Clinical trials: bipolar
Bipolar Disorder, Major Depressive Disorder
Sleep Quality, Cognitive Performance, and Computerized Cognitive Training
Poor sleep quality is common in neuropsychiatric conditions and some of the problems associated with poor sleep at night may be due to medication side effects or reduced efficacy of certain treatments.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Psychosis
- Trial name
- NCT06328140
- Testing
- Lurasidone, FDA Approved antidepressant treatment
- Where
- United States
- Sponsor
- George West Mental Health Foundation d/b/a Skyland Trail
Major Depressive Disorder, Bipolar Disorder
Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders
Tobacco smoking is significantly more common among individuals with mood disorders, such as major depressive disorder (MDD) and bipolar disorder, compared to the general population.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Tobacco Use Disorder, Mood Disorders
- Trial name
- NCT07910318
- Volunteers
- 240 people
- Sponsor
- Assiut University
Bipolar Disorder
Study of Aripiprazole in Patients With a History of Bipolar Disorder
The purpose of this study is to learn if aripiprazole is effective in the treatment of patients with a history of bipolar disorder.
- Trial name
- NCT00036348
- Testing
- Aripiprazole
- Where
- 19 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Delivery
Cortisol Levels in Infants Born by C-section - Electric Unipolar Needle Versus Electric Bipolar Needle
The purpose of this study is to determine whether there is a difference between cortisol levels in fetal blood of babies who were born while using a unipolar needle opposite to using a bipolar needle, and compared to the control…
- Trial name
- NCT01100970
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bipolar Disorder
Oral Uridine for Treatment of Bipolar Depression in Adolescents
The purpose of the study is to see if the investigational medication uridine reduces depression symptoms in adolescents with bipolar disorder. Uridine is a naturally occurring chemical that is made by the human liver.
- Trial name
- NCT00841269
- Testing
- Uridine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Utah
Schizophrenia, Bipolar Disorder
Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders
The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering simple visual stimuli and/or personal…
- Trial name
- Self and Time (NCT02765880)
- Testing
- fMRI, EEG
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Resistant Depression, Treatment, Bipolar Depression
Efficacy and Biomarkers of Response of TBS in Treatment Resistant Depression
Theta Burst Transcranial Magnetic Stimulation (TBS) in dorsolateral prefrontal cortex (DLPFC) has shown efficacy and safety as an adjuvant strategy for resistant to treatment depression (RTD) in daily sessions during 4-6 weeks…
- Trial name
- EMTtfNI (NCT04998773)
- Testing
- Theta Burst Transcranial Magnetic Bilateral Stimulation, Theta Burst Transcranial Magnetic Unilateral Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Bipolar Disorder Mania
Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder
The purpose of the study is to determine whether aripiprazole provides additional clinical benefit to patients with Bipolar I disorder when combined with lithium or valproate over 12 weeks.
- Trial name
- NCT00665366
- Testing
- Aripiprazole, Lithium, Valproate
- Where
- 73 sites in Austria, Czechia and 11 more
- Volunteers
- 493 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Schizophrenia, Schizoaffective Disorder
Estimating and Reducing the Cardiovascular Risk of Patients With Schizophrenia Drugs From Lipid Measures and Ischemic Electrocardiographic Changes
The primary goal of this study is to examine the triglyceride/high-density lipoprotein (TG/HDL) ratio and the ischemic EKG changes in patients with schizophrenia, schizoaffective disorder or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00288353
- Testing
- aripiprazole (Abilify), ziprasidone (Geodon)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Northwestern University
Schizophrenia, Schizo-Affective Disorder
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
This is a study of the efficacy and safety of BXCL501 in children and adolescents with acute agitation and either bipolar disorder or schizophrenia.
- Conditions
- Schizophrenia, Schizo-Affective Disorder, Schizophreniform; Schizophrenic, Bipolar Disorder I
- Trial name
- NCT05025605
- Testing
- BXCL501 80 Micrograms, BXCL501 120 Micrograms, BXCL501 60 Micrograms
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- BioXcel Therapeutics Inc
Bipolar Disorder
Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania
Background: Bipolar disorder is one of the most common mental illnesses affecting 1%-4% of the population, and one of the leading causes of worldwide disability.
- Trial name
- NCT01893229
- Testing
- Lithium, Valproate, Oxcarbazepine
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Guiyun Xu
Cryoneurolysis, Bipolar Radiofrequency Ablation
Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis
This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.
- Conditions
- Cryoneurolysis, Bipolar Radiofrequency Ablation, Genicular Nerves, Pain Relief
- Trial name
- NCT07855367
- Testing
- Ultrasound-guided cryoneurolysis, Bipolar radiofrequency ablation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute, Egypt
Depression, Bipolar Disorder
Prevention of Mood Disorders by Folic Acid Supplementation
The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or…
- Trial name
- PRE-EMPT (NCT00459264)
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bipolar Disorder
A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder
This study will assess the adverse events and how oral ABBV-932 moves through the body when given with oral Itraconazole in adult participants with bipolar disorder.
- Trial name
- NCT07071532
- Testing
- ABBV-932, Itraconazole
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- AbbVie
Bipolar Disorder (BD)
Real-world Lithium Intake
The aim of the present study is to study compliance with lithium therapy and patterns of lithium intake among a representative group of patients with bipolar disorder in a real-world clinical setting.
- Trial name
- NCT07167563
- Testing
- Lithium (LI) based on clinical indication
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Bipolar, Manic
Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder
This study will be a randomized controlled trial (RCT) measuring the efficacy of wearing blue-blocking glasses (orange glasses) on manic symptoms in a population of patients suffering from Bipolar Disorder (BD), hospitalized for…
- Conditions
- Bipolar, Manic, Bipolar Disorder (BD), Dark Therapy
- Trial name
- BLUME (NCT06748716)
- Testing
- Blue-blocking glasses, Clear glasses
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- Rayan NASSERDINE
Schizophrenia, Schizoaffective Disorder
CLOZAPINE Response in Biotype-1
The CLOZAPINE study is designed as a multisite study across 5 sites and is a clinical trial, involving human participants who are prospectively assigned to an intervention.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar 1 Disorder
- Trial name
- NCT04580134
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 524 people
- Sponsor
- University of Texas Southwestern Medical Center
Bipolar Disorder, Bipolar and Related Disorders
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders
This study is testing whether a type of gentle brain stimulation, combined with computer-based brain training exercises, can help improve thinking skills in Veterans with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar and Related Disorders, Veterans, Suicide
- Trial name
- TACTIC-BD (NCT07845409)
- Testing
- Soterix 1x1 tES mini-CT
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
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