Clinical trials: fMRI, open to volunteers
Writer's Cramp
Video-supervised Motor and Awareness Training in Writer's Cramp
Writer's cramp is the most common task-specific dystonia. It is characterized by involuntary co-contraction of antagonistic muscles during writing. This disabling condition may force patients to give up their occupation.
- Trial name
- NCT04611009
- Testing
- motor training, mindfulness exercises
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University Hospital Schleswig-Holstein
Normal Physiology
Development and Validation of Learning and Decision-Making Tasks
Background: Substance use disorders (SUD) can be considered disorders in the way people process incentives, learn, and make decisions.
- Trial name
- NCT05707806
- Testing
- MRI
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Depressive Symptoms, Mild Traumatic Brain Injury
rTMS for Military TBI-related Depression
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in…
- Conditions
- Depressive Symptoms, Mild Traumatic Brain Injury, Concussion
- Trial name
- ADEPT (NCT05426967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 198 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
ADHD, Obsessive Compulsive Disorder (OCD)
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
Background: Attention deficit hyperactivity disorder (ADHD) is common in children. It can cause problems with attention and the ability to control actions and impulses.
- Conditions
- ADHD, Obsessive Compulsive Disorder (OCD), Healthy Volunteer
- Trial name
- NCT07566468
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Limb Dystonia, Idiopathic Dystonia
Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia
The goal of this clinical trial is to find out if a non-invasive procedure called focused ultrasound can safely and effectively treat limb dystonia in adults who have not improved with medications or botulinum toxin injections.
- Conditions
- Limb Dystonia, Idiopathic Dystonia, Medication-refractory Dystonia, Dystonia, Focal
- Trial name
- FUTURE (NCT07168850)
- Testing
- Exablate MR-guided Focused Ultrasound Pallidotomy
- Where
- 4 sites in Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Autism Spectrum Disorder
pBFS Guided rTMS Over Cognitive Control Network for ASD
The aim of this trial is to assess the efficacy and safety of precision neuromodulation for alleviating core symptoms in patients with autism spectrum disorder (ASD) who also have intellectual or developmental delay.
- Trial name
- NCT06255535
- Testing
- active iTBS treatment
- Where
- 6 sites in China
- Volunteers
- 215 people
- Sponsor
- Changping Laboratory
Healthy
Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive…
- Trial name
- NCT07665216
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Alcohol Use Disorder
Neural and Hormonal Influences on Sex Differences in Risk for AUD
The sex gap in alcohol consumption is closing rapidly, due to alarming increases among women. From 2002-2013, Alcohol Use Disorder (AUD) increased 84% for women, compared to 35% for men.
- Trial name
- NCT04929288
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jessica Weafer
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
The goal of this clinical trial is to investigate the clinical efficacy of repetitive transcranial magnetic stimulation in the treatment of achalasia in patients diagnosed with achalasia by comprehensive evaluation of clinical…
- Conditions
- Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive, Vagus Nerve Motor Disorder, Functional Magnetic Resonance Imaging
- Trial name
- NCT06027190
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhang Nina
ADHD
Impact of Stimulants and In-Scanner Motion on Attentive Task Performance in ADHD (ADHD_NFB)
The goal of this interventional study is to learn the effects that stimulant medication prescribed to ADHD individuals has in their performance of attentive tasks, as measured by images and data collected through neuroimaging…
- Trial name
- ADHD_NFB (NCT06779825)
- Testing
- fMRI Neurofeedback attention task
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Epilepsy
RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy
Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks.
- Trial name
- RESPIRE (NCT04451278)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke
Effects of Cerebrospinal Fluid Drainage on Cerebral Hemodynamics
This pilot interventional study investigates whether continuous cerebrospinal fluid (CSF) drainage via lumbar drain can improve cerebrovascular reactivity (CVR) in patients with acute ischemic stroke and hemodynamic failure, as…
- Trial name
- NCT07056907
- Testing
- Lumbar drain placement
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Obsessive-Compulsive Disorder (OCD)
Preliminary Explorative Study of Magnetic Resonance-Guided Focused Ultrasound Surgery in Refractory Obsessive-Compulsive Disorder Patients
The goal of this clinical trial is to evaluate If magnetic resonance-guided focused ultrasound works to treat refractory obsessive-compulsive disorder in adults.
- Trial name
- NCT06816511
- Testing
- magnetic resonance-guided focused ultrasound surgery, MRgFUS
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Hippocampal Hyperactivation, Prodromal Alzheimer Disease
Levetiracetam for Persons at Risk for Alzheimer's Disease
The goal of this clinical trial is to investigate whether very small doses of a drug called levetiracetam (LEV) may reduce elevated brain signaling in individuals who are at an increased risk for developing Alzheimer's Disease…
- Trial name
- ALEVIATE-2 (NCT07477431)
- Testing
- Levetiracetam (LEV)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics
This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.
- Conditions
- Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07819162
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Multifocal HD-tDCS and Motor Function
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain…
- Trial name
- NCT06561165
- Testing
- Standard HD-tDCS intervention, Multifocal network targeted HD-tDCS intervention, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gambling Addiction
Testing the Interplay of Gambling, Emotion and Reward
Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual…
- Trial name
- TIGER (NCT06122298)
- Testing
- fMRI, Ecological Momentary Assessment
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
THC
Pilot fMRI Studies of Aging-Related Effects of THC
The purpose of this study is to begin investigating acute impairment of various forms of memory and learning by Tetrahydrocannabinol (THC) in cannabis (CNB) compared to placebo, in a 2-session per subject double-blind, random…
- Trial name
- NCT06647524
- Testing
- THC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University