Clinical trials: malaria
Severe Malaria
Study to Compare Feasibility of 1-step Injectable Artesunate vs. Conventional 2-step Injectable Artesunate
The objectives of this study contains 3 parts: (1) a comparison of 1-step parenteral artesunate (AS) versus conventional 2-step parenteral artesunate in patients with severe malaria to assess the feasibility of administration…
- Trial name
- 1STEP-AS (NCT05140278)
- Testing
- Argesun 60mg (1 step parenteral artesunate), Artesun 60mg (2-step parenteral artesunate)
- Where
- Democratic Republic of the Congo
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Malaria, Fever
Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Malaria is a common, but decreasing, cause of fever in endemic areas. The use of rapid diagnostic tests could improve treatment of malaria at the local community level. Deployment of these tests is, however, a considerable cost.
- Conditions
- Malaria, Fever, Acute Febrile Illness, Pneumonia
- Trial name
- NCT01403350
- Testing
- Malaria Rapid Diagnostic test
- Where
- 3 sites in Afghanistan
- Volunteers
- 2,421 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Falciparum
Prevalence Survey of Plasmodium Falciparum Antimalarial Drug Resistance Markers
This study is to measure prevalence of established and candidate molecular markers of drug resistant malaria at Komé, Doba, Republic of Chad.
- Trial name
- NCT02895568
- Where
- Chad
- Volunteers
- 399 people
- Sponsor
- University of Oxford
Malaria, Malaria,Falciparum
A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI
USSPZV7 is a randomized, phase 1, double-blind, placebo-controlled trial of Sanaria® PfSPZ Vaccine administered on Days 1, 8 and 29 by direct venous inoculation (DVI) to assess safety, tolerability, immunogenicity, and vaccine…
- Trial name
- NCT05604521
- Testing
- PfSPZ Vaccine, PfSPZ Challenge (7G8), Normal Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Cerebral Malaria
Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria
Cerebral malaria is the most lethal complication of P.falciparum infection with a mortality rate between 5 and 40%. Intravenous quinine remains the recommended treatment for cerebral malaria.
- Trial name
- NCT00124267
- Testing
- Intrarectal quinine
- Where
- Uganda
- Volunteers
- 108 people
- Sponsor
- Makerere University
Malaria
A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria
The primary objective is to assess the safety of different doses of ferroquine with artesunate (AS) in adult African patients with uncomplicated malaria.
- Trial name
- NCT00563914
- Testing
- ferroquine (SSR97193), amodiaquine
- Where
- 2 sites in Gabon, Kenya
- Volunteers
- 72 people
- Sponsor
- Sanofi
Malaria in Pregnancy
Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy
Malaria is a major contributor of disease burden in Sub-Saharan Africa, and pregnant women and children are the most vulnerable population.
- Trial name
- NCT00711906
- Testing
- Cotrimoxazole, Sulfadoxine-pyrimethamine
- Where
- 2 sites in Zambia
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Study of SAR97276A in the Treatment of Uncomplicated and Severe Malaria in Adults and Children.
The objective of the study is to assess the efficacy and safety of SAR97276A in severe malaria in pediatric patients. Before treating pediatric patients with severe malaria, the efficacy and safety of SAR97276A will be first…
- Trial name
- NCT00739206
- Testing
- SAR97276A
- Where
- 4 sites in Benin, Burkina Faso and 2 more
- Volunteers
- 113 people
- Sponsor
- Sanofi
Malaria
Trial to Evaluate CIS43LS in Healthy Adults
Background: People get malaria when they are bitten by an infected mosquito. Malaria can be serious and sometimes deadly. Although there are medicines to treat malaria, there is no vaccine that fully prevents infection.
- Trial name
- NCT04206332
- Testing
- VRC-MALMAB0100-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
GMZ2-Aluminum Hydroxide Phase I, Tübingen
This is a randomized, open, dose-selection Phase 1 study. The study aims to evaluate the safety and immunogenicity of 3 doses (10,30 \& 100 micrograms) of the GMZ2 hybrid (GLURP and MSP3) blood stage vaccine in healthy non-immune…
- Trial name
- NCT00397449
- Testing
- GMZ2 (GLURP + MSP3 Hybrid) (malaria vaccine)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria, Falciparum
Chlorproguanil-Dapsone-Artesunate Versus COARTEM For Uncomplicated Malaria
Chlorproguanil-dapsone has been approved for the treatment of uncomplicated Plasmodium falciparum malaria in a number of countries across sub-Sahara Africa, and by the UK's Medicines and Healthcare products Regulatory Agency.
