Clinical trials: microRNA
Major Depressive Disorder
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are…
- Trial name
- NCT02418195
- Testing
- ketamine
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Asthma
Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics
This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen challenge.
- Trial name
- ACE (NCT02230189)
- Testing
- Segmental airway allergen challenge, Bronchoscopy, Methacholine challenge test
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Prescott Woodruff
Endometriosis
MicroRNA Activation of LOX-1 Mechanisms in Endometriosis
Endometriosis is a disorder that occurs in women. With endometriosis, tissue that should be found in the womb is found in sites outside of the womb.
- Trial name
- NCT05331053
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Dexamethasone Effect on miRNA Profile in Healthy Humans
Detection of miRNAs in HPA Axis Function in Healthy Subjects
The proposed study will test dexamethasone effect on miRNA profile in healthy humans. As our data indicate that miRNA levels change over time, the investigators will study the time course of miRNA response to 1 mg IV…
- Trial name
- NCT04066647
- Testing
- Dexamethasone 4mg
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Frailty
Enhancing Functional Capacity in Older Adults With Short Session High Intensity Interval Training
Frailty is a clinical condition of poor physiological reserve that increases risks for adverse health outcomes including falls, hospitalization and mortality.
- Trial name
- HIIT-VA (NCT03750006)
- Testing
- Short session HIIT
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Glycogen Depletion
Carbohydrate Availability and microRNA Expression
This investigation will examine the impact of skeletal muscle glycogen stores on skeletal muscle and circulating microRNA expression and exogenous carbohydrate oxidation.
- Trial name
- NCT03250234
- Testing
- Adequate Carbohydrate, Low Carbohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Asthma
Role of microRNAs in T Cell-Driven Inflammation in Asthma
This will be a single center study of asthmatic subjects and healthy controls which will investigate mechanisms of asthma through detailed molecular analysis of airway tissues and fluids.
- Trial name
- RITA (NCT01484691)
- Testing
- Budesonide
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Adiposity, Insulin Resistance
PREterM FOrmula Or Donor Breast Milk for Premature Babies
In order to address this crucial question, central to preterm newborn care, a multicentre United Kingdom (UK) -wide study randomising 4000 preterm babies would be necessary to achieve sufficient power to evaluate the impact on…
- Conditions
- Adiposity, Insulin Resistance, Metabolomic Profile, microRNA Profile
- Trial name
- PREMFOOD (NCT01686477)
- Testing
- Unfortified Human donor Milk used to make up any shortfall in mother's own milk, Fortified Human donor Milk used to make up any shortfall in mother's own milk, Preterm Formula used when there is a shortfall in mother's own milk
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London