Clinical trials: bipolar
Bipolar Depression
Lamotrigine Therapy in Geriatric Bipolar Depression
We propose to study the efficacy and tolerability of lamotrigine in the treatment of older adults with bipolar depression and to compare measures of brain energy metabolism between older subjects with bipolar depression and…
- Trial name
- NCT00720473
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder, Anxiety
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
The primary objective is to test the hypothesis that Quetiapine XR (Extended Release) monotherapy and adjunctive therapy is effective in the acute treatment of bipolar depression and comorbid generalized anxiety disorder in…
- Conditions
- Bipolar Disorder, Anxiety, Anxiety Disorders, Substance Use Disorders
- Trial name
- NCT00671853
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University Hospitals Cleveland Medical Center
Schizophrenia, Schizoaffective Disorder
Comparing Thinking Skills for Work (TSW)Home Practice Program With Traditional TSW Program
The purpose of this study is to determine if using a tablet computer, which is a very small, easy-to-carry computer, to practice thinking exercises at home will help improve your attention, memory, and problem solving abilities.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT03005574
- Testing
- TSW-HP, TSW-T
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston University Charles River Campus
Severe Mental Disorder, Schizophrenia
Prediction and Intervention Effect of Rehabilitation Status for Severe Mental Disorder Patients Based on Multimodal Analysis and AI Agents
Mental health issues represent a major public health and social problem that significantly impacts economic and social development.
- Conditions
- Severe Mental Disorder, Schizophrenia, Schizoaffective Disorder, Paranoid Psychosis
- Trial name
- NCT06904079
- Testing
- Gamified Digital Rehabilitation, Routine Care
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai Mental Health Center
Bipolar, Mania, Utapine
Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania
The goal of this research is to evaluate the safety as well as effectiveness of Utapine and Seroquel in bipolar I disorder patients.
- Conditions
- Bipolar, Mania, Utapine, Seroquel
- Trial name
- UtapMani (NCT01043679)
- Testing
- Utapine, Seroquel
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Schizophrenia, Schizoaffective
Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness
This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective, Bipolar Disorder 1
- Trial name
- ESHANTI (NCT05157620)
- Testing
- Yoga-based Exercise (YE), Wellness Lifestyle Program (WLP)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Perioperative Period
The Comparison of Conventional and Advanced Bipolar Energy Modalities During Laparoscopic Staging Surgery of Gynecologic Cancers
This single-institution prospective randomized clinical trial will be performed at the Gynecologic Oncology clinic of Ankara University.
- Trial name
- NCT02822820
- Testing
- Ligasure-Covidien, RoBi forceps-Karl Storz
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara University
Bipolar Disorder
Culturally Adapted Psychoeducation for Bipolar Disorder in a Low-resource Setting: A Randomized Controlled Trial
Study objectives: 1. To determine the effectiveness of the CaPE intervention compared to treatment as usual (TAU) in reducing the time to recurrence for people with bipolar disorder (BD) I/II, currently in remission in Pakistan…
- Trial name
- CaPE (NCT05223959)
- Testing
- Culturally adapted Psychoeducation
- Where
- Pakistan
- Volunteers
- 303 people
- Sponsor
- Pakistan Institute of Living and Learning
Schizophrenia, Schizoaffective Disorder
Observational Study to Evaluate Bipolar Disorder Symptoms in Patients Presented With Schizophrenia or Depression
This study is aimed to evaluate the bipolar disorder symptoms in patients presented with schizophrenia, schizoaffective disorder or recurrent depression.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Recurrent Depression
- Trial name
- NCT01028196
- Where
- 3 sites in Russia
- Volunteers
- 750 people
- Sponsor
- AstraZeneca
Bipolar Disorder, Transcranial Magnetic Stimulation
Pilot Study of Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders
The investigators are conducting this research study to better understand how individuals with bipolar disorder regulate their emotions, and if the study can use a technique called "transcranial magnetic stimulation" or TMS to…
- Trial name
- NCT03622749
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Depression, Bipolar
Adjunctive Ziprasidone in the Treatment of Bipolar I Depression
The purpose of this study is to determine if a treatment regimen of ziprasidone plus a mood stabilizer is safe and effective in the short term treatment of Bipolar I Depression.
- Trial name
- NCT00483548
- Testing
- Ziprasidone
- Where
- 70 sites in United States, Australia and 1 more
- Volunteers
- 298 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bipolar I Disorder, Psychosis
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar…
- Conditions
- Bipolar I Disorder, Psychosis, Schizoaffective Disorder
- Trial name
- NCT06221852
- Testing
- Ketogenic diet, Dietary Guidelines for Americans
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Severe Mental Disorders, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Severe Mental Disorders, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03837340)
- Testing
- CMHT, CAU
- Where
- Montenegro
- Volunteers
- 160 people
- Sponsor
- Special Psychiatric Hospital Kotor
Endometrial Polyp
Hysteroscopic Tissue Removal System Versus Bipolar Resectoscopy for Polypectomy: Long-term Results
In this study, a comparison is made between two types of polyp resection methods (hysteroscopic tissue removal and bipolar resectoscopy).
- Trial name
- NCT05337046
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- University Hospital, Ghent
High-risk, Bipolar Disorder
A Cohort Study of Disease Prediction Model for High-risk Population With Bipolar Disorder
Bipolar disorder (BD) is a serious, complicated, familial aggregation onset of mental illness, which has the characteristics of five-low and one-high, namely high prevalence, high recurrence rate, high morbidity and mortality…
- Conditions
- High-risk, Bipolar Disorder, Atypical Depression
- Trial name
- DPM-rBD (NCT07031661)
- Testing
- This was an observational study with no intervention.
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Gonarthrosis
Bipolar RFA Versus Phenol Neurolysis for Knee Osteoarthritis Pain
This prospective observational comparative study evaluates the analgesic efficacy and safety of ultrasound-guided bipolar radiofrequency ablation (BPRFA) versus phenol chemical neurolysis (PCN) of the genicular nerves in patients…
- Trial name
- NCT07805161
- Testing
- Phenol Chemical Neurolysis, Ultrasound-Guided Bipolar Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Saglik Bilimleri Universitesi
Bipolar Disorder
Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder
This is a research study comparing the safety and efficacy of two active study medications for the treatment of bipolar I disorder.
- Trial name
- NCT00034580
- Testing
- olanzapine, risperidone
- Where
- 21 sites in United States
- Volunteers
- 326 people
- Sponsor
- Eli Lilly and Company
Schizophrenia, Major Depressive Disorder
Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, or Bipolar Disorder Attending a Psychiatric Day Hospital in Taiwan
Schizophrenia is characterized by positive symptoms such as delusions and hallucinations, which significantly impact daily functioning.
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT07051746
- Testing
- Metacognitive Training (MCT), Traditional Chinese version
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- ZI-YU LIN
Bipolar Disorder, Depression
Positive Psychology for Mood Disorders
The investigators are doing this study to see if "positive psychology" can help adults with depression or bipolar disorder. Positive psychology involves exercises-short tasks-that try to increase good feelings and emotions, like…
- Trial name
- PPBPAD (NCT01820286)
- Testing
- Positive psychology intervention, Recollection intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
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