Clinical trials: fMRI
Cerebral White Matter Lesions
MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and…
- Trial name
- NCT02276976
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei Wang
Fibromyalgia
The Effect of Autoreactive Autoantibodies on Peripheral and Central Disease Mechanisms in Fibromyalgia.
This observational study aims to compare disease burden and pain characteristics between fibromyalgia patients with high levels of autoreactive autoantibodies, fibromyalgia patients with low levels of autoreactive autoantibodies…
- Trial name
- FINE (NCT07346950)
- Where
- Sweden
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Depression
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evidence that goes beyond self-report.
- Trial name
- TBO-II (NCT06817993)
- Testing
- Rejection and Acceptance Feedback
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Alcoholism
Oxytocin in Alcohol Use Disorder
Background: Oxytocin is a naturally occurring substance in the body. Studies show that oxytocin may affect how the body responds to alcohol. Researchers believe oxytocin may be a possible treatment for alcoholism.
- Trial name
- NCT02711189
- Testing
- Oxytocin
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Primary Progressive Aphasia
Transmagnetic Stimulation Pilot in Primary Progressive Aphasia
Frontotemporal degeneration (FTD) is a non-Alzheimer's dementia that is the 2nd most common cause of dementia in the United States.
- Trial name
- TMS in PPA (NCT05860647)
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- HealthPartners Institute
Mild Cognitive Impairment
Cognitive Training in Patients With MCI Using fMRI
The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls…
- Trial name
- NCT03263247
- Testing
- Visual Memory Training, Alphabet search
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Cognitive Performance
Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training
The overall objective is to identify the cognitive circuits associated with military aviator performance by analyzing what anatomic regions of the brain are functionally "active" (neuronal circuit) while being performing virtual…
- Trial name
- fMRI Pilots (NCT06606925)
- Testing
- fMRI with virtual reality flight simulator
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- The Geneva Foundation
Healthy
Imaging During Subliminal Perception
Subliminal perception of visual stimuli can be studied with functional brain imaging, e.g. with functional magnetic resonance imaging (fMRI). However, it is unclear how subliminal perception affects connectivity in the brain.
- Trial name
- NCT04643340
- Testing
- real-time fMRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Focus: Effects of Nicotine and Alcohol on Brain Circuits
Neural Mechanisms Underlying Nicotine and Alcohol Combinations
Nicotine and alcohol are frequently used together and their combined use contributes to more than half a million deaths each year, with more alcoholics dying from smoking-related diseases than from alcohol-related diseases.
- Trial name
- QfMRI (NCT02049268)
- Testing
- Nicotine + Alcohol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Limb Dystonia, Idiopathic Dystonia
Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia
The goal of this clinical trial is to find out if a non-invasive procedure called focused ultrasound can safely and effectively treat limb dystonia in adults who have not improved with medications or botulinum toxin injections.
- Conditions
- Limb Dystonia, Idiopathic Dystonia, Medication-refractory Dystonia, Dystonia, Focal
- Trial name
- FUTURE (NCT07168850)
- Testing
- Exablate MR-guided Focused Ultrasound Pallidotomy
- Where
- 4 sites in Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Healthy Females, Vagus Nerve Stimulation
Effects of tVNS on Visceral Pain
Transcutaneous auricular vagal nerve stimulation (taVNS) has shown promise in reducing chronic abdominal pain, such as in irritable bowel syndrome (IBS).
- Conditions
- Healthy Females, Vagus Nerve Stimulation, Abdominal Pain
- Trial name
- NCT06659172
- Testing
- taVNS
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bulimia Nervosa, Binge-Eating Disorder
Effects of Negative Affect in Individuals With Binge Eating Episodes
Binge-eating is characterized by recurrent episodes of eating large amounts of - typically high calorie - foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as feeling disgusted with…
- Conditions
- Bulimia Nervosa, Binge-Eating Disorder, Obesity, Eating Disorder
- Trial name
- NCT03393039
- Testing
- Negative Affect Task
- Where
- United States
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Speech, Motor Activity
Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning
These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.
- Trial name
- BRAVA² (NCT04547569)
- Testing
- Speech adaptation, Vibrotactile Discrimination, fMRI
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Anhedonia, Cognitive Function
Pitolisant Effects on Affect and Cognition Exploratory Study (PEACE Study)
The goal of this study is to investigate the effects of selective histamine 3 antagonist pitolisant on brain function and cognition in healthy individuals. The main questions it aims to answer are: 1.
- Trial name
- PEACE (NCT05849675)
- Testing
- Pitolisant 17.8 MG [Wakix]
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Chronic Ankle Instability, CAI, Functional Magnetic Resonance Imaging (fMRI)
fMRI Study on Cerebral Localization and Network Mechanisms of rTMS in Chronic Ankle Instability Treatment
Chronic ankle instability (CAI) is a common sports injury that often leads to recurrent injuries and functional deficits. While conventional rehabilitation can restore ankle stability, the underlying neurophysiological mechanisms…
- Trial name
- NCT06971705
- Testing
- repetitive transcranial magnetic stimulation, rTMS, ankle stability training
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wuhan University
Healthy
Chatbot Intervention Effects on Emotional Arousal in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on affective arousal in college students with elevated levels of depression and anhedonia by…
- Trial name
- NCT07671131
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Sleep Deprivation
fMRI-behavioral Study of Cholinergic Augmentation With Donepezil in Healthy Sleep Deprived Adults
The purpose of this study was to characterize how the anti-cholinesterase inhibitor (AChE-I) donepezil modulates brain regions involved in visual short-term memory, episodic memory and inhibitory efficiency following 24 hours of…
- Trial name
- NCT00800553
- Testing
- donepezil
- Where
- Singapore
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Anesthesia
EEG-fMRI Experiments During Anesthesia Induction With Propofol
This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol.
- Trial name
- NCT06179719
- Testing
- Propofol, visual flickering stimulation at the alpha frequency
- Where
- 2 sites in Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Healthy
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
- Trial name
- NCT05525845
- Testing
- Functional Magnetic Resonance Imaging (pCASL-MRI), Intragastric Balloon, Elemental Meal
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford