Clinical trials: malaria
Malaria, Malaria, Cerebral
Study of the Safety of Intravenous Artesunate
The purpose of this study is to establish the safety, tolerability, and pharmacokinetics of a multiple dose of the antimalarial drug artesunate.
- Trial name
- NCT00292942
- Testing
- Intravenous Artesunate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Vivax Malaria
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
To determine whether two cheap antifolates (chlorproguanil-dapsone and sulfadoxine-pyrimethamine) which work against falciparum malaria in this region are sufficiently effective against vivax malaria to be deployed in areas where…
- Trial name
- NCT00158561
- Testing
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone
- Where
- Pakistan
- Volunteers
- 750 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Phase 1b Malaria Clinical Trial Using Argemone Mexicana in Healthy Adults in Mali
The main objective is to study the pharmacokinetics, pharmacodynamics and tolerability of the decoction of the aerial parts of Argemone mexicana (AM), administered in healthy volunteers.
- Trial name
- NCT01645254
- Testing
- Argemone mexicana
- Where
- Mali
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Malaria
Evaluation of IR3535 as a Spatial Repellent for Malaria Control.
Mozambique contributes with 5% of global malaria cases, and despite control efforts the Sofala province continues to experience a high burden of malaria.
- Trial name
- REPELMALARIA (NCT04419766)
- Testing
- IR3535 (3-(N-acetyl-N-butyl) aminopropionic acid ethyl ester) house spraying
- Where
- Mozambique
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Malnutrition, Malaria
Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection
The purpose of this study is to determine whether 14 days nutritional supplementation with Ready to use therapeutic Food (RUTF) or micronutrients alone to children having an infection will prevent malnutrition and reduce the…
- Conditions
- Malnutrition, Malaria, Lower Respiratory Tract Infection, Diarrhoea
- Trial name
- NCT01154803
- Testing
- Ready to Use Therapeutic Food (RUTF), Micronutrient Powder (MNP)
- Where
- Nigeria
- Volunteers
- 2,213 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations.
- Trial name
- NCT04157894
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Piperonyl butoxide long-lasting insecticidal net
- Where
- Burkina Faso
- Volunteers
- 5,606 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
Cluster Randomized Trial of Peer Health Education in Malaria in The Gambia
Health promotion in schools aims to improve the health and well being of students by empowering them with the knowledge, skills and confidence to take responsibility for their own health.
- Trial name
- NCT00269178
- Testing
- Peer Health Education Programme
- Where
- The Gambia
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Experimental Human Malaria Infection by PfSPZ
The study is a single center, varied dose, open label study. A maximum of eighteen volunteers will be exposed to live NF54 P. falciparum sporozoites (PfSPZ Challenge) by intradermal injection.
- Trial name
- NCT01086917
- Testing
- PfSPZ Challenge
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Falciparum Malaria
Azithromycin Combination Therapy for the Treatment of Severe Malaria
A randomized controlled trial to assess the safety and efficacy of azithromycin combination therapy for use in severe malaria. This pilot trial will be conducted in uncomplicated malaria patients in southeastern Bangladesh.
- Trial name
- NCT01374126
- Testing
- Artesunate, Azithromycin + Artesunate
- Where
- Bangladesh
- Volunteers
- 75 people
- Sponsor
- Medical University of Vienna
Plasmodium Falciparum Malaria (Uncomplicated)
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs.
A partially blinded randomised controlled non-inferiority trial comparing the efficacy, tolerability and safety of Triple ACTs artemether-lumefantrine+amodiaquine (AL+AQ) and artesunate-mefloquine+piperaquine (ASMQ+PPQ) and the…
- Trial name
- DeTACT-Africa (NCT03923725)
- Testing
- Artemether-lumefantrine+ Amodiaquine (AL+AQ), Artesunate-mefloquine+piperaquine (AS-MQ+PPQ)
- Where
- 8 sites in Burkina Faso, Democratic Republic of the Congo and 6 more
- Volunteers
- 2,583 people
- Sponsor
- University of Oxford
Malaria
Regimen Optimization Trial of PfSPZ Vaccine in Equatorial Guinea
This is a phase 1, randomized regimen optimization study of PfSPZ Vaccine in healthy Equatoguinean volunteers to determine if a condensed, rapid immunization regimen is safe and efficacious.
