Clinical trials: for Brain Tumors
Brain Metastases, Adult
Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases
Immunotherapy treatments are intended to boost a person's immune system to fight their cancer. Treatment with immunotherapy has been shown to be effective in a wide range of cancers, including melanoma skin cancer, lung cancer…
- Trial name
- ACT-FAST (NCT04461418)
- Testing
- Glucocorticoid therapy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- AHS Cancer Control Alberta
Metastases of Central Nervous System, Melanoma
Study to Evaluate the Efficacy and Safety of Temozolomide in Subjects With Brain Metastases of Either Malignant Melanoma, Breast, or Non-small Cell Lung Cancer (P02064)
The study implies a 2 step study design. Patients are enrolled into 3 separate groups for melanoma, breast, and non-small cell lung cancer. In the first step, 21 patients per disease group are enrolled.
- Conditions
- Metastases of Central Nervous System, Melanoma, Breast Neoplasm, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT00831545
- Testing
- Temozolomide
- Volunteers
- 162 people
- Sponsor
- Merck Sharp & Dohme LLC
Metastatic Malignant Neoplasm to the Adult Brain
Robotic Compared to Fixed Gantry Radiosurgery for Brain Metastases
Radiosurgery is precisely delivered high dose radiation. It can be performed using multiple cobalt sources, a modified traditional gantry-based linear accelerator or a robotic linear accelerator.
- Trial name
- TRICK (NCT01353573)
- Testing
- Fixed Gantry Radiosurgery, Robotic Radiosurgery
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation
Dementia, Cognitive Impairment, Mild
Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial
Cognitive Stimulation Therapy (CST) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia.
- Conditions
- Dementia, Cognitive Impairment, Mild, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05860127
- Testing
- Referral for Cognitive Stimulation Therapy, No change to Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Massachusetts, Amherst
Pituitary Adenoma
OCT-angiography as a Pronostic Marker for Visual Impairment in Patients Undergoing Neurosurgery for Compressive Macroadenoma : a Prospective Study.
The aim of the study is to assess accurancy of OCT angiography as a pronostic marker for patients undergoing neurosurgery for compressiver macroadenoma as compared with visual acuity, visual field and OCT.
- Trial name
- FIRST (NCT04074642)
- Testing
- Neurosurgery
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Brain Neoplasms
FLT-PET Imaging of Brain Tumors in Children
Brain tumors are the leading cause of death from solid tumors in children. Tumor imaging is important in the management of these tumors, but current imaging methods have limitations in providing the necessary information for…
- Trial name
- NCT01244737
- Testing
- [18F] FLT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Frederick Daniel Grant
Glioma
Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00795665
- Testing
- bevacizumab, carmustine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, Davis
Children With Cancer
Research on the Influence of Mukbang on Brain Activation in Children With Cancer Based on fMRI
This study aims to use the intervention study method to extract and verify the effective ingredients in Mukbang that promote appetite and eating in children with tumor during radiotherapy and chemotherapy, and to analyze and…
- Trial name
- NCT05922566
- Testing
- fMRI + Mukbang videos
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Oncolytic Virus, Diffuse Intrinsic Pontine Glioma
Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
This is a drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in primary DIPG patients…
- Conditions
- Oncolytic Virus, Diffuse Intrinsic Pontine Glioma, Adverse Drug Event
- Trial name
- NCT05717712
- Testing
- Ad-TD-nsIL12
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Brain Tumor
Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy
Certain kind of neurosurgical procedures require intraoperative alertness of the patient, for example to perform speech tests during brain tumor resection.
- Trial name
- NCT01128465
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bonn
Glioblastoma
Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.
The main goal of ORGA-GLIO trial is to establish the feasibility in routine clinical practice of ex-vivo organoid cultures composed of tumor cells within their microenvironment (glioblastoma organoid - GBO) and intra- and…
- Trial name
- ORGA-GLIO (NCT07029100)
- Testing
- Ex-vivo organoid culture
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment.
- Conditions
- Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children, Perioperative/Postoperative Complications, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00258453
- Testing
- metabolic assessment, physiologic testing, biopsy
- Where
- 109 sites in Austria, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Brain Metastases, Adult
Multi-disciplinary Care for Brain Metastases
This is a health services intervention study aimed at understanding the impact of intensive multi-disciplinary care compared with standard care on patient-reported symptom outcomes and prognostic awareness in patients with brain…
- Trial name
- NCT06280300
- Testing
- health services intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Vermont Medical Center
Rare CNS Tumor, FOXR2-activated
Ultra-Rapid Profiling and Drug Screening for Treatment Selection in Patients With Relapsed or Recurrent Rare Brain Tumors
The current study will use a new treatment approach based on the molecular characteristics of each participant's tumor. The study will test the feasibility in of performing real-time drug screening on tissue taken during surgery…
- Conditions
- Rare CNS Tumor, FOXR2-activated, BCOR ITD Sarcoma, CNS Sarcoma
- Trial name
- SUPERNOVA-RBT (NCT07851636)
- Testing
- Personalized Treatment Recommendation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Adriana Fonseca
Brain and Central Nervous System Tumors
Gefitinib Plus Temozolomide in Treating Patients With Malignant Primary Glioma
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of cancer cells and slow the growth of the tumor.
- Trial name
- NCT00027625
- Testing
- gefitinib, temozolomide
- Where
- 11 sites in United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer With Brain Metastasis, HER2-positive Breast Cancer
T-DXd With or Without Neratinib for HER2 Positive Breast Cancer With Brain Metastasis
A phase II, open-label, multicenter, randomized controlled trial exploring the efficacy and safety of Trastuzumab Deruxtecan combined with or without Neratinib in HER2-positive breast cancer with brain metastasis
- Trial name
- THUNDER (NCT07152782)
- Testing
- Neratinib, Trastuzumab Deruxtecan
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Fudan University
Brain Neoplasms, Brain Cancer
Optimal Planning Target Volume With Stereotactic Radiosurgery
The purpose of this study is to estimate the rate of local control at the treated site of the metastasis as a function of 1mm versus 3mm expansion about the gross tumor volume (GTV).
- Trial name
- NCT01017497
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Duke University
Glioblastoma, Gliosarcoma
BIBF 1120 for Recurrent High-Grade Gliomas
BIBF 1120 is a newly discovered compound that may stop cancer cells from growing abnormally. This drug is currently being used in treatment for other cancers in research studies and information from those other research studies…
- Conditions
- Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- NCT01380782
- Testing
- BIBF 1120
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Patrick Y. Wen, MD
Acromegaly, Pituitary Neoplasm
Sandostatin LAR Depot vs. Surgery for Treating Acromegaly
The purpose of this study is to compare the efficacy of Sandostatin LAR® (Registered Trademark) Depot to transsphenoidal surgery in previously untreated acromegalic patients with macroadenomas.
- Trial name
- NCT00001860
- Testing
- Sandostatin LAR Depot versus transsphenoidal surgery
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non Small Cell Lung Cancer Metastatic
Temozolomide Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost for Non Small Cell Lung Cancer Brain Metastases
With the improvement of systemic therapeutic effect(especially in the population with driver gene mutation), the incidence of brain metastases had significantly increased.
- Trial name
- NCT03732482
- Testing
- Temozolomide capsules, radiotherapy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Taizhou Hospital
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