Clinical trials: malaria
Malaria Diagnosis
Vanderbilt-Zambia Innovations in Global Health Technologies
Investigators will evaluate approaches using magnetic bead capture, isolation, and surface tension valve transfer of biomarkers to process capillary blood in order to improve the sensitivity of already approved Rapid Diagnostic…
- Trial name
- VZNIGHT (NCT02700269)
- Testing
- mBEADS
- Where
- Zambia
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Macha Research Trust, Zambia
Malaria (Uncomplicated)
Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria
This is an ongoing monitoring activity of efficacy of sulfadoxine-pyrimethamine (SP), which is the current national treatment of choice for uncomplicated malaria in Tanzania, and a combination of SP and artesunate among children…
- Trial name
- NCT00140361
- Testing
- Sulfadoxine-pyrimethamine, sulfadoxine-pyrimethamine plus artesunate, lumefantrine plus artemether
- Where
- 3 sites in Tanzania
- Volunteers
- 390 people
- Sponsor
- Centers for Disease Control and Prevention
Iron Deficiency Anemia, Iron-deficiency
Optimizing Benefits While Reducing Risks of Iron in Malaria-endemic Areas
Daily iron (ferrous sulfate, 2 mg/kg/day) or placebo syrup for first four months (112 days) of the 12-month (336-day) study. Children in the immediate iron group will receive iron syrup for the first three months (84 days) and…
- Conditions
- Iron Deficiency Anemia, Iron-deficiency, Anemia, Iron Deficiency, Anemia
- Trial name
- OptiM (NCT03897673)
- Testing
- Early Iron, Delayed Iron
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Malaria, Falciparum, Hookworm Infections
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Conditions
- Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium
- Trial name
- NCT01163877
- Testing
- Fe-57 orally, Fe-58 intravenously
- Where
- Côte d’Ivoire
- Volunteers
- 43 people
- Sponsor
- Swiss Federal Institute of Technology
Malaria
Exposure of Naive and Pre-immune Subjects to P. Vivax Challenge
This study is a randomized clinical trial designed to compare the susceptibility of naive and pre-immune volunteers to infectious challenge with viable Plasmodium vivax sporozoites.
- Trial name
- ChallengeIII (NCT01585077)
- Testing
- P. vivax infected mosquito bites
- Where
- Colombia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Socrates Herrera Valencia
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Uncomplicated Plasmodium Falciparum Malaria
Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria
This is Cohort A1 of the Platform study (NCT05750628) to evaluate the efficacy and safety of INE963 in participants with uncomplicated Plasmodium falciparum malaria.
- Trial name
- PLATINUM (NCT07235020)
- Testing
- INE963
- Where
- 6 sites in Burkina Faso, Côte d’Ivoire and 4 more
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
Malaria Active Epidemiology and Treatment Study
An observational cohort and malaria treatment study in Cambodia.
- Trial name
- NCT01280162
- Testing
- Dihydroartemisinin piperaquine
- Where
- Cambodia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Malaria in Pregnancy, Pregnancy Related
MiMBa Pregnancy Registry
The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester.
- Conditions
- Malaria in Pregnancy, Pregnancy Related, Congenital Anomaly
- Trial name
- NCT04825782
- Where
- 2 sites in Burkina Faso, Kenya
- Volunteers
- 15,391 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria, Malaria in Pregnancy
Assessing the Impact of Group Antenatal Care on IPTp Uptake in Tanzania
Group antenatal care (GANC) is a service delivery model where women with pregnancies of similar gestational age are brought together for antenatal care (ANC), incorporating information sharing and peer support.
