Clinical trials: malaria
Vaccination
Testing a Biometric Identification System to Improve Malaria Vaccine Completion
Receiving all four doses of the malaria vaccine can significantly protect children against malaria illness, hospitalization, and death. However, in Ghana, only 46% of children complete the full vaccination sequence.
- Trial name
- NCT07261280
- Testing
- HEALTH FACILITY INTERVENTION, INDIVIDUAL INTERVENTION
- Where
- Ghana
- Volunteers
- 4,715 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Malaria
Susceptibility of Gambian Adults to PfSPZ-Challenge Infection in the Controlled Human Malaria Infection Model
Controlled human malaria infection (CHMI) is an important tool for the assessment of the efficacy of novel malaria vaccines and drugs prior to field trials.
- Trial name
- CHMI-Gambia1 (NCT03496454)
- Testing
- PfSPZ Challenge
- Where
- The Gambia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Safety, Tolerability and Immunogenicity of PfSPZ Vaccine in an Age De-escalation Trial in Equatorial Guinea.
This trial will evaluate the safety, tolerability, and immunogenicity of PfSPZ Vaccine in healthy Equatoguinean adults, adolescents, children and infants who receive doses of 0.9x10^6, 1.8x10^6 or 2.7x10^6 PfSPZ Vaccine via…
- Trial name
- NCT02859350
- Testing
- PfSPZ Vaccine, PfSPZ Challenge (for CHMI), Normal Saline
- Where
- Equatorial Guinea
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria
Malaria Active Epidemiology and Treatment Study
An observational cohort and malaria treatment study in Cambodia.
- Trial name
- NCT01280162
- Testing
- Dihydroartemisinin piperaquine
- Where
- Cambodia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Vivax Malaria
A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
The goal of this clinical trial is to assess the efficacy and safety or a revised weight band tafenoquine dose in vivax malaria patients.
- Trial name
- TADORE (NCT06148792)
- Testing
- Tafenoquine, Primaquine
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,090 people
- Sponsor
- Menzies School of Health Research
Malaria, Effectiveness
Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria
Objective: to measure the effectiveness and safety of (artemether-lumefantrine) AL and (dihydroartemisinin-piperaquine) DP in patients (> 6 months) suffering from uncomplicated P. falciparum malaria.
- Trial name
- NCT04897919
- Testing
- Dihydroartemisinin-piperaquine 160 mg/20 mg Oral Tablet, Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
- Where
- Guinea-Bissau
- Volunteers
- 474 people
- Sponsor
- Bandim Health Project
Malaria
Determine the Tolerability and Safety of Atovaquone-proguanil (ATV-PG) Co-administered With Amodiaquine (AQ)
The aim of the study is to determine the tolerability and safety of ATV-PG + AQ, ATV-PG + AQ placebo, ATV-PG placebo + AQ, and ATV-PG placebo + AQ placebo administered once daily for 3 days to healthy adult male and female…
- Trial name
- NCT04002687
- Testing
- ATV-PG 1000-400 mg + AQ 612 mg
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
OZ439 PhIIa Study in Plasmodium Falciparum: Extended Observation
This study aims to investigate the concentration dependent effects of OZ439 on the clearance of P. falciparum parasites in patients, specifically the determination of an in-vivo minimum inhibitory concentration (MIC) of OZ439.
- Trial name
- NCT01713621
- Testing
- OZ439
- Where
- 3 sites in Thailand
- Volunteers
- 25 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Diagnoses Disease
Clinical Validation of Novel Malaria Diagnostic Tools for POC Point-of-Care Testing
The aim of this study is to perform a performance evaluation of novel diagnostic tools for detecting malaria in malaria-endemic countries.
- Conditions
- Malaria, Diagnoses Disease, RDT
- Trial name
- NCT06225700
- Where
- Rwanda
- Volunteers
- 509 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Malaria
Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine
The study aims to show that the candidate malaria vaccine GMZ2 is as safe as the already publicly used vaccine against rabies. 40 adult male Gabonese volunteers will be enrolled and randomly allocated to receive either malaria…
- Trial name
- NCT00424944
- Testing
- GMZ2 (malaria vaccine), GMZ2 malaria vaccine, Verorab vaccine
- Where
- Gabon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- African Malaria Network Trust
HIV, Malaria
Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on Antifolate Resistance
At least three studies in sub-Saharan Africa have demonstrated a decrease in morbidity or mortality among HIV-infected adults who took daily cotrimoxazole (trimethoprim sulfamethoxazole) [CTX] prophylaxis.
