Clinical trials: for Brain Tumors
Non-small Cell Lung Cancer
Asymptomatic Brain Metastasis in Non-small Cell Lung Cancer (NSCLC)
The prognosis of NSCLC patients with asymptomatic brain metastasis, who are not treated with SRS or WBRT has not been fully investigated yet.
- Trial name
- NCT01130766
- Testing
- stereotactic radiosurgery (SRS)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Samsung Medical Center
Brain Cancer, Glioblastoma Multiforme
Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)
Phase I Objectives: -To determine the maximum tolerated dose (MTD) of vorinostat + erlotinib versus vorinostat + erlotinib + temozolomide in adult patients with recurrent glioblastoma multiforme (GBM) and anaplastic gliomas.
- Trial name
- NCT01110876
- Testing
- Vorinostat, Erlotinib, Temozolomide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Non Small Cell Lung Cancer
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases
20-40% of patients with NSCLC will develop brain metastases at some point during their course of disease. Osimertinib has demonstrated intracranial activity in EFGR mutated NSCLC with leptomeningeal disease in the phase 1 BLOOM…
- Trial name
- OUTRUN (NCT03497767)
- Testing
- Osimertinib, Stereotactic Radiosurgery (SRS)
- Where
- 13 sites in Australia, Singapore
- Volunteers
- 40 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Primary Brain Tumor, PBT
CBT for Insomnia in Primary Brain Tumor Patients
The purpose of this study is to pilot test an empirically supported psychotherapeutic intervention, Cognitive Behavior Therapy for Insomnia (CBT-I) in primary brain tumor patients.
- Trial name
- NCT04919993
- Testing
- Cognitive Behavioral Therapy-Insomnia
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University
Brain Tumor
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor.
- Trial name
- NCT04692337
- Testing
- Intra-operative Ommaya Reservoir placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Spinal Cord Cancer, Brain (Nervous System) Cancers
Cyberknife Precision Radiation Delivery System for Tumors of the Spine
The purpose of this study is to determine the usefulness of Cyberknife precision radiation in eliminating or preventing the further growth of spinal tumors and lesions.
- Trial name
- NCT00185666
- Testing
- Stereotactic radiosurgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Brain Metastases
Automated Detection of Brain Metastases on MRI
This reader study aims at assessing whether the radiologist aided with AI software has at least a non-inferior performance than without AI assistance in detecting brain metastases.
- Trial name
- BrainMets AI (NCT06727032)
- Testing
- Brain Metastasis AI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Robovision BV
Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain
7T MRI Scan for the Early Detection of Melanoma Brain Metastases
This clinical trial studies the use of 7-Tesla (7T) magnetic resonance imaging (MRI) in detecting melanoma that has spread to the brain (melanoma brain metastases).
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Trial name
- NCT04941430
- Testing
- Magnetic Resonance Imaging using 7 Tesla MRI
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Southern California
Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor
High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor, Testicular Germ Cell Tumor
- Trial name
- NCT01172912
- Testing
- filgrastim, pegfilgrastim, carboplatin
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Malignant Glioma (WHO Grade III or IV)
Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure
The primary objectives of the study are to determine the maximum tolerated dose (MTD) of Carboxyamidotriazole Orotate (CTO) when combined with standard dosing of bevacizumab among patients with recurrent malignant glioma (WHO…
- Trial name
- NCT01954030
- Testing
- CTO and Bevacizumab, CTO alone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Annick Desjardins
Brain Neoplasms
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery
Vitamin D supplementation not only has beneficial effects on morbidity and mortality in critically ill patients but it may also lead to alleviate of seizure, brain edema, infection, pain and some other perioperative…
- Trial name
- NCT03248544
- Testing
- vitamin D, control
- Where
- 2 sites in Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University
Dementia, Mild
Effects of An ACP Programme for Older People With Early Dementia
Advance care planning (ACP) has been widely advocated for persons with early stage dementia (PWEDs). This proposed study attempts to promote the uptake of ACP for this population and their family caregivers in the community and…
- Trial name
- NCT05240664
- Testing
- Have A Say Programme, Attention-control health talks
- Where
- 6 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hong Kong Metropolitan University
Non-Small Cell Lung Cancer, Brain Metastasis
Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer
This is a non-randomized open-label uncontrolled phase II trial evaluating efficacy and toxicity of gefitinib in patients with asymptomatic advanced NSCLC who was benefitted by first line chemotherapy.
- Trial name
- NCT00614809
- Testing
- gefitinib
- Volunteers
- 45 people
- Sponsor
- Guangdong Provincial People's Hospital
Glioblastoma, Malignant Glioma
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma
This phase I trial tests the safety, side effects, and best dose of dexamethasone when given with azeliragon in managing cerebral edema after surgery (post-resection) in patients with glioblastoma.
- Trial name
- NCT05773664
- Testing
- Azeliragon, Biospecimen Collection, Computed Tomography
- Sponsor
- City of Hope Medical Center
Brain and Central Nervous System Tumors
Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma
RATIONALE: In this study a combination of anti-cancer drugs (chemotherapy) is used to treat brain tumors in young children. Using chemotherapy gives the brain more time to develop before radiation is given.
- Trial name
- NCT00602667
- Testing
- Induction Chemotherapy, Low-Risk Therapy, High-Risk Therapy
- Where
- 6 sites in United States, Australia
- Volunteers
- 293 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Metastases, Growing Lesions After Radiosurgical Treatment
Non Invasive Methods for Differential Diagnosis Radionecrosis/Recurrence After Radiosurgery of Brain Metastases
The purpose of this multicenter study is to assess a diagnostic strategy concerning differential diagnosis between radiation necrosis and relapse in brain metastases treated with radiosurgery.
- Trial name
- CV-METANEC (NCT02636634)
- Testing
- imaging
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Metastases, Adult, Stereotactic Radiotherapy
a Feasibility Study of iHD-SRT for BM
Brain metastasis is the most challenging disease in the field of tumor treatment, with a median overall survival of only 1-2 months for untreated patients.
- Trial name
- NCT06231186
- Testing
- iHD-SRT
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Ruijin Hospital
CDK Gene Mutation, Metastatic Malignant Neoplasm in the Brain
Genetic Testing in Guiding Treatment for Patients With Brain Metastases
This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain.
- Conditions
- CDK Gene Mutation, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, NTRK Family Gene Mutation
- Trial name
- NCT03994796
- Testing
- Abemaciclib, PI3K Inhibitor paxalisib, Entrectinib
- Where
- 435 sites in United States
- Volunteers
- 50 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Metastatic Malignant Neoplasm in the Brain, Radiation Therapy Recipient
nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex
This trial studies how well nTMS works in planning for stereotactic radiosurgery in patients with brain metastases in the motor cortex.
- Trial name
- NCT04062305
- Testing
- Hand Function Test, Navigated Transcranial Magnetic Stimulation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Recurrent Glioblastoma
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)
The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of…
- Trial name
- OptimalTTF-2 (NCT04223999)
- Testing
- Skullremodeling surgery, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Anders Rosendal Korshøj
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