Clinical trials: for Brain Tumors
Cancer
Whole Brain Radiation With or Without Erlotinib for Brain Metastases From Non-Small Cell Lung Cancer
To determine if erlotinib given orally along with concurrent whole brain irradiation in lung cancer patients with brain metastases improves median overall survival and enhances local control compared to those treated with WBRT…
- Trial name
- RadEr (NCT01518621)
- Testing
- Radiation, Radiation plus erlotinib
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Oslo University Hospital
Dravet Syndrome, Lennox Gastaut Syndrome
Intermediate-Size Expanded Access Protocol (EAP) for LP352
This is an intermediate-size expanded access program (EAP) study. The purpose of this EAP is to provide continued access to LP352, an investigational drug product being investigated in participants with DEEs.
- Conditions
- Dravet Syndrome, Lennox Gastaut Syndrome, Developmental and Epileptic Encephalopathies
- Trial name
- NCT06149663
- Testing
- LP352
- Where
- 22 sites in United States, Australia
- Sponsor
- Longboard Pharmaceuticals
Brain Metastases, Adult
Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases
This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.
- Trial name
- SUPPORT (NCT05545007)
- Testing
- Hypofractionated Radiosurgery (HSRS), Brain metastases surgical resection
- Where
- 9 sites in Italy
- Volunteers
- 146 people
- Sponsor
- Istituto Clinico Humanitas
Brain Tumor
Upright Open MRI for Brain Imaging in Children - a Pilot Study
PRIMARY OBJECTIVE To establish feasibility and acceptability of diagnostic brain MRI in young children for specified indications using an upright MRI system without sedation or anaesthesia.
- Trial name
- Heads-Up (NCT06257498)
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Recurrent High Grade Meningioma
Trabectedin for Recurrent Grade II/III Meningioma
The aim of this study is to collect data on activity, toxicity and quality of life of trabectedin therapy in patients with recurrent high-grade meningioma.
- Trial name
- NCT02234050
- Testing
- Trabectedin, Local standard of care
- Where
- 47 sites in Austria, Belgium and 8 more
- Volunteers
- 90 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Brain Tumor, Recurrent Brain Tumor
Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements
This study investigates the role of intraoperative shear wave elastography ultrasound (ISWEU) in identifying healthy brain and tumor tissue stiffness differences. This data may be used to guide tumor resection in future patients.
- Conditions
- Brain Tumor, Recurrent Brain Tumor, Brain Neoplasm, Recurrent Brain Neoplasm
- Trial name
- NCT06630338
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Brain Edema Caused by Drugs, Cerebral Oxygenation
Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome
The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor's underlying pathophysiology including brain…
- Trial name
- TIVolBrain (NCT06779890)
- Testing
- Sevoflurane, Desflurane
- Where
- 2 sites in Greece
- Volunteers
- 84 people
- Sponsor
- Georgia Tsaousi
Advanced Cancer
DM-CHOC-PEN Plus Radiation for Brain Tumors
4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial…
- Trial name
- NCT03371004
- Testing
- 4-Demethyl-4-cholesteryloxycarbonylpenclomedine
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- DEKK-TEC, Inc.
Malignant Brain Tumors
PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors
The purpose of this pilot study is to investigate the feasibility of an early palliative care intervention (PRESENCE: Providing Resources Education, Support, and Enabling New brain tumor patients to Cope Effectively) and the…
- Trial name
- NCT01652768
- Testing
- Research Questionnaires, Palliative Care Team, Educational Information Session for Patients and Caregivers
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Glioblastoma, High-Grade Glioma (WHO III-IV)
Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients
This is an open label, single arm, prospective, and pilot study. Eligible patients will be enrolled after acquiring the signed informed consent and then will receive the treatment of re-RT combined with FUS (FUS + re-RT) on an…
- Conditions
- Recurrent Glioblastoma, High-Grade Glioma (WHO III-IV), Brain Tumor Recurrent, Brain Tumor Adult
- Trial name
- NCT04988750
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- NaviFUS Corporation
Brain Tumors
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
The study PNET 5 MB has been designed for children with medulloblastoma of standard risk (according to the risk-group definitions which have been used so far; e.g. in PNET 4).
