Clinical trials: bipolar
Ischemia, Stress, Mental
Neurocardiac Interactions Evaluated by Anatomic and Physiologic MRI Assessment
The purpose of project is to answer fundamental questions about the mechanisms underlying mental stress ischemia in patients with coronary artery disease, mood disorders, or both, and to identify potential biomarkers and…
- Trial name
- NIRVANA (NCT02962154)
- Testing
- Coronary CT Angiography, Mood Symptom Scale, Anxiety Symptom Scale
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Bipolar Disorder, Mania
Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Disorder
The objective of this study is to compare the safety and effectiveness of Ziprasidone in the treatment of mania in children and adolescents with Bipolar disorder over 8 weeks.
- Trial name
- NCT00181922
- Testing
- ziprasidone (Geodon)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
The purpose of this research study is to evaluate the safety, tolerability, and efficacy of quetiapine compared to placebo (sugar pill without medication) in the treatment of bipolar disorder with moderate to severe hypomania or…
- Trial name
- NCT00277667
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Lindner Center of HOPE
Bipolar I Disorder
Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode
Hypothesis: Continuation of an atypical antipsychotic medication in combination with a Mood Stabilizer, following remission from an acute manic episode, lowers the rates of relapse and recurrence of mood episodes compared to…
- Trial name
- NCT01977300
- Testing
- Valproate, Lithium, Risperidone
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- University of British Columbia
Depression, Bipolar Disorder
Liothyronine (T3) for Bipolar Depression
This study evaluates the efficacy of the thyroid hormone T3 for depression in patients with bipolar disorder. In this study patients will be randomized to receive T3 or placebo.
- Trial name
- T3 (NCT00790738)
- Testing
- Liothyronine (T3)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwell Health
Major Depression, Bipolar I Disorder
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and Drug Administration (FDA) but the investigators will use it for a…
- Conditions
- Major Depression, Bipolar I Disorder, Bipolar II Disorder, Unipolar Depression
- Trial name
- Bio-K (NCT03156504)
- Testing
- Ketamine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Schizophrenia, Bipolar Disorder
Individualizing Incentives for Alcohol in the Severely Mentally Ill
The investigators will evaluate the efficacy of a 2 various contingency management (CM) interventions (High-Magnitude CM, Shaping CM) for treating heavy drinking among individuals with serious mental illness and alcohol…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Alcohol Dependence
- Trial name
- NCT03481049
- Testing
- Usual CM, High-Magnitude CM, Shaping CM
- Where
- 2 sites in United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Washington State University
Mood Disorders, Healthy
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.
- Conditions
- Mood Disorders, Healthy, Unipolar Depression, Bipolar Depression
- Trial name
- NCT00055575
- Testing
- Scopolamine Nasal Spray
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Bipolar I Disorder
Children's Bipolar Network Treatment Trial I
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN).
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder, Other Specified Bipolar and Related Disorder
- Trial name
- CBN (NCT05427123)
- Testing
- Medication or psychosocial treatment
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Dementia, Bipolar Disorder (BD)
Lithium for Prevention of Cognitive Declining in Mood Illnesses
INTRODUCTION: Mood disorders, bipolar disorder and recurrent unipolar depression, are among the most common mental health conditions worldwide.
- Conditions
- Dementia, Bipolar Disorder (BD), Depression - Major Depressive Disorder, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06662526
- Testing
- Trace lithium dose plus treatment as usual
- Where
- 2 sites in Chile
- Volunteers
- 250 people
- Sponsor
- University of Chile
Bipolar Disorder
An Epidemiological Registry Study to Evaluate Clinical Practice Treatment in Patients With Bipolar Disorder
The aim of this study is to describe the treatment pattern and patient characteristics in real life setting in patients with Bipolar disorder treated with Seroquel XR and/or Seroquel IR in Sweden.
- Trial name
- REED (NCT01455961)
- Volunteers
- 16,000 people
- Sponsor
- AstraZeneca
Bipolar I Disorder
A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescents
The purpose of the study is to evaluate the long-term safety profile of the Investigational Medication Depakote ER in the treatment of Bipolar I Disorder, manic or mixed episode, in children and adolescents ages 10-17.
