Clinical trials: mRNA Expression
Cardiovascular Diseases
The Effects of Fat and Theobromine on apoA-I
Rationale: Despite successful efforts to lower atherogenic serum low-density lipoprotein (LDL) cholesterol concentrations, a substantial residual cardiovascular risk is still present.
- Trial name
- NCT02085109
- Testing
- Fat milkshake, Theobromine
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Men
LDL Receptor Under Ezetimibe and Simvastatin
The purpose of this study is to investigate the effects of the two lipid -lowering drugs, ezetimibe and simvastatin, on lipid metabolism in humans.
- Trial name
- NCT00317993
- Testing
- ezetimibe, simvastatin, ezetimibe plus simvastatin
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Non-small Cell Lung Carcinoma
Genotype-Driven Treatment of Advanced Non-small Cell Lung Cancer Based on mRNA Expression of ERCC1 & RRM1 as First-line Chemotherapy
This is a prospective phase II trial, in patients with unresectable or metastatic NSCLC using chemotherapy regimens which will be defined according to the mRNA expression of ERCC1 and RRM1 of the tumor cells.
- Trial name
- NCT01648517
- Testing
- chemotherapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Non-Squamous Non-Small Cell Lung Cancer
A Genetic Substudy Associated With the Avastin (Bevacizumab) Study MO19390 in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
This single arm genetic substudy of MO19390 will test the hypothesis that there is a positive relationship between mRNA BRCAI levels and the response to different chemotherapy combinations plus Avastin.
- Trial name
- NCT00642824
- Testing
- Standard chemotherapy, bevacizumab [Avastin]
- Where
- 22 sites in Spain
- Volunteers
- 3 people
- Sponsor
- Hoffmann-La Roche
Vitamin D Receptor Defect
Endometrial Vitamin D Receptor in PCOS
Vitamin D receptor (VDR) is widely expressed not only in tissues responsible for calcium hemostasis, but also in reproductive organs, including the endometrium.
- Trial name
- NCT05885633
- Testing
- endometrial sampling with pipelle
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Uşak University
Tumors
Expression of NIS Protein and mRNA in Thyroid Tumors
The uptake of iodide by thyroid cells requires the expression of sodium iodide symporter (NIS). Thyroid benign and malignant tumors have low iodide uptake activity.
- Trial name
- NCT00459498
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Tuberculosis
Multi-Drug Resistant Tuberculosis in Korea
This study, conducted in Korea, will examine why some people are more susceptible to tuberculosis (TB) than others and why some strains of M tuberculosis (the bacteria that causes TB) are more difficult to treat or become…
- Trial name
- NCT00341601
- Where
- 2 sites in South Korea
- Volunteers
- 777 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malignant Melanoma
Vaccination With Tumor mRNA in Metastatic Melanoma - Fixed Combination Versus Individual Selection of Targeted Antigens
The purpose of the vaccination protocol is to induce specific immune responses against melanoma associated antigens by intradermal injections of mRNA coding for the corresponding antigen.
- Trial name
- NCT00204516
- Testing
- mRNA coding for melanoma associated antigens, GM-CSF
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer
Paclitaxel, Doxorubicin, and Cyclophosphamide With Or Without Carboplatin in Treating Women With Locally Advanced Breast Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, doxorubicin, cyclophosphamide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00589238
- Testing
- carboplatin, cyclophosphamide, doxorubicin hydrochloride
- Where
- 2 sites in Singapore
- Volunteers
- 16 people
- Sponsor
- National Cancer Centre, Singapore
COVID-19 Vaccine
Immunogenicity Induced by COVID-19 Vaccines in Mexican Population
To determine the gene expression of anti-spike IgG through PCR-RT in patients vaccinated with the 4 types of vaccines available in Mexico Oxford/AstraZeneca (ChAdOx1 nCoV-19), Centro Nacional Gamaleya (Sputnik V), Pfizer/BioNTech…
- Trial name
- Vaccines COVID (NCT06597370)
- Testing
- Gene expression mRNA of IgG anti-spike
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Helicobacter Pylori Infection
Long-term Follow-up of Interleukin-1B and H+,K+-ATPase mRNA Expression After Helicobacter Pylori Eradication
We will evaluate the long-term changes of gastric H+, K+-adenosine triphosphatase (H+, K+-ATPase) and Interleukin-1B mRNA expression according to Helicobacter pylori (H.pylori) infection and intestinal metaplasia and investigate…
- Trial name
- NCT04037904
- Where
- South Korea
- Volunteers
- 490 people
- Sponsor
- Seoul National University Bundang Hospital
Non-small Cell Lung Cancer
Individualized Chemotherapy Based on BRCA1 and RRM1 mRNA for Advanced Non-small Cell Lung Cancer (NSCLC)
Gemcitabine, docetaxel, CPT-11 and cisplatin are effective in 1st line treatment of advanced non-small cell lung cancer (NSCLC). Platinum-based doublets including gemcitabine, docetaxel or CPT-11 are standard 1st regimens.
- Trial name
- BRAVO (NCT01424709)
- Testing
- Gemcitabine, Docetaxel, CPT-11,Cisplatin, gemcitabine/cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji University
Obesity, Type 2 Diabetes
Changes of Biomarkers in Response to Training and Antioxidant Treatment
The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants.
- Trial name
- NCT00638560
- Testing
- Vitamin C, Vitamin E, Antioxidant treatment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Cervical Prostaglandin EP3 Receptors, Pregnancy
The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors
The purpose of this study is to determine the effect of mifepristone on the expression of three cervical EP3 receptor isoforms (EP3-2, EP3-3 and EP3-6) in pregnant women ≤63 days gestational age.
- Trial name
- EP3 (NCT01224509)
- Testing
- Mifepristone, Non-treatment
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Southern California
Preterm Birth, Premature Rupture of Membranes
Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition
The understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult.
- Trial name
- NCT00342277
- Where
- 4 sites in United States, Chile and 2 more
- Volunteers
- 6,838 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Type2 Diabetes, Healthy Obesity, Metabolically
Influence of Dairy Protein Breakfast on Glycemia, Weight Loss and Clock Genes in T2D
This study in T2D patients is undertaken to evaluate the effect of previously studied 3Meals Diet, high energy breakfast (Bdiet) with milk and dairy proteins (MBdiet) versus isocaloric diet with same meal distribution but with…
- Trial name
- Mdiet (NCT03772067)
- Testing
- Continuous glucose monitoring CGM, Clock Genes m RNA expression, Postprandial Glucose
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Mitochondrial Biogenesis
Examining the Impact of Blood Flow Restricted Aerobic Exercise on PGC-1α mRNA Expression in Young Healthy Males
This crossover study investigates the effects of restricting arterial blood flow during cycling exercise on PGC-1α and its upstream signalling pathways.
- Trial name
- NCT03717948
- Testing
- BFR Exercise, CTL Exercise
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Queen's University
Interstitial Cystitis, Bladder Diseases
Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes…
- Conditions
- Interstitial Cystitis, Bladder Diseases, Urinary Incontinence
- Trial name
- NCT00253006
- Testing
- Tissue examination for protein- and mRNA-expression of NO
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital at Herlev
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine