Clinical trials: multiple sclerosis
Relapsing Multiple Sclerosis
To Evaluate the Safety and Efficacy of Teriflunomide in Patients With Relapsing Forms of Multiple Sclerosis
Primary Objective: To describe the safety of teriflunomide in patients with relapsing forms of multiple sclerosis. Secondary Objective: To describe the efficacy of teriflunomide in patients with relapsing forms of multiple…
- Trial name
- SAFE (NCT03856619)
- Testing
- TERIFLUNOMIDE HMR1726
- Where
- 14 sites in India
- Volunteers
- 121 people
- Sponsor
- Sanofi
Multiple Sclerosis (MS)
A Study on the Safety and Tolerability of Universal STAR-T Cell Therapy for Multiple Sclerosis.
This is a Phase I, single-arm, open-label, dose-escalation and dose-expansion study. The main objective is to explore the safety and tolerability of the universal STAR-T cell injection in patients with progressive or…
- Trial name
- NCT07523100
- Testing
- Universal STAR-T Cell Injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Daishi Tian
Multiple Sclerosis
A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies
In this study, researchers will learn more about the effects of diroximel fumarate (DRF), also known as VUMERITY®, when taken during pregnancy in people with multiple sclerosis, also known as MS.
- Trial name
- NCT05688436
- Testing
- Diroximel Fumarate, Alemtuzumab, Fingolimod
- Where
- United States
- Volunteers
- 1,178 people
- Sponsor
- Biogen
Multiple Sclerosis
Observational Study for Assessment of the Effect of Fampyra on the Manual Function of Persons With Multiple Sclerosis
Multiple Sclerosis (MS) is the most common chronic neurological disease affecting young adults, with onset usually at age 20-40 years. Women are affected 3-4 times more than men.
- Trial name
- NCT01547234
- Where
- Israel
- Volunteers
- 47 people
- Sponsor
- Carmel Medical Center
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
Imaging of Intracerebral Inflammation in MS
In this study we plan to image the compartmentalized inflammation in MS using molecular imaging by positron emission tomography (PET) with a very highly resolutive camera.
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Primary Progressive
- Trial name
- INFLASEP (NCT02305264)
- Testing
- 18F-DPA-714 and 18F-FDG
- Where
- 2 sites in France
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
The Multicenter, Open-label, Single-use Autoinjector Convenience Study
The purpose of this trial is to test the Single-Use Autoinjector for a) ease of use; b) multiple domains related to subject's acceptability and satisfaction, and c) reliability of the correct function for self-injection of Rebif®…
- Trial name
- NCT00958009
- Testing
- Rebidose®
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- EMD Serono
Multiple Sclerosis
Visual Impairment, Oscillopsia and Multiple Sclerosis
This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis.
- Trial name
- NCT00498199
- Testing
- visual tests
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Relapsing Forms of Multiple Sclerosis
A Study to Learn About the Safety of Diroximel Fumarate (DRF) and Dimethyl Fumarate (DMF) and Their Effects on Relapses in Pediatric Participants With Relapsing Forms of Multiple Sclerosis (RMS)
In this study, researchers will learn more about the study drugs diroximel fumarate (DRF) and dimethyl fumarate (DMF) in children with MS who may be experiencing relapses.
- Trial name
- VOYAGE (NCT07483632)
- Testing
- Diroximel Fumarate, Dimethyl Fumarate, Fingolimod
- Volunteers
- 185 people
- Sponsor
- Biogen
Multiple Sclerosis, Stroke
Taxonomy of Neurorehabilitation Treatments and Outcome Measures: a Multicentre Italian Study
The main aims of the observational study are to taxonomize the contents of rehabilitation understanding goals and treatments provided to people with Parkinson Disease(PD) and Multiple Sclerosis(MS) and Stroke and their impact on…
- Conditions
- Multiple Sclerosis, Stroke, Parkinson Disease
- Trial name
- NCT04386863
- Where
- 7 sites in Italy
- Volunteers
- 204 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
The Role of Exercise in Modifying Outcomes for People With Multiple Sclerosis
Despite the benefits of exercise and physical activity people with Multiple Sclerosis (MS) are relatively inactive. Physical activity is important for persons with disabilities to maintain physical function.
