Clinical trials: for Substance Abuse Treatment
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
This is a sub-study of NIDA CTN Protocol 0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs; Unique protocol ID: 2019-0429-1).
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs-INO (NCT03911739)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- T. John Winhusen, PhD
Cannabis Use Disorder
Cannabidiol (CBD) for the Management of Cannabis Withdrawal: A Phase II Proof of Concept Study
Single subject repeated measures design of an open label administration of Cannabidiol (CBD) to 5 participants withdrawing from cannabis use in an inpatient setting.
- Trial name
- NCT02083874
- Testing
- CBD
- Volunteers
- 5 people
- Sponsor
- The University of New South Wales
Heroin Dependence, Opiate Dependence
Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction
The planned research will adapt an intervention of known efficacy to target a new outcome of significant importance to public health.
- Conditions
- Heroin Dependence, Opiate Dependence, Substance Dependence
- Trial name
- NCT00609089
- Testing
- CRAFT-T, Treatment as usual
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Insomnia, Depressive Disorder, Major
Cannabinoids as a Treatment for Insomnia in Major Depression
This single-site study is a pilot, three-armed, double-blinded, placebo-controlled randomized controlled trial (RCT) that will determine the feasibility of a definitive RCT investigating the use of cannabis oil as a treatment for…
- Conditions
- Insomnia, Depressive Disorder, Major, Sleep Disorder, Depression
- Trial name
- CANMDD (NCT05041647)
- Testing
- 25:1 CBD/THC, 5:1 CBD/THC
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Substance Abuse, Sleep Disturbances
Exploring Substance Use, Sleep Disturbances and Reward Sensitivity
According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve…
- Trial name
- NCT07028346
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Volunteers
- 154 people
- Sponsor
- Kwai Chung Hospital
Methamphetamine Addiction
A Pilot Trial of Dextroamphetamine for Methamphetamine Dependence
The purpose of this study is to assess the safety and effectiveness dextroamphetamine to help methamphetamine users quit or cut down on their use. The study lasts for 9 weeks.
- Trial name
- 1D (NCT00630682)
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- California Pacific Medical Center Research Institute
Cannabis Intoxication
Pregnenolone as a Treatment for Cannabis Intoxication
The present study will characterize the ability of pregnenolone to reverse the acute intoxication and associated symptoms of cannabis.
- Trial name
- NCT07216690
- Testing
- Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opiate Addiction
Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
This study is designed to determine the relative effectiveness of buprenorphine/naloxone (Suboxone) pharmacotherapy versus naltrexone pharmacotherapy for treatment retention, relapse prevention and opioid craving reduction among…
- Trial name
- NCT01015066
- Testing
- Buprenorphine/naloxone, Naltrexone
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Alcohol Use Disorder
Towards a Targeted Ultrasound Neuromodulation Intervention for Alcohol Abuse Disorders
This study explores the potential of transcranial ultrasound stimulation (TUS) as an innovative therapeutic approach for individuals with Alcohol Use Disorder.
- Trial name
- TUS-AUD (NCT06894966)
- Testing
- low intensity transcranial focused ultrasound stimulation (TUS)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Plymouth
Methamphetamine Dependence, Substance Abuse
RTI-336 as a Treatment for Methamphetamine Dependence
The purpose of this study is to evaluate the safety and efficacy of RTI-336 as a treatment for methamphetamine (METH) dependence in non-treatment-seeking METH-dependent volunteers.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT01601717
- Testing
- RTI-336
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders, Opioid-Related Disorders
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect.
- Trial name
- NCT00218608
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hidradenitis Suppurativa
Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), is a chronic skin disease, manifested as inflamed areas of hair follicles around apocrine sweat glands found in areas most commonly the axillae, inguinal and anogenital regions.
- Trial name
- NCT03929835
- Testing
- Cannabis oil
- Where
- Israel
- Sponsor
- TO Pharmaceuticals
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Alcohol-related Disorders, Alcohol Drinking
Medication and Counseling for Controlled Drinking (Project SMART)
The purpose of this study is to study the effectiveness of medication and specialized psychotherapy in helping gay and bisexual men who do not want to quit drinking learn how to reduce their drinking to healthier levels.
- Conditions
- Alcohol-related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
- Trial name
- NCT00444418
- Testing
- Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse or Dependence
Web-based CBT4CBT for Alcohol
The investigators are conducting a randomized clinical trial of our new web-based version of the CBT4CBT (Computer Based Training for Cognitive Behavioral Therapy) program specifically designed for alcohol to evaluate its…
- Trial name
- CBT4CBT Etoh (NCT01615497)
- Testing
- Standard Treatment as Usual (TAU), Web-based CBT4CBT for alcohol plus TAU, Web-based CBT with minimal clinical contact
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol Dependence
Tech-Enabled CM for AUD at Scale
This Phase II Small Business Innovative Research (SBIR) project is a clinical effectiveness and cost-effectiveness random controlled trial (RCT) of DynamiCare Health's innovative smartphone/smart debit card remote digital…
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Drug Dependence
- Trial name
- NCT04581499
- Testing
- DynamiCare Motivation Support Program, Untreated or Routine Care Control Group
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- DynamiCare Health
Maternal Substance Use, Child Abuse and Neglect
Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
The primary goal of this Stage I therapy development study will be to manualize and test the preliminary efficacy of a parenting intervention for drug dependent mothers that aims to foster their ability to recognize children's…
- Trial name
- NCT00319436
- Testing
- Mentalizing Therapy for Substance Using Mothers, Standard Parent Education for Substance Using Mothers
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Marijuana Dependence
Vilazodone Treatment for Marijuana Dependence
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence.
- Trial name
- NCT01574183
- Testing
- Vilazodone
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Alcohol Dependence, Alcohol Interaction
Clinical Trial to Evaluate the Safety of PT150 (Formerly ORG34517) When it is Taken Concurrently With Alcohol
The purpose of the clinical study is to compare pharmacodynamic and safety endpoints following an alcohol challenge prior to and concurrent with PT150 (study drug) treatment.
- Trial name
- NCT03548714
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pop Test Oncology LLC