- Trial name
- NCT00344006
- Testing
- chlorproguanil-dapsone-artesunate, artemether-lumefantrine
- Where
- 9 sites in Burkina Faso, Ghana and 3 more
- Volunteers
- 1,395 people
- Sponsor
- GlaxoSmithKline
Malaria
A Study to Assess the Safety and Immunogenicity of a Candidate Malaria Vaccine Using Novel Routes of Administration
The purpose of this study is to assess the safety and immunogenicity of novel routes of administration of the candidate malaria vaccines ChAd63 encoding ME-TRAP and MVA encoding ME-TRAP.
- Trial name
- NCT03084289
- Testing
- ChAd63-METRAP, MVA ME-TRAP
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Falciparum
Perennial Malaria Chemoprevention in the Malaria Vaccine Era
Malaria remains a major cause of pediatric deaths and morbidity in Africa. An affordable malaria vaccine, R21, is being deployed in Uganda and other African countries with high malaria transmission, but efficacy is incomplete and…
- Trial name
- PMC-VAC (NCT07322068)
- Testing
- Sulfadoxine pyrimethamine + Amodiaquine, Dihydroartemisinin Piperaquine
- Where
- Uganda
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Stanford University
Malaria, Fever
Training in Fever Case Management With Rapid Diagnostic Tests (RDTs) for Malaria in Uganda
Malaria remains one of the most devastating infectious diseases in the world. Despite the potential for serious adverse outcomes with each episode of malaria, most cases in endemic areas are diagnosed on clinical grounds alone.
- Trial name
- NCT00716599
- Testing
- training in use of rapid diagnostic tests (RDTs) for malaria
- Where
- Uganda
- Volunteers
- 14,000 people
- Sponsor
- University of California, San Francisco
Drug Resistance, Plasmodium Falciparum Malaria
Molecular Surveillance of Artemisinin Resistance Malaria in Myanmar
Efficacy and safety of the artemisinin combination therapy (ACT) in uncomplicated falciparum malaria patients in Myanmar and artemisinin molecular markers analysis
- Trial name
- NCT02792816
- Testing
- First line antimalarial in Myanmar (artemether-lumefrantrine, dihydroartemisinin-piperaquine, and artesunate-mefloquine)
- Where
- Burma
- Volunteers
- 550 people
- Sponsor
- Department of Medical Research, Lower Myanmar
Malaria, Cerebral
Treating Brain Swelling in Pediatric Cerebral Malaria
This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as…
- Trial name
- TBS (NCT03300648)
- Testing
- Mechanical ventilation, Hypertonic saline
- Where
- Malawi
- Volunteers
- 57 people
- Sponsor
- Michigan State University
Severe Malaria
Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate for Severe Malaria Treatment
Intravenous artesunate is highly effective with rapid schizonticidal action and improved clinical outcome
- Trial name
- NCT01122134
- Testing
- intravenous artesunate
- Where
- Uganda
- Volunteers
- 20 people
- Sponsor
- Makerere University
Malaria,Falciparum
Safety, Pharmacokinetics, and Plasmodium Falciparum Transmission-reducing Activity of Monoclonal Antibody TB31F in Mali
Mali faces a significant challenge with malaria, particularly among its younger population. While existing measures like seasonal chemoprevention and vaccination have shown efficacy, further innovations are necessary to combat…
- Trial name
- NCT06413108
- Testing
- TB31F, Normal saline
- Where
- Mali
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Febrile Illness
Village Malaria Worker Expansion
This project will conduct pragmatic operational research in rural communities served by approximately 12 health centres and 120 village malaria workers in Battambang/Pailin, western Cambodia.
- Trial name
- CAM-VMW (NCT05045547)
- Where
- Cambodia
- Volunteers
- 7,191 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Asymptomatic Parasitaemia
Community-Based Cohort Study of Hidden Malaria Infections, Diagnostic Gaps, & Mosquito Vector Dynamics in Odisha, India
The goal of this prospective cohort study is to understand the factors responsible for the persistence of malaria transmission in some areas despite intensive control efforts.
- Trial name
- CSCMi3 (NCT07770048)
- Where
- 2 sites in India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.