- Trial name
- NCT03590340
- Testing
- PfSPZ Vaccine, Normal saline, PfSPZ Challenge (for CHMI)
- Where
- Equatorial Guinea
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria,Falciparum
Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F
This phase 1 study aims to assess the safety and tolerability of monoclonal antibody TB31F administered intravenously or subcutaneously at escalating dose levels in healthy, malaria naïve, adults.
- Trial name
- TB31F (NCT04238689)
- Testing
- TB31F
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Pneumonia
Study of Post-Training Supports for Health Workers in Benin
The objective of this study was to determine the effectiveness and cost-effectiveness of a package of interventions to support health workers in Benin (in West Africa) who had been trained to use Integrated Management of…
- Conditions
- Malaria, Pneumonia, Diarrhea, Measles
- Trial name
- NCT00510679
- Testing
- Health worker supports (supervision, job aids, incentives)
- Where
- Benin
- Volunteers
- 1,577 people
- Sponsor
- Centers for Disease Control and Prevention
Plasmodium Vivax Malaria
Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans
The purpose of this study is to demonstrate that volunteers can be safely and reproducibly infected with Plasmodium vivax (P. vivax) by the bites of experimentally infected Anopheles dirus (An. dirus) mosquitoes carrying P.
- Trial name
- Pvivax (NCT00935623)
- Testing
- Malaria Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Plasmodium Falciparum
A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania
This will be a single-centre, open label trial to determine the safety and feasibility of CHMI model using Plasmodium falciparum-infected cryopreserved erythrocytes administered to healthy Tanzanian adults with varying prior…
- Trial name
- NCT04788862
- Testing
- P. falciparum infected erythrocytes
- Where
- Tanzania
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum
Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya
This study is a cluster-randomized controlled trial to evaluate the efficacy of community-based mass screening with a malaria rapid diagnostic test, and treatment of participants with positive tests with an appropriate…
- Trial name
- MSaT (NCT02987270)
- Testing
- Dihydroartemisinin-piperaquine
- Volunteers
- 90,000 people, healthy volunteers welcome
- Sponsor
- Simon Kariuki
Malaria
Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)
The primary objective of the study is to demonstrate and quantify the protective efficacy (PE) of spatial repellent products in reducing the incidence of malaria infection in human cohorts.
- Trial name
- SR-M-ZM (NCT02394522)
- Testing
- Spatial Repellent product with active ingredient (SHIELD), Active Ingredient, Spatial Repellent product without active ingredient (SHIELD)
- Where
- Zambia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Notre Dame
Uncomplicated Plasmodium Falciparum Malaria
Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort B1)
This is Cohort B1 of the Platform study (NCT05750628) to evaluate the efficacy and safety of INE963 + Cipargamin in participants with uncomplicated Plasmodium falciparum malaria.
- Trial name
- PLATINUM (NCT07811882)
- Testing
- KAE609 (Cipargamin), SoC (Coartem), INE963
- Where
- 13 sites in Burkina Faso, Côte d’Ivoire and 5 more
- Volunteers
- 95 people
- Sponsor
- Novartis Pharmaceuticals
Malaria,Falciparum
First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367
This three-part, first-in-human, healthy volunteer study aims to assess the safety and tolerability of the test medicine as well as how it is taken up by the body when given as single and multiple doses.
- Trial name
- NCT05507970
- Testing
- MMV367, MMV367 (Fed 440mg), MMV367 (Fasted 440mg)
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria, Anemia
Evaluation of Seasonal Malaria Chemoprevention in Kita
Seasonal malaria chemoprevention (SMC) is a new strategy recommended by World Health Organization in 2012 for areas of highly seasonal transmission such as the Sahel.
- Trial name
- NCT02894294
- Testing
- implementation of seasonal malaria chemoprevention
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- University of Bamako
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