- Trial name
- NCT00195780
- Testing
- Divalproex Sodium (Depakote ER)
- Where
- 29 sites in United States
- Volunteers
- 227 people
- Sponsor
- Abbott
Bipolar Disorder
Study of Bipolar Disorders and Retinal Electrophysiological Markers
The BIMAR study aims to compare electrophysiological data measured with electroretinogram (ERG) and electroencephalogram (EEG) between a group of euthymic patients with bipolar disorder (BD) and a group of healthy controls…
- Trial name
- BIMAR (NCT05161546)
- Testing
- EEG and ERG measurements (Retinaute®, BioSerenity), Actigraphy (Motion Watch 8®, CamNtech), Neuropsychological assessments
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centre Psychothérapique de Nancy
Lithium Toxicities, Bipolar Disorder
Decline in Renal Concentration Ability in Lithium Treated Patients
Lithium therapy is cornerstone in therapy of bipolar disorders. A well known side-effect of lithium therapy is a urinary concentration defect which manifests in it's most severe form as nephrogenic diabetes insipidus.
- Conditions
- Lithium Toxicities, Bipolar Disorder, Concentration Ability Impaired, Nephrogenic Diabetes Insipidus
- Trial name
- NCT05307042
- Testing
- Deamino Arginine Vasopressin (dDAVP)
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Radboud University Medical Center
Dialectical Behavior Therapy + Pharmacotherapy, Standard of Care Psychotherapy + Pharmacotherapy
Dialectical Behavior Therapy (DBT) for Adolescents With Bipolar Disorder
Of all psychiatric diagnoses, bipolar disorder imparts the greatest risk for completed suicide in adolescence, and is further associated with poor psychosocial functioning, substance abuse and legal difficulties, and exorbitant…
- Trial name
- DBT (NCT02003690)
- Testing
- Dialectical Behavior Therapy, Standard of Care Psychotherapy, Pharmacotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Dual Diagnosis, Schizophrenia
Benefits Management for People With Psychiatric Disabilities
This stage 1 clinical trial will determine pilot efficacy, develop a therapy manual, and collect qualitative data concerning a brief money management intervention for people disabled by psychiatric illnesses.
- Conditions
- Dual Diagnosis, Schizophrenia, Bipolar Disorder
- Trial name
- NCT01329393
- Testing
- Benefits Management, Illness Management and Recovery
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Yale University
Symptomatic Bradycardia
Pacing Characteristics of a Conventional Bipolar
Study Title: Pacing characteristics of a conventional bipolar, active fixation pacing lead for left bundle branch area pacing in patients with symptomatic bradycardia Study Objectives: To characterize an approach for left bundle…
- Trial name
- NCT06011252
- Testing
- Solia S lead with any BIOTRONIK Pacemaker
- Where
- 5 sites in Taiwan
- Volunteers
- 134 people
- Sponsor
- Chang Gung Memorial Hospital
Bipolar I Disorder, Most Recent Episode Depressed
Neuronal Integrity in Bipolar Depression
The aim of this study is to examine the neurological unity in bipolar depression and to investigate white matter abnormalities that may contribute to etiology
- Trial name
- NCT04855409
- Volunteers
- 32 people
- Sponsor
- Mehmet Diyaddin Güleken
Humeral Shaft Fracture
Unipolar Versus Bipolar Interlocking in Humeral Shaft Fractures in Adults
Shaft fractures account for 20% of humeral fractures and 3% of all adult fractures in France, with an estimated incidence of 13 to 20/100,000 people.
- Trial name
- UNILOCH (NCT05877014)
- Testing
- questionnaires, scanner
- Where
- France
- Volunteers
- 390 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Schizophrenia, Bipolar Disorder
Impact of Genetic Counseling for Individuals With Mental Illness
People who have experienced mental illnesses like schizophrenia, bipolar disorder or schizoaffective disorder often have a poor understanding of the causes of their illness, and that they are often very worried about how the…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT00713804
- Testing
- Genetic Counseling, Educational Booklet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
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