- Trial name
- MStep (NCT01611987)
- Testing
- MStep, General guideline approach
- Where
- 5 sites in Canada
- Volunteers
- 240 people
- Sponsor
- McGill University
Multiple Sclerosis, Cognitive Disorders
Effect of Transcutaneous Electrical Nerve Stimulation on Cognition in Multiple Sclerosis Patients
The aim of this study is to evaluate whether the Transcutaneous Electrical Nerve Stimulation (TENS) is effective on improvement of cognitive disorders in Multiple sclerosis patients.
- Trial name
- NCT02876536
- Testing
- TENS
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Isfahan University of Medical Sciences
NMO and MS
Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study
To compare the frequency and patterns of autonomic dysfunction in patients with NMOSD and MS, and to investigate its correlations with clinical disability, radiological findings, fatigue, and quality of life parameters
- Trial name
- English Title (NCT07273292)
- Testing
- Bedside cardiovascular reflex tests
- Volunteers
- 100 people
- Sponsor
- Mohamed Moshref abd alsattar
Pain, Spinal Cord Injuries
Cognitive Testing for the Pain Quality Assessment Scale (PQAS)
The purpose of the study is to improve a questionnaire (the Pain Quality Assessment Scale) used for measuring different types of pain people may experience.
- Conditions
- Pain, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- PQAS (NCT00715598)
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of Washington
Multiple Sclerosis, Healthy Nutrition
Probiotic Chocolate Study in Multiple Sclerosis
The goal of this study is to assess the effects of probiotics on persons with multiple sclerosis (MS), persons at higher genetic risk for MS (first degree family members of persons with MS), and healthy controls.
- Trial name
- ProChocolate (NCT06475183)
- Testing
- Bouchard Belgian Dark Chocolate Probiotic Napolitains, containing bifidobacterium longum
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis
Improving New Learning and Memory in Multiple Sclerosis
The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in Multiple Sclerosis (MS).
- Trial name
- NCT00166283
- Testing
- memory retraining exercises
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Kessler Foundation
Tuberous Sclerosis Complex
Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy
This is a Phase 3, global, open-label extension (OLE) study of adjunctive GNX treatment in children and adults with TSC who previously participated in either Study 1042-TSC-3001 or Study 1042-TSC-2001
- Trial name
- NCT05604170
- Testing
- Ganaxolone
- Where
- 54 sites in United States, Australia and 8 more
- Volunteers
- 117 people
- Sponsor
- Marinus Pharmaceuticals
Multiple Sclerosis, Neurogenic Bladder Disorder
Effects of Pelvic Floor Strengthening and Relaxation Exercises in Women Diagnosed With Multiple Sclerosis
The aim of this study was to compare the effects of pelvic floor strengthening and relaxation exercises on lower urinary tract dysfunction (LUTD), depression and quality of life (QoL) in women with Multiple Sclerosis (WwMS).
- Conditions
- Multiple Sclerosis, Neurogenic Bladder Disorder, Pelvic Floor Muscle Exercise
- Trial name
- NCT07485556
- Testing
- Pelvic Floor Strengthening Exercises, Pelvic Floor Relaxation Exercises, Combined Pelvic Floor Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Gazi University
Amyotrophic Lateral Sclerosis
A Study of IPL344 in the Treatment of ALS Patients
This is a prospective, open-label, phase 1/2a study, dose escalation, to evaluate tolerability, safety, and PK of I.V. administered IPL344 in participants with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- ALS (NCT03652805)
- Testing
- IPL344
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Immunity Pharma Ltd.
Multiple Sclerosis
Clinical Investigation of the Quality of Life Benefit of Using a Home Walking Exoskeleton for a Population of Multiple Sclerosis Patients.
The goal of this clinical investigation is to evaluate the effectiveness of home use of a lightweight robotic lower limb exoskeleton as a walking aid device on quality of life in patients with multiple sclerosis with gait…
- Trial name
- EXHOMESEP (NCT05835622)
- Testing
- Keeogo, adviced home practice
- Where
- 6 sites in France
- Volunteers
- 28 people
- Sponsor
- Pôle Saint Hélier
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
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