrillation.
- Trial name
- NCT00587899
- Testing
- Pulmonary Vein Isolation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Bipolar Disorder, Mania
Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder
This is an 8-week open-label study aimed at assessing the effectiveness and tolerability of Quetiapine, in the treatment of preschool children aged 4 to 6 years with bipolar and bipolar spectrum disorder.
- Trial name
- NCT00181883
- Testing
- quetiapine
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Bipolar, Mania, Bipolar, Mixed State
Prazosin as an Antimanic Agent in Severe Mania or Mixed States
Mania has been considered to be, in part, a hyperadrenergic state. One focus of treatment of mania involves directly targeting this hyperexcitable state by reducing arousal with antiadrenergic agents.
- Trial name
- NCT01621165
- Testing
- Addition of prazosin to usual care (add-on study)
- Sponsor
- Mclean Hospital
Depressive Disorder, Bipolar Disorder
Early Integrated Intervention in Severe Affective Disorders
The purpose of this study is to determine whether early integrated prophylactic combined medical and psychological outpatient treatment is associated with a better prognosis in patients with severe unipolar and bipolar affective…
- Trial name
- NCT00253071
- Testing
- Prophylactic combined medical and psychological treatment
- Where
- Denmark
- Volunteers
- 426 people
- Sponsor
- Hovedstadens Sygehusfaelesskab
Bipolar Disorder
Self-Monitoring and Psychoeducation in Bipolar Patients With a Smart-phone Application
Bipolar disorder is a frequent condition in the general population with a high morbimortality, which consists in dysfunctional temporal fluctuations between different mood phases ranging from depression to manic episodes with…
- Trial name
- SIMPLE (NCT02258711)
- Testing
- SIMPLE 2.0
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Hospital Clinic of Barcelona
Bipolar Disorder
Identification of Predictive Biomarkers of Mood Relapses in Patients With Bipolar Disorder
Relapses in bipolar disorders are associated with a significant proportional functional impact, as well as worsening of the course of bipolar disorder, with impairment of the quality of functional remission, as well as the…
- Trial name
- Predibip (NCT04703972)
- Testing
- clinical assessment (mood relapses identification)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Major Depressive Disorder, Bipolar Disorder
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
This prospective, open-label clinical trial aims to compare a novel "Venous Tourniquet with Regional Low-Dose Sugammadex" method against the gold standard "Arterial Tourniquet" (Isolated Forearm Technique - IFT) for monitoring…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT07534475
- Testing
- Device: Arterial Tourniquet, Device: Venous Tourniquet, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Bipolar Disorder
Aripiprazole in the Treatment of Bipolar Depression
A systematic open-label prospective pilot study to assess aripirazole for acute bipolar depression, with a secondary assessment of longer-term mood stabilization.
- Trial name
- NCT00226317
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Severe Mood Dysregulation
Pharmacological Treatment of Children and Adolescents With Severe Mood Dysregulation
The purpose of this study is to investigate whether Risperidone is effective in children and adolescents with severe mood dysregulation.
- Trial name
- NCT00825552
- Testing
- Risperidone
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Bipolar Disorder
Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders
This is a single center, open prospective study to evaluate the effectiveness of quetiapine monotherapy in the maintenance treatment of adolescent patients with a bipolar spectrum disorder (bipolar I and bipolar II disorders…
- Trial name
- NCT00252226
- Testing
- Quetiapine
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mood Disorders Center of Ottawa
Tonsillitis Chronic, Tonsillitis Recurrent
Adult Tonsillectomy Techniques: Blunt Dissection Vs Bipolar Radiofrequency
The aim of this study is to assess the effectiveness of bipolar radiofrequency techniques of tonsillectomy in adults.
- Trial name
- NCT07903233
- Testing
- Blunt Dissection, Bipolar Radiofrequency
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Schizophrenia, Bipolar Disorder
Emotional Eating, Sleep Quality, Mental State and Metabolic Syndrome
In predominantly medication-naïve schizophrenic patients, those exhibiting partial metabolic disorders have significantly worse sleep quality and sleep onset time; poor sleep predicted metabolic dysregulation even after…
- Conditions
- Schizophrenia, Bipolar Disorder, Psychiatric Issue, Metabolic Syndrome
- Trial name
- NCT07411222
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Abant Izzet Baysal University
Schizophrenia, Schizoaffective Disorder
The Effects of Aripiprazole on Patients With Metabolic Syndrome
The primary goal of this study is to assess the effect of aripiprazole on patients who developed metabolic syndrome while taking other second generation antipsychotic medications.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Metabolic Syndrome X
- Trial name
- NCT00224822
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- New Mexico VA Healthcare System
Bipolar Disorder
The STAGE Study for Bipolar Disorder
When the investigators are caught up in emotions, it is by stepping back (or decentering) that the investigators are able to see the situation from another perspective.
- Trial name
- NCT02597686
- Testing
- SD-PB training
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Bipolar Affective Disorders
Chemokine Receptors on CD8+ T Cells in Patients With Bipolar Disorder
This observational study investigates the expression profile of chemokine receptors and adhesion molecules in CD8+ T lymphocytes from individuals with Bipolar Disorder compared with healthy controls.
- Trial name
- SPERLIC (NCT07785167)
- Testing
- CD8+ T-Cell Gene Expression Analysis
- Where
- Italy
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Catania
Alcohol Dependence, Bipolar Disorder
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
The study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their…
- Conditions
- Alcohol Dependence, Bipolar Disorder, Depression, Mania
- Trial name
- NCT01015586
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
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