Clinical trials: in Situ Breast Cancer
Breast Cancer, Invasive Breast Cancer
BrUOG 351: PRE-OPERATIVE APBI USING NIBB
Partial breast irradiation is typically performed after surgical removal of the tumor. Partial breast irradiation allows for focused radiation to the area from which the cancer was removed, sparing breast tissue from the…
- Conditions
- Breast Cancer, Invasive Breast Cancer, Ductal Carcinoma in Situ
- Trial name
- 351 (NCT03437915)
- Testing
- NIBB: accuboost, Partial mastectomy
- Sponsor
- Jaroslaw Hepel
Breast Cancer, Ductal Carcinoma in Situ
Effect of Pharmacogenomics Differences in Phase I and II Metabolism of Tamoxifen on Efficacy and Toxicity
This study will be an open-label prospective observational trial designed to test associations between polymorphisms of candidate genes and tamoxifen.
- Trial name
- NCT00886535
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Milton S. Hershey Medical Center
Breast Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Partial Breast Radiation Therapy in Treating Women Undergoing Breast Conservation Therapy for Early-Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. PURPOSE: This clinical trial is studying the side effects of partial breast radiation therapy and how well it works in treating women undergoing breast…
- Conditions
- Breast Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Skin Reactions Secondary to Radiation Therapy
- Trial name
- NCT00599989
- Testing
- adjuvant therapy, conventional surgery, 3-dimensional conformal radiation therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia
Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial
This phase II trial evaluates response-guided low-dose tamoxifen for reducing breast density in women who are at higher than average risk for breast cancer.
- Conditions
- Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia, Breast Carcinoma, Breast Ductal Carcinoma In Situ
- Trial name
- NCT06184750
- Testing
- Biopsy Procedure, Biospecimen Collection, Mammography
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Ductal Carcinomas
MRI in Ductal Carcinoma in Situ (DCIS)
Compare the estimate of the lesional size in MRI to that in mammography, taking as a reference the definitive anatomo-pathological size
- Trial name
- NCT03543397
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Strasbourg, France
Invasive Ductal Carcinoma, Ductal Carcinoma In Situ
An Efficacy Study of the Xoft® Axxent® eBx® IORT System® "Lite"
The purpose of this trial is to assess the efficacy of the Xoft Axxent eBx System when used for single-fraction IORT in early stage breast cancer.
- Trial name
- NCT04349111
- Testing
- Intra-operative Radiation Therapy - IORT
- Sponsor
- Xoft, Inc.
BRCA1 Mutation Carrier, BRCA2 Mutation Carrier
Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of soy isoflavones supplements may prevent or treat early stage breast cancer.
- Conditions
- BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ
- Trial name
- NCT01219075
- Testing
- soy isoflavones, questionnaire administration, magnetic resonance imaging
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Breast Cancer, Menopausal Symptoms
Studying Blood Samples From Women With Breast Cancer or Ductal Carcinoma In Situ Who Are Receiving Tamoxifen
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about differences in DNA and predict how well patients will respond to treatment and plan better treatment.
- Trial name
- NRR (NCT00764322)
- Testing
- tamoxifen citrate, gene expression analysis, pharmacogenomic studies
- Where
- 7 sites in United States
- Volunteers
- 501 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Precancerous Condition
Breast Cancer Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer
RATIONALE: Gathering information about patients with breast cancer and their families may help the study of breast cancer in the future.
- Trial name
- BCCR (NCT00666731)
- Testing
- medical chart review, questionnaire administration, study of socioeconomic and demographic variables
- Where
- 65 sites in United States
- Volunteers
- 4,945 people
- Sponsor
- University of Nebraska
Ductal Carcinoma in Situ
A Pilot Pre-operative Window Trial of Black Cohosh in Women With Ductal Carcinoma in Situ
The investigators hypothesize that black cohosh, as a potentially therapeutic agent, will reduce the overall size and aggressiveness of ductal carcinoma in situ (DCIS) when given in a pre-operative setting.
- Trial name
- NCT01628536
- Testing
- Black cohosh
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Ductal Carcinoma in Situ
A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ
The purpose of this study is to find molecular signs (biomarkers) to better understand the role of green tea as an anti-cancer and anti-inflammation agent in women with newly-diagnosed ductal carcinoma in situ (DCIS).
