Clinical trials: cGvHD
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Safety Study of an Immunomodulating Microparticle to Treat Progressive Multiple Sclerosis
The purpose of the study is to determine the safety and tolerability, dose-limiting toxicities, maximum tolerated dose, and recommended therapeutic dose of intravenously administered MIS416 weekly in patients with chronic…
- Trial name
- NCT01191996
- Testing
- MIS416
- Where
- New Zealand
- Volunteers
- 34 people
- Sponsor
- Innate Immunotherapeutics
Myeloid Leukemia, Chronic
A Study of Dasatinib in Chronic Phase Philadelphia Chromosome Positive Chronic Myeloid Leukemia
The objective is to evaluate the cytogenetic response to Dasatinib (BMS-354825) administered for 24 weeks in subjects with Imatinib resistant or intolerant chronic phase chronic myeloid leukemia (CML) once daily (QD) or twice…
- Trial name
- NCT00482703
- Testing
- Dasatinib
- Where
- 9 sites in Japan
- Volunteers
- 23 people
- Sponsor
- Bristol-Myers Squibb
Acute Steroid Responsive Dermatoses, Chronic Steroid Responsive Dermatoses
An Investigator-Initiated Study to Assess the Cooling Effect of Triamcinolone Acetonide Aerosol When Used for Steroid-Responsive Dermatoses
Triamcinolone acetonide is a mid-potency, class 4/5 topical corticosteroid that is available in a spray formulation (Triamcinolone Acetonide Spray, T Spray).
- Trial name
- NCT01736670
- Testing
- Triamcinolone Acetonide spray, Triamcinolone acetonide cream, Alcohol spray
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Patel, Rita Vikram, M.D.
Migraine Disorders, Chronic Migraine
Biochemical Profiling of Migraine Patients
Aim of the study was to assess a potential dysfunction of the endocannabidiome system (eCBome) in migraine patients. Migraine patients who will undergo preventive therapy with monoclonal antibodies directed against the calcitonin…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_1 (NCT06549270)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Chronic Heart Failure
Novel Vascular Biomarkers Behaviour and Clinical Value in Heart Failure and CRT
The purpose of this study is to understand the behaviour of certain blood markers in patients with heart failure who undergo a cardiac device implantation procedure called cardiac resynchronization therapy (CRT).
- Trial name
- COVERT-HF (NCT02541773)
- Testing
- Cardiac Resynchronisation Therapy
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Chronic Obstructive Pulmonary Disease (COPD)
Intermittent Intrapulmonary Deflation and Dyspnea Following Exercise in People With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a long-term lung condition that causes breathing difficulties. People living with this disease often feel short of breath, especially during physical activity, which can make daily tasks…
- Trial name
- DEFLA-DYSPNEA (NCT06956742)
- Testing
- Active intermittent intrapulmonary deflation.
- Where
- France
- Volunteers
- 33 people
- Sponsor
- ADIR Association
Chronic Hepatitis b
The Effect of Metabolic Syndrome on Antiviral Response in People With Chronic Hepatitis B
Chronic hepatitis B (CHB) affects an estimated 292 million people, and causes approximately 800,000 people deaths per year from liver-related complications including cirrhosis and hepatocellular carcinoma, remaining a major…
- Trial name
- NCT05705141
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Chronic Obstructive Pulmonary Disease
Long-term Maintenance Benefits of a Pulmonary Rehabilitation Program Using a Mobile Digital Solution: a Prospective, Randomized, Controlled, Multicenter Study in a Population of COPD Patients
Chronic obstructive pulmonary disease (COPD) is a public health problem: high prevalence; increasing morbidity and mortality; impact on health costs.
- Trial name
- m-Rehab COPD (NCT04550741)
- Testing
- telerehabilitation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Heart Failure
iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure.
- Trial name
- iCardia4HF (NCT06205225)
- Testing
- Text4HF, MyApps, MyApps & Text4HF
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- University of Illinois Chicago
Pain, Opioid Use
Microcurrent Treatment for Chronic Debilitating Pain
To compare the efficacy of standard pain treatment and placebo (a microcurrent faux treatment) as opposed to standard pain treatment and microcurrent therapy in any primary care patients over a three month period.
