Clinical trials: bipolar
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Disorder
Functional and Neurochemical Brain Changes in First-episode Bipolar Mania
The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium.
- Trial name
- NCT00609193
- Testing
- lithium, quetiapine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Cincinnati
Adolescent Schizophrenia, Child or Adolescent Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features
Safety and Tolerability of Aripiprazole in Adolescents With Schizophrenia or Children and Adolescents With Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features.
This is an open-label study consisting of a screening period, a conversion/titration phase (Phase 1), an open-label treatment phase (Phase 2), and a follow-up period.
- Trial name
- ATTAIN 267 (NCT01122927)
- Testing
- Aripiprazole
- Where
- 101 sites in United States, Bulgaria and 11 more
- Volunteers
- 524 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Disorder
Time-Restricted Eating and Bipolar Disorder
This is a pilot trial to examine the acceptability and feasibility of time-restricted eating as an adjunct to medication treatment for bipolar disorder.
- Trial name
- NCT06105294
- Testing
- time-restricted eating
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Berkeley
Unipolar Depression, Bipolar Depression
Berlin Magnetic Seizure Therapy Depression Trial 01
This treatment pilot study will investigate clinical efficacy and adverse effects of magnetic seizure therapy (MST) in patients currently experiencing a unipolar or bipolar depressive episode.
- Trial name
- NCT00914680
- Testing
- magnetic seizure therapy
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Charite University, Berlin, Germany
Bipolar Disorder
Targeting the Microbiome to Improve Clinical Outcomes in Bipolar Disorder
The objective of this study is to determine how specific dietary control alters the microbiome composition to effect clinical outcome measures in a longitudinal study of individuals with bipolar disorder.
- Trial name
- NCT02855762
- Testing
- High polyunsaturated fatty acid diet.
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Melvin McInnis, MD
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Prostate Cancer
Extreme Bipolar Androgen Therapy With Darolutamide and Testosterone Cypionate in Patients With Metastatic Castration-Resistant Prostate Cancer (ExBAT Trial)
This is a multi-center, open-label, phase II, single-arm trial evaluating combination of darolutamide and high testosterone doses - extreme bipolar androgen therapy (ExBAT) - in patients with metastatic castration-resistant…
- Trial name
- ExBAT (NCT04558866)
- Testing
- Testosterone Cypionate, Darolutamide
- Where
- 6 sites in Brazil
- Volunteers
- 51 people
- Sponsor
- Latin American Cooperative Oncology Group
Bipolar Disorder, Schizo Affective Disorder
Brain Stimulation and Cognitive Training
People with serious mental illness often report difficulties with thinking skills like memory. These difficulties can make it harder to perform day-to-day activities.
- Conditions
- Bipolar Disorder, Schizo Affective Disorder, Schizophrenia
- Trial name
- NCT03338673
- Testing
- tDCS, BrainHQ
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Bipolar Disorder, Depressive Disorder
Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression
This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway.
- Trial name
- NCT00001483
- Testing
- buproprion (Wellbutrin), sertraline (Zoloft), venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder
Culturally Adapted Psychological Intervention for Bipolar Disorder in Pakistan
Aim: To assess the Feasibility RCT of the efficacy of a culturally adapted psychological intervention for Bipolar disorder in Pakistan Design: Randomized Control Trial Setting: Psychiatric Departments of different Hospitals in…
- Trial name
- NCT02210390
- Testing
- Psycho education
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Pakistan Institute of Living and Learning
Bipolar Disorder
Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders
The primary aim of this proposal is to conduct a preliminary controlled trial of valproate and risperidone in children ages 3-7 yr. with bipolar disorders.
- Trial name
- NCT00221403
- Testing
- Risperidone oral solution, Valproate Oral Solution
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bipolar Disorder
Cognitive-Behavioral Rehabilitation for Bipolar Disorder
The study consists of a clinical trial comparing a new structured group intervention, denominated "Cognitive-Behavioral Rehabilitation", to treatment as usual (TAU) for bipolar patients.
- Trial name
- REHABBipolar (NCT02766361)
- Testing
- Cognitive Behavioral Rehabilitation, Treatment as Usual
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Bipolar Disorder (BD), Internalized Stigma
The Effect of Cognitive Behavioral Psychoeducation on Internalized Stigma in Individuals With Bipolar Disorder
Since ancient times, societies have exhibited negative, discriminatory, labeling, and stigmatizing attitudes toward mental disorders and individuals with psychiatric conditions.
- Conditions
- Bipolar Disorder (BD), Internalized Stigma, Psychoeducation
- Trial name
- education (NCT07733297)
- Testing
- Cognitive-behavioral based psychoeducation program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Eskisehir Osmangazi University
Bipolar Depression
Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness
This is a randomized placebo-controlled trial to examine the efficacy of six-week bright light therapy as adjunctive treatment for patient with bipolar depression and eveningness.
- Trial name
- NCT05357313
- Testing
- Bright light therapy, Inactive negative ion generator
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Bipolar Disorder
Functional Remediation for Bipolar Disorder
Bipolar Disorder is a major mood disorder with periodic mood episodes that may be very distressing, both to the individual and to others.
- Trial name
- NCT03403179
- Testing
- Functional Remediation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Bipolar I Disorder
An Observational Modified Prescription-event Monitoring Study of Asenapine (Sycrest)
This post-marketing Modified Prescription-Event Monitoring (M-PEM) safety study of asenapine (SYCREST®) is to be carried out by the Drug Safety Research Unit (DSRU) as part of the Risk Management Plan required by the Committee…
- Trial name
- NCT01765127
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- Professor Saad Shakir
Metabolic Syndrome, Bipolar Depression
Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance
The study is an open-label 8-week adjunctive trial of pioglitazone for the acute relief of bipolar depression comorbid with metabolic syndrome/insulin resistance.
- Conditions
- Metabolic Syndrome, Bipolar Depression, Insulin Resistance
- Trial name
- NCT00835120
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Bipolar Disorder
Safety Study of Sodium Divalproate in Bipolar Disorder in Adolescents
Main objective: To evaluate the clinical and physiological tolerance of sodium divalproate in manic, mixed or hypomanic episodes of bipolar disorder in adolescents treated for 6 months.
- Trial name
- ADOKOT (NCT00271258)
- Testing
- SODIUM DIVALPROATE
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Sanofi
Femoral Neck Fractures
Project JAY HAP Registration Study
This is a prospective, randomized, multicenter clinical study in elderly Chinese subjects to compare the safety and efficacy of the SS Bipolar Head and SL-TWIN Stem with Bipolar Head and SL-PLUS Stem in hemiarthroplasty of the hip
- Trial name
- NCT02347397
- Testing
- SS Bipolar Head + SL-TWIN Stem, Bipolar Head + SL-PLUS Stem
- Where
- 5 sites in China
- Volunteers
- 134 people
- Sponsor
- Smith & Nephew Orthopaedics (Beijing) Limited
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