Clinical trials: multiple sclerosis
Multiple Sclerosis
Isokinetic Exercises in Patients With Multiple Sclerosis
The investigators evaluated the effects of isokinetic muscle strengthening exercises of the quadriceps and hamstring on muscle strength, joint position sense, pain, kinesiophobia and quality of life in patients with multiple…
- Trial name
- NCT03779724
- Testing
- exercises
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Aksaray University Training and Research Hospital
Relapsing Remitting Multiple Sclerosis (RRMS)
A Prospective, Open-label, Non-randomized, Clinical Trial to Determine if Natalizumab (Tysabri®) Improves Ambulatory Measures in Relapsing-remitting Multiple Sclerosis (RRMS) Patients
The primary objective of the study is to evaluate the evolution of walking capacity as measured by the timed 100-meter walk test (T100T), timed 25-foot walk test (T25FW), maximum walking distance (MWD), and Expanded Disability…
- Trial name
- TIMER (NCT00871780)
- Testing
- BG00002 (natalizumab)
- Where
- 15 sites in Belgium, Mexico and 4 more
- Volunteers
- 224 people
- Sponsor
- Biogen
Multiple Sclerosis, Endurance
Comparison of Intermittent vs. Continuous Walking in MS
Objective: To compare effects of an intermittent and continuous walking program on walking endurance and fatigue in people with multiple sclerosis (MS).A randomized crossover prospective method was used.The intervention consisted…
- Trial name
- NCT02726373
- Testing
- type of walking
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Multiple Sclerosis, Stroke
PLasmatic Extracellular Vesicles AS Biomarkers of nEural Tissue Damage
Recently proposed central nervous system damage biomarkers detectable in biofluids, such as neurofilament light chain (NfL) have several limits, including a lack in specificity and a kinetic that does not allow them to be used as…
- Trial name
- PLEASE (NCT07769294)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Roberto Furlan
Multiple Sclerosis (MS) - Relapsing-remitting
Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)
This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.
- Trial name
- ADVICE Phase 2 (NCT06884579)
- Testing
- Strength training, nutrition, and behavioral training, Self-Guided and Unsupervised Program with General Recommendations
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Almeria
Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis
Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis
A key question in efforts to reduce symptoms and improve quality of life for multiple sclerosis (MS) patients is whether a therapeutic lifestyle (diet, stress reduction and exercise) is inferior to disease-modifying drug…
- Trial name
- NCT04009005
- Testing
- Therapeutic diet and lifestyle
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Terry L. Wahls
Digital Ulcers in Systemic Sclerosis
Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis
The main goal of this clinical trial is to learn about how safe the new drug TOP-N53 solution is when it is applied to open wounds on the fingertip (digital ulcers) in people with an uncommon illness that results in hard…
- Trial name
- TOP-N53-02 (NCT06954597)
- Testing
- TOP-N53, Sildenafil, TOP-N53 vehicle
- Where
- 6 sites in France, Switzerland
- Volunteers
- 15 people
- Sponsor
- Topadur Pharma AG
Multiple Sclerosis, Multiple Sclerosis, Primary Progressive
Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosis
This study evaluates the effectiveness of N-acetyl cysteine (NAC) in the treatment of progressive multiple sclerosis. Half of the patients will receive NAC, while the other half will receive a placebo.
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NACPMS (NCT05122559)
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Emmanuelle Waubant, MD PhD
Multiple Sclerosis
Emotional Processing, Family Life, Friendship and Social Integration in Patients With Multiple Sclerosis
In addition to the physical, cognitive and psychological symptoms experienced by individuals with Multiple Sclerosis (MS), there is new research which indicates that some individuals with MS have a deficit in emotional…
- Trial name
- EMOSOCIAL-MS (NCT02708927)
- Testing
- Clinical evaluation, Cognitive evaluation
- Where
- 2 sites in France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis, Clinically Isolated Syndrome
AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MS
The definition of the most 'at-risk' population within highly susceptible groups would provide an opportunity for preemptive therapeutics.
- Trial name
- ARMS (NCT00617383)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Central Nervous System (CNS) Demyelinating Disease, Multiple Sclerosis
Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants
The primary objective of this study is to assess the safety and tolerability of a single dose and multiple doses of BIIB033 administered to healthy adult Japanese participants.
- Trial name
- NCT02641041
- Testing
- BIIB033
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biogen
Autoimmune Diseases, Non-small Cell Lung Cancer
Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease
The purpose of this study is to explore the safety, tolerability and activity of Nivolumab, a PD-1 inhibitor, in cohorts of patients with autoimmune disease.
- Conditions
- Autoimmune Diseases, Non-small Cell Lung Cancer, Rheumatoid Arthritis, Psoriasis
- Trial name
- NCT03656627
- Testing
- Nivolumab
- Where
- 9 sites in United States
- Volunteers
- 7 people
- Sponsor
- Alliance Foundation Trials, LLC.
Progressive Multiple Sclerosis
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
The main purpose of this study is to assess the efficacy of RO7268489 in adults with progressive multiple sclerosis (PMS) receiving ocrelizumab.
- Trial name
- Mintaka (NCT07282574)
- Testing
- RO7268489, Ocrelizumab
- Where
- 114 sites in Australia, Brazil and 10 more
- Volunteers
- 360 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
Finding Patterns In Clinical Study Experiences of Multiple Sclerosis Patients
Participation in medical trials usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups.
- Trial name
- NCT05503524
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Multiple Sclerosis
tDCS for the Management of Multiple Sclerosis Related Fatigue
This is a pragmatic clinical trial that aims to determine the effect of tDCS on symptomatic fatigue in Multiple Sclerosis (MS) patients.
- Trial name
- NCT03838770
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis (MS)
A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis
A randomized multiple baseline feasibility trial where participants will start taking metformin at one of 3 randomly determined points (3-months, 6-months or 9 months) during the 12-month trial.
- Trial name
- NCT04121468
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis
Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis
The proposed study is a pilot study of ublituximab involving people with multiple sclerosis (MS) who are experiencing a "wearing off" phenomenon (return or worsening of MS-related symptoms) while being treated with ocrelizumab…
- Trial name
- NCT07389590
- Testing
- Ublituximab, Ocrelizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Amyotrophic Lateral Sclerosis
A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS)
The primary purpose of this study is to evaluate the safety and tolerability of VRG50635 in participants with ALS.
- Trial name
- NCT06215755
- Testing
- VRG50635
- Where
- 7 sites in Belgium, Canada and 2 more
- Volunteers
- 54 people
- Sponsor
- Verge Genomics
Multiple Sclerosis
Jacobson's Progressive Muscle Relaxation for Fatigue and Kinesiophobia in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurological condition that can cause fatigue and fear of movement (kinesiophobia), which may interfere with daily activities and participation in rehabilitation.
- Trial name
- JPMRT (NCT07854691)
- Testing
- Jacobson's Progressive Muscle Relaxation Technique (JPMRT), Routine Care
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Al-Zaytoonah University of Jordan
Multiple Sclerosis
Home-based Action Observation Treatment With Virtual-reality for Arm Rehabilitation in People With Multiple Sclerosis
Action Observation Treatment (AOT) is a rehabilitative strategy which has been proposed as a promising approach to improve motor performance in neurological conditions, including multiple sclerosis (MS).
- Trial name
- NCT05713890
- Testing
- Home-based Action Observation Treatment with virtual-reality for upper limb rehabilitation, Home-based landscape observation with virtual-reality for upper limb rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
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