Clinical trials: bipolar
Senile Plaques, Tau Proteins
Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?
The purpose of this study is to identify association between cerebrospinal fluid Alzheimer's Disease's neurodegenerescence biomarkers (tau, ptau, Aß40 and Aß1-42) and occurrence of cognitive deficits in older patients with…
- Conditions
- Senile Plaques, Tau Proteins, Alzheimer Disease, Bipolar Disorders
- Trial name
- BIPAGE (NCT02843906)
- Testing
- Lombar Punction, Magnetic Resonance Imaging (MRI), Positron-Emission Tomography (TEP) /(FDG)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Grenoble
Bipolar Disorder, Unipolar Disorder
A Comprehensive Assessment and Follow up Descriptive Study on Bipolar Disorder
The purpose of this study was to investigate the reliability and validity of the bipolar index (BPX) to diagnosis bipolar disorder, and to verify the stability of it in identifying bipolar disorder; the secondary purpose was to…
- Trial name
- CAFE-BD (NCT02015143)
- Where
- China
- Volunteers
- 970 people, healthy volunteers welcome
- Sponsor
- Peking University
Radial Head Fractures
Comparison of Two Radial Head Implants
In severe injuries of the radial head with multiple, displaced fracture fragments and concomitant ligament damage, excision of the fragments and replacement of the radial head with a metallic implant are indicated.
- Trial name
- NCT01269840
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Northwestern University
Prostate Cancer
Focal Prostate Radio-Frequency Ablation
The main purpose of this study is to evaluate the safety and efficacy of focal (targeted) Radio-Frequency Ablation (RFA) in men with low or intermediate-risk, clinically localized prostate cancer.
- Trial name
- NCT02328807
- Testing
- Radio-Frequency Ablation (RFA)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Schizophrenia, Bipolar Disorder
Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder
This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness.
- Trial name
- NCT00382915
- Testing
- CReSSmicro handheld topography device
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Perioperative Outcomes
Comparison of Perioperative Outcomes of Three Different Instruments in Total Laparoscopic Hysterectomy
There are many instruments with different energy modalities or with different properties that are available for use in total laparoscopic hysterectomy.
- Trial name
- NCT01745315
- Testing
- Advanced bipolar devices
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Adana Numune Training and Research Hospital
Bipolar Disorder
Menstrual Effects On Mood Symptoms in Bipolar Disorder
Background and Rationale for Study: Estrogen and progesterone are female hormones that regulate the menstrual cycle and likely serve an important role in the regulation of mood.
- Trial name
- NCT00472615
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bipolar Disorder
Paliperidone Palmitate Efficacy and Safety in Bipolar Disorder Complicated by Alcoholism
The primary specific aim is to examine the efficacy of Paliperidone extended release Paliperidone Palmitate Injection (INVEGA® SUSTENNA™) compared to placebo in decreasing manic symptoms in patients with comorbid DSM-IV bipolar…
- Trial name
- NCT01211704
- Testing
- Paliperidone Palmitate
- Sponsor
- University of Miami
Bipolar Disorder, Depressive Disorder
Spot Depression Study
This study aims to identify signs of depression and bipolar disorder by measuring changes of certain molecules (biomarkers) that can be detected in dried blood spots.
- Trial name
- NCT02804867
- Testing
- Online questionnaire and self-administered blood spot
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Bipolar Disorder II, Major Depressive Disorder (MDD)
Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive Disorder
Bipolar Disorder Type II (BD-II) and Major Depressive Disorder (MDD) are common mood disorders associated with substantial psychological distress, impaired functioning, and reduced quality of life.
- Trial name
- NCT07679204
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Diabetes, Obesity
Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2
This program aims to help Veterans who take antipsychotic medications lose weight. We use a program based on the American Diabetes Association's "Diabetes Prevention Program," and we have modified it to fit the lifestyles of…
- Conditions
- Diabetes, Obesity, Weight Gain
- Trial name
- MAMAO2 (NCT01052714)
- Testing
- Lifestyle Balance
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- VA Office of Research and Development
Bipolar Disorder
A Study to Evaluate the Effect of Single Doses of Drug A (Lamotrigine) and Drug B (Vofopitant) Alone and in Combination on Resting Motor Threshold in Healthy Subjects
The purpose of this study is to investigate the effect of drug A on its own and when it is given in combination with drug B on markers of brain activity. The study will 1.
- Trial name
- NCT00907985
- Testing
- Vofopitant, Lamotrigine
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bipolar Depression
An Open Label Trial of TMS Therapy for Bipolar Depression
Transcranial Magnetic Stimulation (TMS) is an increasingly accepted neurostimulation- based treatment for major depressive disorder.
- Trial name
- NCT02640950
- Testing
- NeuroStar TMS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sheppard Pratt Health System
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime and is associated with worse illness outcomes, yet few studies have been performed to clarify the causes of this…
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- Long_BACS (NCT05838274)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Bipolar Disorder, Mood Disorders
A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder
The purpose of this study is to evaluate the effectiveness and safety of flexible-doses paliperidone ER (3 to 12 mg as needed) compared with placebo over 3 weeks in patients with Bipolar I Disorder who are experiencing an acute…
- Trial name
- NCT00309699
- Testing
- Quetiapine, Paliperidone ER
- Where
- 47 sites in United States, Greece and 6 more
- Volunteers
- 493 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorder
Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder
The clinical use of clozapine has been an unequivocal advance in the treatment of schizophrenia, a chronic and severe mental illness.
- Trial name
- NCT02562287
- Testing
- Clozapine, Risperidone, Olanzapine
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Bipolar I Disorder, Depression
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
This is a sequential multiple assignment randomized trial for adults (ages > 18) with a bipolar disorder type 1 and type 2 diagnosis currently experiencing a depressive episode.
- Trial name
- SMART-BD (NCT06433635)
- Testing
- Cariprazine, Aripiprazole/Escitalopram combination, Quetiapine
- Where
- 18 sites in United States, Canada
- Volunteers
- 2,726 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Manic, Artificial Intelligence
Correlation of Audiovisual Features With Clinical Variables and Neurocognitive Functions in Bipolar Disorder, Mania
The aim of this study is to show the physiological changes during manic episode in bipolar mania how much they differentiate from remission and healthy control.
- Conditions
- Bipolar Disorder, Manic, Artificial Intelligence, Neurocognition, Treatment Resistant Disorders
- Trial name
- NCT03857438
- Testing
- Ongoing treatment for bipolar mania, Audiovisual recording during guided presentation
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Schizophrenia, Bipolar Disorder
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Many individuals with serious mental illness have difficulty accurately interpreting interpersonal cues and effectively engaging in social exchanges.
- Conditions
- Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Stress Disorder, Post-Traumatic
- Trial name
- NCT05491538
- Testing
- Social Cognition and Interaction Training-Work Edition (SCIT-WE)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Hip Arthritis
Evaluation of the Efficacy of the Bipolar Sealer Aquamantys 6.0 in Patients Undergoing Total Hip Arthroplasty
The present prospective, single-center, clinical trial is designed to evaluate the hemostatic efficacy of the hemostatic sealer Aquamantys 6.0™ in patients managed with total hip arthroplasty (THA).
- Trial name
- Hip (NCT01027195)
- Testing
- Bipolar Radiofrequency (Aquamantys 6.0), Standard Bovie Electrocautery
- Volunteers
- 140 people
- Sponsor
- The Cleveland Clinic
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