Clinical trials: malaria
Malaria, Falciparum
Drug-Interaction Assessment of GSK3772701 in Healthy Male and Female Participants Aged 18 to 55 Years
This study aims to evaluate whether GSK3772701 alters the pharmacokinetics (PK) of midazolam (MDZ), a standard probe substrate for the CYP3A4 enzyme.
- Trial name
- NCT07670377
- Testing
- Midazolam (MDZ), GSK3772701
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Mass Drug Administrations of DHA-PQP to Accelerate Towards Malaria Elimination in Magude District, Southern Mozambique
In line with the global and regional efforts towards malaria elimination, a five year program was established to assist the NMCP in adopting targeted evidence-based elimination plans through a 'learn by doing' strategy.
- Trial name
- MDAM (NCT02914145)
- Testing
- Dihydroartemisinin-piperaquine
- Volunteers
- 240,502 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Malaria
A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, Administered With and Without Matrix-M1
This is a clinical trial in which healthy volunteers will be administered one or two experimental malaria vaccines. The vaccine R21 will either be administered alone or in combination with the adjuvant vaccine Matrix-M1.
- Trial name
- NCT02572388
- Testing
- R21, Matrix-M1
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Subjects
Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects
This was a single-center study using induced blood stage malaria infection to characterize the activity of ACT-451840 against early Plasmodium falciparum blood stage infection
- Trial name
- NCT02223871
- Testing
- ACT-451840:, Plasmodium falciparum-infected human erythrocytes:, Artemether 20 mg and lumefantrine 120mg combination tablet:
- Where
- Australia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Malaria
Anti-Malarial Drug Resistance in Cameroon
The project is a three-armed study designed to evaluate the efficacy of amodiaquine(AQ), sulphadoxine-pyrimethamine(SP) and(AQ+SP) in three sites in Cameroon that differ in their baseline characteristics for malaria.
- Trial name
- NCT00146718
- Testing
- Amodiaquine and Sulphadoxine/Pyrimethamine
- Volunteers
- 755 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Covid19, Paludism
Malaria as a Protection Factor Against Severe COVID-19 (Known as SARS-COV-2) in the Democratic Republic of Congo (Palu-COVID)
In this study, the investigators will explore the reasons for the apparently lower proportion of severe COVID-19 cases in many sub-Sahara African countries.
- Trial name
- Palu-COVID (NCT05012280)
- Where
- Democratic Republic of the Congo
- Volunteers
- 238 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria, Vivax Malaria
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
To determine whether two cheap antifolates (chlorproguanil-dapsone and sulfadoxine-pyrimethamine) which work against falciparum malaria in this region are sufficiently effective against vivax malaria to be deployed in areas where…
- Trial name
- NCT00158561
- Testing
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone
- Where
- Pakistan
- Volunteers
- 750 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Anemia
Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery
Based in part on the pivotal studies conducted in Mali, SMC was approved by WHO as a policy for malaria control in countries with seasonal malaria transmission such as Mali in March 2012.
- Trial name
- SMC (NCT02646410)
- Testing
- FPD+NDOT, FPD+DOT, DDD+NDOT
- Where
- Mali
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Malaria
Impact of Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lampung Province, Sumatra
Artemisinin-based combination therapy (ACT) has been known to be controversial for stopping malaria transmission. The addition of primaquine (PQ) - the only drug commercially available that kills mature transmission stage - to…
- Trial name
- NCT01389557
- Testing
- Dihydroartemisinin-piperaquine with primaquine
- Where
- Indonesia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Malaria, Effectiveness
Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria
Objective: to measure the effectiveness and safety of (artemether-lumefantrine) AL and (dihydroartemisinin-piperaquine) DP in patients (> 6 months) suffering from uncomplicated P. falciparum malaria.
- Trial name
- NCT04897919
- Testing
- Dihydroartemisinin-piperaquine 160 mg/20 mg Oral Tablet, Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
- Where
- Guinea-Bissau
- Volunteers
- 474 people
- Sponsor
- Bandim Health Project
Plasmodium Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost-effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05117567
- Testing
- Personal protection package
- Volunteers
- 5,868 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Arbovirus Infections
The Interest of Systematic Screening for Dengue, Chikungunya, and Zika, in Malaria-negative Return Travelers
International travel has increased dramatically in recent years. Vector-borne pathologies such as malaria and arboviruses are common etiologies of post-travel fever, which are prevalent in similar geographical areas (tropical and…
- Trial name
- NCT06651372
- Testing
- The retrospective analyses planned for these samples consist of serological analysis and molecular analysis (RT-PCR ) according to the date of symptoms ons
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Malaria, Hiv
OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa
A longitudinal study with four parallel cohorts with each participant followed for 2 years: two cohorts in Busia (high malaria transmission site) and two cohorts in Kampala (low malaria transmission).
- Trial name
- OPTIMAH (NCT06967519)
- Testing
- Artemether-lumefantrine (AL), artesunate-amodiaquine (AS-AQ)
- Where
- 2 sites in Uganda
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Yale University
Malaria
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria
The purpose of this study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (Pyramax®, PA) (180:60 mg) with that of standard chloroquine therapy in children and adults with acute…
- Trial name
- NCT00440999
- Testing
- Pyronaridine artesunate, Chloroquine
- Where
- 5 sites in Cambodia, India and 2 more
- Volunteers
- 456 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Disease, Infectious
Perceptions, Representations and Experiences of Malaria Prophylaxis in Patients Born in Endemic Areas and Living in France.
The aim of this study is to analyze the perceptions, representations and expe-riences of malaria prophylaxis in patients born in endemic areas and living in France.
- Conditions
- Malaria, Disease, Infectious, Travel-Associated Infections
- Trial name
- PREPAP (NCT04494854)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Plasmodium Falciparum Malaria
AMA1-C1/Alhydrogel + CpG 7909 for Malaria
The purpose of this study is to test an experimental malaria vaccine in about 75 healthy adults, 18-45 years of age. The study will also test an experimental adjuvant which is a material added to a vaccine to help the body make…
- Trial name
- NCT00344539
- Testing
- AMA1-C1/Alhydrogel®, CPG 7909 Oligodeoxynucleotide (VaxImmune®)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated Plasmodium Falciparum Malaria
A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines
The goal of this open-label randomised, controlled, non-inferiority trial is to assess and compare the efficacy, tolerability and safety of a fixed dose TACT artemether-lumefantrine-amodiaquine (ALAQ) to the ACTs…
- Trial name
- FD-TACT (NCT05951595)
- Testing
- Artemether-Lumefantrine-Amodiaquine (ALAQ), Artemether-Lumefantrine (AL), Artesunate-Amodiaquine (ASAQ)
- Where
- Rwanda
- Volunteers
- 1,680 people
- Sponsor
- University of Oxford
Vivax Malaria
Study on the Treatment of Vivax Malaria
This is a randomised open label trial with follow up for 1 year. 660 adults and children above 6 months diagnosed with acute Plasmodium vivax will be randomised into 3 groups, either chloroquine, artesunate, or…
- Trial name
- VHX (NCT01074905)
- Testing
- Artesunate, Chloroquine, Chloroquine/Primaquine
- Where
- Thailand
- Volunteers
- 655 people
- Sponsor
- University of Oxford
Malaria
Adherence to Antimalarial Drugs in Sierra Leone
The aim of this study is to address this gap in knowledge by measuring the level of patient adherence to co-formulated amodiaquine and artesunate (AQ-AS) compared to artemether-lumefantrine (AL) under routine conditions in Sierra…
- Trial name
- NCT01967472
- Testing
- amodiaquine-artesunate (AQAS) fixed-dose, Artemether-lumefantrine combination (AL) dispersable
- Where
- 2 sites in Sierra Leone
- Volunteers
- 1,145 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diarrhoea, Malaria
Can Mass Media Campaigns Reduce Child Mortality
A cluster-randomised trial will be undertaken in Burkina Faso to investigate whether a comprehensive mass media campaign using local radio stations can change behaviours on a scale large enough to result in measurable and…
- Conditions
- Diarrhoea, Malaria, Pneumonia, Breastfeeding
- Trial name
- NCT01517230
- Testing
- Local radio campaign to reduce under-five child mortality
- Where
- Burkina Faso
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
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