- Conditions
- HIV, Malaria, Diarrhea, Pneumonia
- Trial name
- NCT00137657
- Testing
- Cotrimoxazole (trimethoprim sulfamethoxazole)
- Where
- Kenya
- Volunteers
- 1,478 people
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, Malaria
Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antiretroviral Therapy Including Lopinavir/Ritonavir in HIV-infected Adults
Despite the clinical significance of potential interactions between antimalarials and antiretrovirals, no drug interaction studies have been published and there is an urgent need to address this gap in current knowledge.
- Trial name
- SEACAT 2_4_2 (NCT00869700)
- Testing
- Artemether/Lumefantrine
- Where
- South Africa
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Malaria, Falciparum
Study of Iron Absorption and Utilization in Asymptomatic Malaria
Anemia is still a main public health problem in sub-Saharan Africa. Anemic women have an increased maternal and perinatal mortality and anemic adults have diminished work capacity.
- Trial name
- NCT01108939
- Testing
- Antimalarial treatment, Observation
- Where
- Benin
- Volunteers
- 23 people
- Sponsor
- Swiss Federal Institute of Technology
Uncomplicated Knowlesi Malaria
P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine
Preliminary studies have supported the background efficacy of local standard anti-malarial medications in the treatment of uncomplicated knowlesi malaria, however there are no current WHO treatment guidelines for this infection.
- Trial name
- CAN KNOW (NCT02001012)
- Testing
- Artemether-lumefantrine combination, Chloroquine
- Where
- 3 sites in Malaysia
- Volunteers
- 123 people
- Sponsor
- Menzies School of Health Research
Malaria, Pregnancy Related
Pregnancy Registry in Mali
This registry will assess pregnancy outcomes through demographic surveillance and prospective data collection at a health facility in Kalifabougou, Mali.
- Trial name
- NCT06468319
- Where
- Mali
- Volunteers
- 9,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Vivax Malaria Without Complication
Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia
Both artemether-lumefantrine and chloroquine are currently used and recommended by Malaysian Ministry of Health as blood stage treatments for non-severe P. vivax and P. knowlesi malaria.
- Trial name
- PRIMAL (NCT02348788)
- Testing
- Artemether-lumefantrine + Primaquine, Chloroquine + Primaquine
- Where
- 3 sites in Malaysia
- Volunteers
- 98 people
- Sponsor
- Menzies School of Health Research
Malaria in Pregnancy, Pregnancy Related
MiMBa Pregnancy Registry
The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester.
- Conditions
- Malaria in Pregnancy, Pregnancy Related, Congenital Anomaly
- Trial name
- NCT04825782
- Where
- 2 sites in Burkina Faso, Kenya
- Volunteers
- 15,391 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria
Safety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum Malaria
This study aims to evaluate the safety and efficacy of a standard chloroquine drug regimen administration supplemented with dehydroepiandrosterone sulfate against drug-resistant malaria.
- Trial name
- NCT00442403
- Testing
- chloroquine, dehydroepiandrosterone sulphate
- Where
- Cameroon
- Volunteers
- 200 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Malaria, Falciparum
Assessment of Artesunate/Mefloquine in the Peruvian Amazon
There is growing evidence of the emergence of P. falciparum resistance to artesunate (a derivative of artemisin) in Southeast Asia.
- Trial name
- Artesunate (NCT02084602)
- Testing
- Artesunate, Mefloquine
- Where
- Peru
- Volunteers
- 45 people
- Sponsor
- Instituto Nacional de Salud. Peru
Malaria, Anemia
Prenatal Iron Supplements: Safety and Efficacy in Tanzania
The purpose of this study is to determine safety and efficacy of prenatal iron supplementation in an area of high malaria burden among women who are not anemic or iron deficient.
- Trial name
- MAL1 (NCT01119612)
- Testing
- Iron
- Where
- Tanzania
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
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