Clinical trials: malaria
Day-3 Positive of Parasitaemia, Prevalence of Drug Resistance Gene Mutation
Molecular Assessment of Artemisinin Resistance Markers in Eastern and Western Border Areas of Myanmar
Artemisinin resistance have been documented in Myanmar and Myanmar artemisinin resistance containment measures have been launched since 2009-2010.
- Trial name
- NCT02198573
- Where
- Burma
- Volunteers
- 91 people
- Sponsor
- Myat Htut Nyunt
Malaria
Tafenoquine/Chloroquine DDI Study
DDI study of Tafenoquine and Chloroquine
- Trial name
- NCT00871156
- Testing
- Chloroquine, Tafenoquine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum
This was a randomised, double-blind, placebo-controlled study to compare the efficacy of a range four weekly doses of tafenoquine, and weekly mefloquine, with placebo as chemosuppression of P. falciparum malaria.
- Trial name
- NCT02488902
- Testing
- Tafenoquine 25mg, Tafenoquine 50mg, Tafenoquine 100 mg
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
MaCRA Part B in Côte d'Ivoire
This study aims to evaluate the effectiveness of monthly malaria rapid diagnostic test (RDT) validation meetings at district level on reducing the proportion of RDT results recorded as positive in health facility registers in…
- Trial name
- NCT06804902
- Testing
- Monthly RDT Validation Meeting
- Where
- Côte d’Ivoire
- Volunteers
- healthy volunteers welcome
- Sponsor
- PATH
Malaria
Gut and Azithromycin Mechanisms in Infants and Children II
Childhood mortality is decreasing worldwide. However, many sub-Saharan countries still have high children under 5 mortality rates.
- Trial name
- GAMINII (NCT04315272)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Falciparum Malaria
Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon
Malaria remains a major public health concern in Cameroon especially among vulnerable groups such as children less than five years and pregnant women.
- Trial name
- NCT04829695
- Testing
- Artesunate-amodiaquine drug combination, Artemether-lumefantrine drug combination
- Volunteers
- 184 people
- Sponsor
- University of Yaounde 1
Malaria, Dengue
Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia. Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people…
- Conditions
- Malaria, Dengue, Japanese Encephalitis
- Trial name
- NCT00938379
- Testing
- 20% deet insect repellent
- Where
- Laos
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Vivax
A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solution
This study will investigate the effect of Tafenoquine (TQ) 150 mg tablet ageing (dissolution profiles) on human exposure of TQ comparing the relative bioavailability of TQ from tablets exhibiting different dissolution profiles in…
- Trial name
- NCT02751294
- Testing
- Tafenoquine Control, Tafenoquine dissolution profile X, Tafenoquine SIL
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers
In this study, the investigators are interested to know if lower doses of Primaquine together with dihydroartemisinin-piperaquine can produce a similar effect of clearing both sexual and asexual parasites in asymptomatic carriers…
- Trial name
- PRINOGAM (NCT01838902)
- Testing
- DHA-PPQ, PQ (0.75), PQ (0.4)
- Where
- The Gambia
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Malaria
The Synergistic Effects of Home-management and Intermittent Preventive Treatment of Malaria in Children
This cluster randomised trial is proposed to assess the clinical impact of adding a seasonal intermittent preventive treatment (IPTc) schedule for children aged 3 -59 months to a home management of malaria (HMM) programme using…
- Trial name
- KNUST-COMDIS (NCT00550160)
- Testing
- Amodiaquine plus Artesunate co-administration
- Where
- Ghana
- Volunteers
- 1,490 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Malaria
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo
This will be an open-randomised non-inferiority study to test the hypothesis that the risk of recurrent parasitaemia after 42 days is not worse in the group receiving the Artesunate-Amodiaquine (ASAQ) regimen than in the group…
- Trial name
- NCT02741024
- Testing
- Amodiaquine-Artesunate (ASAQ), Artemether-Lumefantrine (AL)
- Volunteers
- 288 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Malaria
VAC063C: A Study to Assess Repeat Blood-stage P. Falciparum Infection
This is a clinical study to assess the safety of primary, secondary and tertiary blood-stage controlled human Plasmodium falciparum malaria infection of healthy malaria-naïve UK adults, as well as to evaluate any effect of prior…
- Trial name
- NCT03906474
- Testing
- Blood-stage controlled human P. falciparum malaria infection
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum
VAC077: Safety and Immunogenicity of the Pfs25-IMX313/Matrix-M Vaccine
This is an open label, single-site, first-in-human, Phase Ia study to assess safety and immunogenicity of the Plasmodium falciparum malaria vaccine candidate Pfs25-IMX313 in Matrix-M1 adjuvant in healthy adults living in the UK…
- Trial name
- NCT04130282
- Testing
- Pfs25-IMX313/Matrix-M1
- Where
- United Kingdom
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults
This is an open-label pharmacokinetic study in 24 healthy Thai participants. Participants will be admitted in the inpatient ward and each participant will attend a total of 4 visits, including one screening visit and three…
- Trial name
- APP (NCT07470424)
- Testing
- Piperaquine, Artesunate-pyronaridine (Pyramax), Piperaquine and artesunate-pyronaridine (Pyramax)
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Chemopreventive Therapy for Malaria in Ugandan Children
Young African children living in high transmission areas suffer the greatest burden of malaria. In most African countries, such as Uganda, the only current preventive measure against malaria in high transmission settings is the…
- Trial name
- PROMOTE-Chemop (NCT00948896)
- Testing
- trimethoprim-sulfamethoxazole (TS; TMP/SMX), sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Plasmodium Falciparum
A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5
The purpose of this study is to assess two new malaria vaccines, ChAd63 RH5 and MVA RH5, at different doses and alone or in combination.
- Trial name
- NCT02181088
- Testing
- ChAd63 RH5 low dose, ChAd63 RH5 full dose, MVA RH5 low dose
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Glucose 6 Phosphate Dehydrogenase Deficiency
Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen
To investigate the comparative tolerability, metabolism and pharmacokinetics of individual enantiomers of PQ in healthy human volunteers, receiving study drug over the course of 7 days.
- Trial name
- NCT03934450
- Testing
- RPQ, SPQ, Primaquine Phosphate
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Malaria
Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, Liberia
Background: Malaria is a disease that affects many people in Liberia. It is caused by germs (parasites) that are spread by mosquito bites.
- Trial name
- NCT04704674
- Where
- Liberia
- Volunteers
- 396 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Cardiac Safety of Repeated Doses of Dihydroartemisinin-Piperaquine for the Use in Mass Treatment Campaigns
Mass drug administration with antimalarial treatment is a tool that can potentially reduce or totally eliminate malaria parasite infections from a population.
- Trial name
- ECG-Lihir (NCT02605720)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- Papua New Guinea
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
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