- Trial name
- NCT01060345
- Testing
- Polyphenon E
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Breast Cancer
Tamoxifen Compared With LY353381 in Treating Women With Newly Diagnosed Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen or LY353381 may fight breast cancer by blocking the use of estrogen.
- Trial name
- NCT00005886
- Testing
- arzoxifene hydrochloride, tamoxifen citrate
- Where
- 9 sites in United States
- Sponsor
- University of Kansas Medical Center
DCIS, Breast Cancer
Radiotherapy Omission in Low Risk Ductal in Situ Carcinoma Breast
Following breast-conserving surgery (BCS) for localized ductal carcinoma in situ (DCIS) of the breast, whole-breast irradiation (WBRT) is a standard of care, reducing the absolute rate of in-breast recurrences (IBR) by more than…
- Conditions
- DCIS, Breast Cancer, Low Risk DCIS, Breast Conserving Surgery
- Trial name
- ROMANCE (NCT03878342)
- Testing
- Radiotherapy, No Radiotherapy
- Where
- 37 sites in France
- Volunteers
- 295 people
- Sponsor
- UNICANCER
Breast Cancer
Biomarkers in Tissue Samples From Patients With Ductal Breast Carcinoma in Situ
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01132560
- Testing
- RNA analysis, gene expression analysis, reverse transcriptase-polymerase chain reaction
- Volunteers
- 500 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Breast Cancer, Invasive Breast Cancer
Prospective Breast Cancer Biospecimen Collection
Tissue will be procured during a standard of care procedure the patient will already be scheduled to undergo. A one time blood draw will be performed at this time and an optional rectal swab for biome analysis may occur.
- Conditions
- Breast Cancer, Invasive Breast Cancer, Carcinoma in Situ of the Breast
- Trial name
- NCT04074720
- Testing
- Tissue Sample collection, Blood Sample Collection, Rectal Swab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Breast Cancer
Molecular Breast Imaging (MBI) in Patients With Suspected Ductal Carcinoma in Situ (DCIS)
In this research study, the investigators are testing a new type of breast camera, called Molecular Breast Imaging, to see if it can find tumors in the subject's breast.
- Trial name
- NCT00890994
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Breast Neoplasms, Carcinoma, Ductal
Spect Analysis of Cardiac Perfusion Changes After Whole Breast/Chest Wall Radiation Therapy With ABC
Cardiac perfusion changes have been seen after whole breast / chest wall irradiation for breast cancer. The Active Breathing Coordinator (ABC) device theoretically decreases radiation exposure to the heart during radiation for…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Adenocarcinoma
- Trial name
- NCT00321048
- Testing
- Active Breathing Coordinator
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
DCIS, Stage 0 Breast Cancer
The PREDICT Registry:
This is a prospective, non-interventional (observational) cohort study conducted within the medical network of the participating investigators and institutions.
- Conditions
- DCIS, Stage 0 Breast Cancer, Ductal Breast Carcinoma In Situ
- Trial name
- NCT03448926
- Testing
- Treatment recommendation surveys, 7-gene biosignature
- Where
- 30 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- PreludeDx
Breast Cancer, Cognitive Ability, General
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. Radiation therapy may cause skin reactions when patients are exposed to high-energy x rays.
- Conditions
- Breast Cancer, Cognitive Ability, General, Fatigue, Pain
- Trial name
- NCT01407770
- Testing
- DNA analysis, gene expression analysis, enzyme-linked immunosorbent assay
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Wake Forest University Health Sciences
Stage IA Breast Cancer, Stage IB Breast Cancer
Telephone-Based Intervention in Increasing Adherence to Adjuvant Hormonal Therapy in Patients With Breast Cancer
This pilot trial studies a telephone-based intervention to see if it increases adherence to adjuvant hormonal therapy in patients with breast cancer.
- Conditions
- Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer
- Trial name
- NCT02400060
- Testing
- Telephone-Based Intervention, Survey Administration, Laboratory Biomarker Analysis
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- Ohio State University Comprehensive Cancer Center