- Trial name
- NCT02066220
- Testing
- Radiotherapy without Carboplatin, Reduced-intensity maintenance chemotherapy, Radiotherapy with Carboplatin
- Where
- 77 sites in Austria, Belgium and 14 more
- Volunteers
- 360 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vascular; Lesion, Central Nervous System, Brain Tumor
Intraoperative Fluorescence With Augmented Reality
This is a study looking at a new way to evaluate vascular problems or tumors in brain surgery patients using a standard \& approved intravenous dye and augmented reality.
- Conditions
- Vascular; Lesion, Central Nervous System, Brain Tumor, Cerebral Aneurysm, Cerebral AVM
- Trial name
- NCT03888014
- Testing
- GLOW800, indocyanine green (ICG)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cedars-Sinai Medical Center
High Grade Glioma
Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas
The investigators of this study want to see if shortening the total treatment time for brain tumors is safe.The treatment for participant's brain tumors is laser surgery (Laser Interstitial Thermal Therapy (LITT)) followed by…
- Trial name
- NCT02970448
- Testing
- LITT, Radiation therapy, Temozolomide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Non Small Cell Lung Cancer (NSCLC)
A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC
This is a Phase I/II, Open Label Study of WSD0922-FU in Combination with Osimertinib for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer whose disease has progressed with third-generation EGFR-TKI with…
- Trial name
- WAYWIN103 (NCT07206498)
- Testing
- Osimertinib (Tagrisso®), WSD0922-FU
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Wayshine Biopharm, Inc.
Recurrent Childhood CNS Tumor, Ependymoma, Recurrent Childhood
COZMOS:Phase I/Ib Trial of Combined 5'Azacitidine and Carboplatin for Recurrent/Refractory Pediatric Brain/Solid Tumors
Many pediatric brain and solid tumors have altered epigenetic landscapes, and altered DNA methylation. As such this study is a Phase I/Ib study of combined 5'Azacitidine with an escalating dose of carboplatin for all…
- Conditions
- Recurrent Childhood CNS Tumor, Ependymoma, Recurrent Childhood, Childhood Solid Tumor
- Trial name
- COZMOS (NCT03206021)
- Testing
- 5 Azacytidine
- Where
- 17 sites in United States, Australia and 1 more
- Volunteers
- 31 people
- Sponsor
- The Hospital for Sick Children
Melanoma, Renal Cell Carcinoma
A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection
The purpose of this study is to collect prospective data for use as a comparator for future subsequent studies attempting to increase the efficacy or reduce the toxicity of gamma knife radiosurgery.
- Conditions
- Melanoma, Renal Cell Carcinoma, Sarcoma, Breast Cancer
- Trial name
- NCT02005614
- Testing
- Gamma Knife Radiosurgery
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Yale University
Glioblastoma, Brain Tumor
Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma
Patients may participate in this research study if they have glioblastoma. (a brain tumor) that has come back after being treated. Standard treatment for this cancer is a chemotherapy drug called bevacizumab.
- Trial name
- NCT02768389
- Testing
- Bevacizumab, Modified Atkins Diet
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Brain Metastases
Pre- Versus Post-operative SRS for Resectable Brain Metastases
The purpose of this study is to determine if performing radiotherapy (SRS) prior to surgery results in better treatment outcomes than performing surgery before radiotherapy for patients with brain metastases.
- Trial name
- NCT04474925
- Testing
- Brain Surgery, Stereotactic Radiosurgery
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- AHS Cancer Control Alberta
Glioblastoma, Brain Neoplasm
Bevacizumab With or Without Surgery for Adult Glioblastomas
Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Patients with GBM are usually treated with surgery, radiation, and chemotherapy. Despite this treatment, most GBMs start growing again.
- Trial name
- NCT01413438
- Testing
- Craniotomy
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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