- Trial name
- NCT04011176
- Testing
- Standard treatment + Microcurrent Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Paul Crawford
Musculoskeletal Pain, Chronic Pain
Living in Full Even With Pain Study
This project will increase our understanding of the mechanisms underlying changes in opioid medication use associated with three psychosocial chronic pain (CP) treatments.
- Trial name
- LIFE (NCT03916276)
- Testing
- Cognitive Therapy (CT), Mindfulness Meditation (MM), Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Washington
Hyperphosphatemia in Chronic Kidney Disease
Efficacy of Phosphate Binding in Healthy Volunteers: Chewed Versus Crushed Lanthanum Carbonate
Patients with end-stage renal disease (ESRD) commonly have high concentrations of phosphorous, a mineral, in the blood (hyperphosphatemia). This is a result of their inability to excrete phosphorous by the kidneys.
- Trial name
- NCT00458289
- Testing
- Lanthanum carbonate (chewed vs. crushed)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Chronic Periodontitis, Generalized
Flapless Emdogain in the Treatment of Periodontal Residual Pockets
48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for…
- Trial name
- NCT05823389
- Testing
- Re-instrumentation with flapless Emdogain application
- Where
- Palestinian Territories
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Stroke, Upper Extremity Paresis
Improving Arm and Hand Functions in Chronic Stroke (CIHR 2012-2015)
Improving arm and hand function after stroke has been difficult to achieve within the rehabilitation service provided in the acute stage often due to the limited resource in health care.
- Trial name
- NCT01721668
- Testing
- Music Supported Rehabilitation, Conventional Upper Extremity Therapy
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Baycrest
Hypertension
The Effect of the Patient Activation Measure on Chronic Care
We will test - in a chronically ill managed long term care population - the effectiveness of an intervention that provides nurse Care Managers with an inventory of evidence-based practices tailored to patients with different…
- Trial name
- NCT00299468
- Testing
- Patient Activation Measure Intervention Package
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Weill Medical College of Cornell University
Force Measurement, Electromyography
Knee Neuromuscular Assessment in Children With Cerebral Palsy
The purpose of this study is to evaluate the reliability (intra-rater and inter-rater) of the K-Pull dynamometer and the K-Myo non-invasive electromyography sensor (assessing neuromuscular activity) in the evaluation of the lower…
- Conditions
- Force Measurement, Electromyography, Children, Cerebral Palsy
- Trial name
- NCT06667518
- Testing
- Neuromuscular Activity Assessment
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Thessaly
Reproductive Disorder, Neurodegeneration
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome.
- Conditions
- Reproductive Disorder, Neurodegeneration, SARS-CoV 2, Long COVID
- Trial name
- NCT07224490
- Testing
- Kisspeptin 112-121
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stephanie B. Seminara, MD
Critical Limb Ischemia
ACP-01 in Patients With Critical Limb Ischemia
The primary objective of this study is to determine the efficacy and safety of intramuscular injection of ACP-01, comprised of blood-derived autologous ACPs, in subjects with critical limb ischemia who are receiving standard of…
- Trial name
- NCT02551679
- Testing
- ACP-01
- Where
- 19 sites in United States, Canada
- Volunteers
- 67 people
- Sponsor
- Hemostemix
Postherpetic Neuralgia, Chronic Pain
Efficacy of Transcutaneous Pulsed Radiofrequency in Postherpetic Neuralgia
Postherpetic neuralgia (PHN) is a chronic pain syndrome that may be resistant to treatment and can lead to physical and social disability as well as psychological disturbances, persisting for years in some patients.
- Conditions
- Postherpetic Neuralgia, Chronic Pain, Neuropathy
- Trial name
- NCT07390279
- Testing
- Transcutaneous Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Chronic Kidney Disease, Hyperparathyroidism, Secondary
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
This study will evaluate the efficacy of CTAP101 Capsules versus placebo in reducing intact parathyroid hormone (iPTH) by at least 30% from pretreatment baseline; safety and tolerability of CTAP101 will also be evaluated
- Conditions
- Chronic Kidney Disease, Hyperparathyroidism, Secondary, Vitamin D Deficiency
- Trial name
- NCT01704079
- Testing
- CTAP101 30 μg capsules, Sugar pill to CTAP101 30 μg capsules
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- OPKO IP Holdings II, Inc.