- Trial name
- GANC-TZ (NCT04148690)
- Testing
- Group antenatal care (GANC), Standard antenatal care
- Where
- Tanzania
- Volunteers
- 4,515 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Chemoprophylaxis
Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania
Background: Malaria prevalence has declined globally following the scale-up of the interventions, including insecticide-treated bed-net, indoor residual spraying, and prompt diagnosis and treatment with artemisinin-based…
- Conditions
- Malaria, Chemoprophylaxis, Underfive Children
- Trial name
- SMC-DP (NCT05874869)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- Tanzania
- Volunteers
- 13,800 people
- Sponsor
- Richard Mwaiswelo
Prophylactic Activity Against Malaria
Prophylactic Antimalarial Activity of DB289 in Volunteers
To evaluate the prophylactic activity of orally administered DB289 against Plasmodium falciparum in non-immune healthy volunteers who are challenged by the bite of five P. falciparum-infected Anopheles stephensi mosquitoes
- Trial name
- NCT00408369
- Testing
- DB289
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Immtech Pharmaceuticals, Inc
Malaria
Trial to Compare Effectiveness of 2 Insecticides in Preventing Malaria
Twenty-four (24) clusters, each containing between 250-300 houses were selected throughout Bioko Island to be sprayed with either a long lasting pyrethroid insecticide, K-Othrine SC 62.5, or a bendiocarb insecticide, FICAM.
- Trial name
- NCT02458066
- Testing
- IRS: bendiocarb, IRS: deltamethrin
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Medical Care Development, Inc.
Malaria, Bacteremia
Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria
While World Health Organization (WHO) guidelines recommend empirical antibacterial therapy as the standard of care in all African children with severe falciparum malaria, there are fewer data to guide the management of adults…
- Conditions
- Malaria, Bacteremia, Sepsis
- Trial name
- ANTHEM (NCT03224052)
- Where
- Burma
- Volunteers
- 20 people
- Sponsor
- Menzies School of Health Research
Malaria, Falciparum
Methylene Blue Against Falciparum Malaria in Burkina Faso
Safety of artesunate-amodiaquine combined with methylene blue or primaquine for falciparum malaria treatment in African children: A randomised controlled trial Elimination has become the goal of malaria programmes in an…
- Trial name
- BlueACTn (NCT02851108)
- Testing
- Methylene Blue, Primaquine
- Where
- Burkina Faso
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Malaria,Falciparum, Parasitemia
Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
This is a single-centre, open-label, Phase Ib study designed to assess if intravenous injection of approximately 3200 P. falciparum (NF54 strain) sporozoites can be safely administered to achieve blood-stage parasitaemia with a…
- Conditions
- Malaria,Falciparum, Parasitemia, Protozoan Infections, Parasitic Disease
- Trial name
- NCT04310085
- Testing
- Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet, PfSPZ-DVI Challenge
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria, Pneumonia
A Comparison of Diagnostic Approaches for Malaria and Pneumonia
This research investigates the diagnostic accuracy of various diagnostic approaches for malaria and pneumonia in under-five children presenting to primary healthcare centres in Benin City, Nigeria.
- Trial name
- NCT02482116
- Testing
- malaria or pneumonia diagnosis
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- University of Nottingham
HIV, Pregnancy Malaria
A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV
More than 3 billion people worldwide are at risk of acquiring malaria and pregnant women living with HIV in Africa are at particular risk.
- Conditions
- HIV, Pregnancy Malaria, Sexually Transmitted Infection
- Trial name
- PREMISE (NCT03431168)
- Testing
- Azithromycin/TMPS
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Alabama at Birmingham
Malaria, Falciparum
Perennial Malaria Chemoprevention in the Malaria Vaccine Era
Malaria remains a major cause of pediatric deaths and morbidity in Africa. An affordable malaria vaccine, R21, is being deployed in Uganda and other African countries with high malaria transmission, but efficacy is incomplete and…
- Trial name
- PMC-VAC (NCT07322068)
- Testing
- Sulfadoxine pyrimethamine + Amodiaquine, Dihydroartemisinin Piperaquine
- Where
- Uganda
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Stanford University
Malaria (Plasmodium Falciparum), Malaria Incidence
Insecticide-Treated Baby Wraps for the Prevention of Malaria
The objective is to test the protective effect of permethrin-treated and etofenprox-treated lesus against malaria in young children
- Trial name
- NCT07773350
- Testing
- Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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