Clinical trials: bipolar
Major Depressive Disorder, Bipolar I and Bipolar II
Microbiome of Depression & Treatment Response to Citalopram
The purpose of this study is to evaluate the feasibility of developing a microbiome probe of depression and to evaluate the microbiome change in a preliminary analysis of treatment response (n=20) vs.
- Trial name
- NCT02330068
- Testing
- citalopram
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bipolar Disorder
A Study to Evaluate the Efficacy of FK949E in Bipolar Disorder Patients With Major Depressive Episodes
In period I, the treatment effect of FK949E was compared with that of placebo in a blind manner in bipolar disorder patients with major depressive episodes. In period II, the long-term safety and efficacy of FK949E was evaluated.
- Trial name
- NCT01725308
- Testing
- FK949E
- Where
- 98 sites in Japan
- Volunteers
- 431 people
- Sponsor
- Astellas Pharma Inc
Premenstrual Dysphoric Disorder, Bipolar Disorder
Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder
This study is a pilot, randomized, placebo-controlled trial evaluating the treatment of Premenstrual Dysphoric Disorder comorbid with Bipolar Disorder using combined oral contraceptives.
- Trial name
- NCT05098574
- Testing
- Yaz
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Osteoarthritis, Hip, Blood Loss
Bipolar Sealer for Reduction of Blood Loss in Anterior Total Hip Arthroplasties
The overall objectives and purpose of this study is to show that the Smith and Nephew Werewolf Fastseal 6.0 Bipolar Sealer is an effective tool to aide the surgical team in providing significant hemostasis during anterior total…
- Trial name
- NCT05356637
- Testing
- Werewolf Fastseal 6.0
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- North Texas Medical Research Institute, PLLC
Alcoholism, Bipolar Disorder
Drug Treatment for Alcoholics With Bipolar Disorder
The purpose of this study is to test the effectiveness of sodium valproate (Depacon) in treating individuals with alcohol dependence and comorbid bipolar disorder.
- Trial name
- NCT00000439
- Testing
- sodium valproate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Schizophrenia, Schizoaffective Disorder
Outcome Evaluation of Solutions for Wellness and Team Solutions Program in Patients With Severe Mental Illness
Obesity is increasing at an alarming rate in patients with schizophrenia, possibly in association with the increased use of atypical antipsychotics.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- Wellness (NCT00661869)
- Testing
- Wellness Program
- Where
- United States
- Volunteers
- 295 people
- Sponsor
- Manhattan Psychiatric Center
Schizophrenia, Schizoaffective Disorder
Improving Diabetes Risk Factors in Persons With Schizophrenia or Bipolar Disorder by Switching to Ziprasidone
Having a diagnosis of schizophrenia or bipolar disorder and being treated with certain of the newer antipsychotics are risk factors for development of diabetes.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00538642
- Testing
- ziprasidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pregnancy, Bipolar Disorder
Bipolar Disorder (BPD) in Pregnancy: Predictors of Morbidity
Very little is known about the impact of pregnancy and the postpartum period on BPD. As a result, the investigators have little evidence on which to base treatment guidelines.
- Trial name
- NCT00864370
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- Emory University
Sleep Problem, Bipolar Disorder
Better Sleep in Psychiatric Care - Bipolar
Cognitive Behavioral Therapy (CBT) is treatment of choice for insomnia. Many patients in psychiatric care have sleep problems including insomnia, but are rarely given the choice to participate in CBT to improve their sleep.
- Trial name
- BSIP-Bipolar (NCT04130529)
- Testing
- Adjusted group CBT-i for Bipolar disorder, Sleep lectures
- Where
- 2 sites in Sweden
- Volunteers
- 87 people
- Sponsor
- Karolinska Institutet
Nicotine Dependence
Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder
Bipolar Disorder is a chronic relapsing mental disorder characterized by periods of elevated, expansive and irritable mood, often alternating with periods of significant clinical depression.
- Trial name
- NCT01093937
- Testing
- varenicline
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
Neurofeedback for Bipolar Disorder
Bipolar Disorder (BD) is a severe mood disorder affecting between 1% and 3% of the general population. It is characterized by the succession of depressive and manic episodes, with periods of stabilization during which patients…
- Trial name
- NEUROFEED-BD (NCT05802446)
- Testing
- Real-time fMRI Neurofeedback
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Disorder
Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
The aim of the study was to determine the pharmacological induced equivalents of neurogenesis and synaptic sprouting in the hippocampus, localized volume changes, changes in water content and neurochemical changes in the medial…
- Trial name
- NCT01552837
- Testing
- Seroquel
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Bipolar Disorder, Coping Skills
Acceptance and Commitment Therapy Based Psychoeducation, Meaning of Life and Coping Skills in Bipolar Disorder
This research will be conducted to determine the effect of acceptance and commitment therapy-based psychoeducation on coping skills and finding meaning in life in patients with bipolar disorder.
- Trial name
- NCT06131866
- Testing
- Psychoeducation based on Acceptance and Commitment Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kubra TOHUMCU
Schizophrenia, Schizophreniform Disorder
Electronic Cigarettes in Smokers With Mental Illness
People with mental illness are more likely to smoke and are more severely addicted to nicotine than the general population. As a result, the number of deaths related to tobacco is higher.
- Conditions
- Schizophrenia, Schizophreniform Disorder, Bipolar Disorder
- Trial name
- APUS e-Cigs (NCT02212041)
- Testing
- disposable electronic cigarettes
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Depression, Bipolar
Safety, Tolerability, and Efficacy of Cariprazine in Participants With Bipolar Depression
The objective of this study was to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of participants with bipolar depression.
- Trial name
- NCT01396447
- Testing
- Cariprazine
- Where
- 88 sites in United States, Bulgaria and 4 more
- Volunteers
- 584 people
- Sponsor
- Forest Laboratories
Bipolar Disorder
Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder
This study evaluated whether lithium included as part of optimized medication treatment improved overall level of illness, symptoms of mania and depression, and quality of life in people with bipolar disorder.
- Trial name
- LiTMUS (NCT00667745)
- Testing
- Lithium Carbonate, Optimized Treatment (OPT)
- Where
- 6 sites in United States
- Volunteers
- 283 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Cognitive Impairment
Cognitive Stimulation for Elderly Bipolar Patients
Age is a major risk factor for the development of cognitive disorders and neurodegenerative pathologies. Cognitive disorders during the phases of bipolar disease are known to exist, and alterations increase significantly after…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Age-related Cognitive Decline
- Trial name
- TONIC (NCT04184375)
- Testing
- cognitive stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Bipolar Disorder
A Study Evaluating the Efficacy of Administered Maintenance Treatments in Bipolar Disorder I and II.
The primary objective of the study is to evaluate the efficacy of administered maintenance treatments in bipolar disorder I and II, defined as the percentage of patients who experience a relapse episode during the first 9 months…
- Trial name
- NCT01202604
- Where
- 33 sites in Greece
- Volunteers
- 294 people
- Sponsor
- AstraZeneca
Bipolar Disorder
DB/Maintenance of Equetro (Carbamazepine) in Children With Acute Manic or Mixed Bipolar 1 Disorder
A phase 4 unequal randomization, double blind study to evaluate the dose tolerance and safety of extended release Equetro (carbamazepine) versus placebo followed by an Open label and long term maintenance treatment in children…
- Trial name
- NCT02623504
- Testing
- Carbamazepine
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Validus Pharmaceuticals
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