Clinical trials: for Brain Tumors
Non Small Cell Lung Cancer (NSCLC)
A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC
This is a Phase I/II, Open Label Study of WSD0922-FU in Combination with Osimertinib for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer whose disease has progressed with third-generation EGFR-TKI with…
- Trial name
- WAYWIN103 (NCT07206498)
- Testing
- Osimertinib (Tagrisso®), WSD0922-FU
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Wayshine Biopharm, Inc.
Brain Metastases
Study of Temozolomide to Treat Newly Diagnosed Brain Metastases
The purpose of this study is to determine if administering temozolomide after completion of stereotactic radiosurgery helps control existing brain metastases and prevents the developement of new brain metastases.
- Trial name
- NCT00717275
- Testing
- Temozolomide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Non-Small Cell Lung Cancer, Brain Metastasis
Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer
This is a non-randomized open-label uncontrolled phase II trial evaluating efficacy and toxicity of gefitinib in patients with asymptomatic advanced NSCLC who was benefitted by first line chemotherapy.
- Trial name
- NCT00614809
- Testing
- gefitinib
- Volunteers
- 45 people
- Sponsor
- Guangdong Provincial People's Hospital
Solid Tumor Leptomeningeal Metastasis
A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis
The goal of this prospective, single-arm exploratory clinical study is to explore the safty and efficacy of whole-brain radiotherapy combined with Thiotepa intrathecal injection combined with systemic therapy for the primary…
- Trial name
- NCT06376292
- Testing
- Intrathecal Injection of Thiotepa+Radiation+Systemic Treatment of Primary Diseases
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glioma, Glioblastoma
A Study for Cerebral Open Flow Microperfusion
The purpose of this study is to evaluate the safety and feasibility of intra-operative microperfusion during a planned neurosurgical resection of diseased brain parenchyma, including either an epileptic focus requiring temporal…
- Trial name
- NCT07089758
- Testing
- Cerebral open flow microperfusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Glioblastoma, Adult
Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9
Recurrent glioblastoma (GBM) is a disease with high unmet clinical need. The standard of care for patients with GBM includes surgery, radiotherapy and chemotherapy.
- Trial name
- SC9-GBM-01 (NCT03744026)
- Testing
- SonoCloud-9, Carboplatin
- Where
- 6 sites in United States, France
- Volunteers
- 38 people
- Sponsor
- CarThera
Brain Metastasis
Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases
The purpose of this study is to determine if WBRT combined with SRS resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.
- Trial name
- NCT00406835
- Testing
- Whole-Brain Radiation Therapy, Stereotactic Radiosurgery
- Where
- Japan
- Volunteers
- 180 people
- Sponsor
- Hokkaido University Hospital
Brain Tumor
Real-time Assessment of Frameless Intrafraction Motion
The purpose of this study is to assess the ability of a modified thermoplastic mask system in keeping an individual head stationary for a predefined amount of time.
- Trial name
- NCT01202539
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Brain Metastases
University of Kentucky Markey Cancer Center Neuro-Oncology Multi-Disciplinary Tumor Board Protocol for the Treatment of Advanced Brain Metastases
This study evaluates whether review by the University of Kentucky Markey Cancer Center Neuro-Oncology Multidisciplinary Tumor Board improves clinical outcomes for adults with advanced brain metastases.
- Trial name
- NCT07786311
- Testing
- Neuro-Oncology Multi-Disciplinary Tumor Board Review
- Volunteers
- 125 people
- Sponsor
- John L. Villano, MD, PhD
Fatigue, Cancer
Exercise for Young Adults With Cancer
Over the past decade, importance of supportive care in cancer treatment of young cancer patients has increased. However, most common cancer-related side effects, such as physical deconditioning, psychological problems…
- Conditions
- Fatigue, Cancer, Physical Activity, Exercise
- Trial name
- YOUEX (NCT05613699)
- Testing
- Exercise - Social Media, Exercise - App, Exercise - closed to patients residence
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- University Hospital Heidelberg
Neoplasm Metastasis
Dexamethasone for Palliation - Brain Metastases
Brain metastases occur when cancer cells from the initial tumour site (for example, lung or breast) spread to the brain. This develops in approximately 10% - 30% of adults with cancer.
- Trial name
- NCT00188864
- Testing
- dexamethasone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Brain and Central Nervous System Tumors, Unspecified Childhood Solid Tumor, Protocol Specific
Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as temozolomide, vincristine, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00138216
- Testing
- irinotecan hydrochloride, temozolomide, vincristine sulfate
- Where
- 18 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- Children's Oncology Group
Surgery, Pituitary Adenoma
Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
The surgical treatment strategy for giant invasive pituitary adenoma is one of the current hot spots in the field of clinical research on pituitary adenoma.
- Trial name
- NCT05448690
- Testing
- Two different approaches, Non-combined approach
- Where
- 13 sites in China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital
Locally Advanced Adrenal Gland Pheochromocytoma, Locally Advanced Paraganglioma
Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers
This phase II trial studies how well 177Lu-DOTATATE works in treating patients with rare endocrine cancers that have spread from where they started to nearby tissue or lymph nodes (locally advanced), spread to other places in the…
- Conditions
- Locally Advanced Adrenal Gland Pheochromocytoma, Locally Advanced Paraganglioma, Metastatic Adrenal Gland Pheochromocytoma, Metastatic Paraganglioma
- Trial name
- NCT04106843
- Testing
- Lutetium Lu 177 Dotatate
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Recurrent Diffuse Intrinsic Pontine Glioma
Hypofractionated Radiotherapy for Recurrent DIPG
This study evaluates the feasibility of hypofractionated radiotherapy (RT) in the palliative treatment of recurrent diffuse intrinsic pontine glioma (DIPG).
- Trial name
- NCT03841435
- Testing
- Hypofractionated Radiotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Cincinnati
Tumors Metastatic to Brain
Sorafenib Tosylate and Stereotactic Radiosurgery in Treating Patients With Brain Metastases
RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.
- Trial name
- NCT01276210
- Testing
- sorafenib tosylate, stereotactic radiosurgery, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Glioblastoma, Brain Tumor
Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma
Patients may participate in this research study if they have glioblastoma. (a brain tumor) that has come back after being treated. Standard treatment for this cancer is a chemotherapy drug called bevacizumab.
- Trial name
- NCT02768389
- Testing
- Bevacizumab, Modified Atkins Diet
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Tumors Metastatic to Brain, Unspecified Adult Solid Tumor
Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases
This phase I/II trial studies the side effects and the best dose of stereotactic radiosurgery and to see how well it works in treating patients with large brain metastases.
- Trial name
- NCT01843413
- Testing
- stereotactic radiosurgery, quality-of-life assessment, cognitive assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Case Comprehensive Cancer Center
Leukemia, Lymphoma
Cognitive Training in Attenuating Attention Deficits/Child Treatment for Cancer
Primary Objectives: 1. To evaluate the feasibility of enrolling children and adolescents with newly diagnosed brain tumors, leukemia, or lymphoma in a program designed to prevent the academic and cognitive declines that commonly…
- Conditions
- Leukemia, Lymphoma, Brain Tumor
- Trial name
- NCT00498719
- Testing
- Cognitive Training Program, Control Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
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