Clinical trials: bipolar
Bipolar Disorder
Pharmacokinetics of Quetiapine Across Pregnancy and Postpartum
The widespread and common use of quetiapine in childbearing and pregnant women demands more data to inform dosing and toxicity in pregnancy.
- Trial name
- Quetiapine (NCT02978534)
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Schizophrenia, Bipolar Disorder
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders
This is a single center study that uses both between-group comparisons and correlational analyses to establish biomarkers of dysmyelination and cognitive impairment in Psychotic Spectrum Disorders using imaging and…
- Trial name
- NCT03166098
- Testing
- Cognitive Function Assessments
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- NYU Langone Health
Resistant Major Depression
Pentoxifylline for Treatment of Resistant Major Depression
A growing body of evidence has highlighted the role of inflammation and phosphodiesterases (PDE)-related pathways in the pathogenesis of neuropsychiatric illnesses such as depression/mood disorders.
- Trial name
- NCT05324735
- Testing
- Pentoxifylline
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Hawler Medical University
Major Depressive Disorder, Bipolar Disorder
Multi-factor Model Constraction for Early Warning and Diagnosis of MDD
Current research on the pathogenesis of depression shows that imbalanced inflammatory factors are closely related to Major Depressive Disorder(MDD).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Omega-3 Fatty Acids
- Trial name
- NCT05529576
- Testing
- Omega 3 fatty acid
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder, Bipolar Disorder
Transdiagnostic Markers of Cognitive Symptoms in Disorders Affective.
The objective of this project is to determine the concordance between the subjective and objective evaluation of cognitive functions in affective patients in partial remission through scales and cognitive tests that would be…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, BDMF, GSH
- Trial name
- NCT05523076
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Bipolar Disorder, Type 1
Evaluation of Theta-burst Stimulation Efficacy, Safety and Tolerability in Major Depressive Episodes of Bipolar I Disorder
INTRODUCTION: Pharmacological treatment of major depressive episodes in bipolar disorder (BD) is characterized by suboptimal efficacy rates, poor tolerability and adherence, delayed onset of action, and iatrogenic mood swings.
- Trial name
- NCT05501626
- Testing
- Active Theta Burst Stimulation (TBS)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Dialectical Behavior Therapy + Pharmacotherapy, Standard of Care Psychotherapy + Pharmacotherapy
Dialectical Behavior Therapy (DBT) for Adolescents With Bipolar Disorder
Of all psychiatric diagnoses, bipolar disorder imparts the greatest risk for completed suicide in adolescence, and is further associated with poor psychosocial functioning, substance abuse and legal difficulties, and exorbitant…
- Trial name
- DBT (NCT02003690)
- Testing
- Dialectical Behavior Therapy, Standard of Care Psychotherapy, Pharmacotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Bipolar Depression, Suicidal Ideation
NRX101 Glx Biomarker Validation Study
Subnormal level of Glutamate+Glutamine (Glx) in the Anterior Cingulate Cortex (ACC) of the brain has been associated with depression and PTSD.
- Trial name
- NRX-GLX (NCT03402152)
- Testing
- NRX-101, Lurasidone HCl
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- NeuroRx, Inc.
Bipolar Disorder
Interval Training in Bipolar Disorder
Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as…
- Trial name
- HIIT (NCT02498730)
- Testing
- Interval Training, Continuous Training, Control
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Bipolar Disorder, Bipolar Depression
PET and MRI Brain Imaging of Bipolar Disorder
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2.
- Conditions
- Bipolar Disorder, Bipolar Depression, Unipolar Depression
- Trial name
- NCT01880957
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Major Depressive Disorder, Bipolar Depression
Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy
The PWECT015 study was designed to compare the application of 0.15ms and 0.30ms pulse width in electroconvulsive therapy (ECT). Subjects will be compared both within groups and in-group via psychometric scales.
- Trial name
- PWECT015 (NCT05465915)
- Testing
- Electroconvulsive therapy
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Bipolar I Disorder
Optimizing Response to Li Treatment Through Personalized Evaluation of Individuals With Bipolar I Disorder: The R-LiNK Initiative
Bipolar disorder (BD), especially BD type I, is a highly prevalent mental disorder and a is a highly prevalent mental disorder and an important factor for suicide.
- Trial name
- R-LiNK (NCT04209140)
- Testing
- lithium treatment
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Motivational Interviews, Bipolar Disorder
Motivational Interviewing in Patients With Bipolar Disorder
Introduction: A poor therapeutic relationship, poor quality of life, impaired functioning, ineffective coping methods, and lack of motivation It is associated with poor adjustment (to symptoms, treatment, and environment) in…
- Trial name
- NCT05428241
- Testing
- Assigned Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Pamukkale University
Bipolar Disorder, Bipolar I Disorder
The Effect of Interpersonal Relationships and Social Rhythm Therapy Individuals With Bipolar Disorder
Interpersonal and Social Rhythm Therapy (IPSRT) is a type of psychotherapy that applies social rhythm theories in bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- IPSRT (NCT05420792)
- Testing
- Peplau Interpersonal Relations based IPSRT will be applied to the intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ege University
Schizophrenia, Psychotic Disorders
Role Functioning Changes NOS
During this study the investigators will 1) collect measures of social cognition and social functioning in adolescents and young adults who are experiencing early symptoms of a major mental disorder; and 2) evaluate the…
- Conditions
- Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- NCT02505022
- Testing
- Pharmacotherapy, Behavioral treatment
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Northwestern University
Bipolar Depression
Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally
The study will evaluate the efficacy and safety of ITI-007 in a randomized, double-blind, parallel-group, placebo-controlled, multi-center study in patients diagnosed with Bipolar I or Bipolar II disorder having a major…
- Trial name
- NCT03249376
- Testing
- Lumateperone
- Where
- 47 sites in United States, Bulgaria and 4 more
- Volunteers
- 381 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Bipolar Depression
An Open Label Trial of TMS Therapy for Bipolar Depression
Transcranial Magnetic Stimulation (TMS) is an increasingly accepted neurostimulation- based treatment for major depressive disorder.
- Trial name
- NCT02640950
- Testing
- NeuroStar TMS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sheppard Pratt Health System
Bipolar Disorder, Personality Disorders
The Role of Group Identity on the Community Integration of People With Severe Mental Disorder
This study analyzes which variables enhance or hinder community integration among people with severe mental disorder. Participants will complete a questionnaire to test our hypotheses: Hypothesis 1: group identification predicts…
- Conditions
- Bipolar Disorder, Personality Disorders, Psychotic Disorders
- Trial name
- NCT04304417
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Universidad Complutense de Madrid
Bipolar Disorder
Cognitive-Behavioral Rehabilitation for Bipolar Disorder
The study consists of a clinical trial comparing a new structured group intervention, denominated "Cognitive-Behavioral Rehabilitation", to treatment as usual (TAU) for bipolar patients.
- Trial name
- REHABBipolar (NCT02766361)
- Testing
- Cognitive Behavioral Rehabilitation, Treatment as Usual
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo