Clinical trials: multiple sclerosis
Multiple Sclerosis
Prospective Effectiveness and Safety Study of Cladribine in Participants Who Change First-line DMD Treatments for Multiple Sclerosis (CLAD CROSS)
The main aim was to study in the real world setting the effectiveness of Cladribine tablets in terms of Annualized Relapse Rate (ARR) and disability progression, in participants who switched from a first line Disease Modifying…
- Trial name
- NCT04934800
- Testing
- Cladribine
- Where
- 61 sites in Austria, Greece and 5 more
- Volunteers
- 256 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Multiple Sclerosis
Non-invasive Electrical Spinal Cord Stimulation To Restore Upper Extremity Function in Multiple Sclerosis
Current disease-modifying therapies for multiple sclerosis (MS) aim to prevent the development of new lesions; unfortunately, no current FDA-approved therapies promote central nervous system (CNS) repair mechanisms.
- Trial name
- NCT06552611
- Testing
- Transcutaneous electrical spinal cord stimulation + therapy, Occupational Therapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Multiple Sclerosis, Spinal Cord Injury
PURO - PUlmonary Rehabilitation With O-RAGT Platform
The goal of this interventional study is to assess differences in the metabolic consumption, the cardiorespiratory effort, the cardiac autonomic adaptation, and fatigability during ADL, such as standing from a chair and walking…
- Conditions
- Multiple Sclerosis, Spinal Cord Injury, Stroke, Traumatic Brain Damage
- Trial name
- PURO (NCT05757830)
- Testing
- UANGO suite exoskeleton
- Where
- 4 sites in Italy, Lithuania and 2 more
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Central Nervous System Diseases, Multiple Sclerosis
Diagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory Diseases
Numerous studies have shown the diagnostic interest of cerebrospinal fluid kappa free light chains and kappa index in multiple sclerosis.
- Trial name
- NCT05088473
- Testing
- Biological collection
- Where
- 14 sites in France
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
Dual Task Cost in the Upper Limb in Persons With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative disorder of the central nervous system, with more than 2.5 million people in the world.
- Trial name
- DTC (NCT02493166)
- Testing
- dual task cost (cognitive-motor interference)
- Where
- 4 sites in Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Effect of Aerobic Training vs Balance Training on Fatigue Symptom in Multiple Sclerosis Patient (FATI-gate)
Fatigue and impaired balance frequently affect patients with Multiple Sclerosis (MS). This is an open, prospective randomised crossover trial aimed at clarifying whether an improvement in balance control after balance training…
- Trial name
- FATI-gate (NCT06051019)
- Testing
- Aerobic training, Balance training
- Volunteers
- 39 people
- Sponsor
- Istituto Auxologico Italiano
Multiple Sclerosis
Mesenchymal Stem Cell Transplantation in MS
The study is a randomized Phase II study, masked and crossed-over with placebo to evaluate the safety and tolerability of autologous mesenchymal stem cell transplantation in patients with active multiple sclerosis
- Trial name
- CMM-EM (NCT01228266)
- Testing
- autologous mesenchymal stem cells
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Albert Saiz
Multiple Sclerosis, Cognitive Impairment
Cognitive-motor Dual Task Training in Patients With Multiple Sclerosis
Clinical features of Multiple Sclerosis (MS) vary widely from patient to other. About the 60% of patients with MS presents cognitive deficits associated with motor disability.
- Conditions
- Multiple Sclerosis, Cognitive Impairment, Motor Disorders
- Trial name
- NCT04619953
- Testing
- Dynamic Postural Stability Training, Cognitive-Motor Training, Conventional Therapy
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Facial Angiofibroma, Tuberous Sclerosis
Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex
The study aims to compare the safety and efficacy of two different strengths of Rapamycin cream, topical and placebo over 26 weeks in the treatment of facial angiofibroma (FA) associated with Tuberous Sclerosis Complex (TSC).
- Trial name
- NCT03826628
- Testing
- rapamycin
- Where
- 17 sites in United States, Australia and 7 more
- Volunteers
- 107 people
- Sponsor
- Dermatology Specialties Limited Partnership
Relapsing Remitting Multiple Sclerosis
Lesion Load and Location in Relation to Cognition, Fatigue and Physical Disability in RRMS
In relapsing remitting multiple sclerosis (RRMS) the relationship between cognitive impairment (CI), fatigue and physical disability with white matter lesion load (WM-LL), location among other volumetric measures using automated…
- Trial name
- NCT05604092
- Testing
- VolBrain, a fully automated platform to generate the volumetric data (lesion count, volume and location as well as different atrophy measures), Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Multiple Sclerosis
Biomechanical Characterization of the Locomotion in Multiple Sclerosis Patients
Multiple sclerosis (MS) is an inflammatory chronic disease of the central nervous system. Patients are suffering from balance and gait impairments at the early stage of the disease.
- Trial name
- WALKING-SEP (NCT03756142)
- Testing
- Motion Analysis
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Relapsing Remitting Multiple Sclerosis
A Study to Evaluate the Safety and Effectiveness of Novantrone Therapy Followed by Copaxone for Multiple Sclerosis.
It is thought that treating multiple sclerosis with Novantrone for a short period of time prior to treatment with Copaxone may enhance the onset effect of Copaxone.
- Trial name
- NCT00203073
- Testing
- glatiramer acetate 20 mg, glatiramer acetate 20 mg, with mitoxantrone
- Volunteers
- 40 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Relapsing Remitting Multiple Sclerosis
Intermittent Fasting in Multiple Sclerosis
This is a randomized controlled trial that will test the effects of intermittent fasting (IF) in subjects with relapsing-remitting MS (RRMS).
- Trial name
- IFMS (NCT03539094)
- Testing
- Intermittent fasting
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Washington University School of Medicine
Tuberous Sclerosis, STXBP1 Encephalopathy With Epilepsy
Gait in Rare Diseases
The aim of this pilot study is to explore whether the knowledge and experience gained during the T-GaiD project (Treatment of Gait Disorders in Dravet Syndrome - NCT03857451) can be transferred to other populations with similar…
- Trial name
- GAGA (NCT05161494)
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Universiteit Antwerpen
Herpesviridae Infection, HTLV-I Infection
Assessment of Patients With Multiple Sclerosis (MS)
Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition.
- Conditions
- Herpesviridae Infection, HTLV-I Infection, Multiple Sclerosis, Tropical Spastic Paraparesis
- Trial name
- NCT00001156
- Where
- United States
- Volunteers
- 1,388 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
Validity and Reliability of the Dual-task Questionnaire
It is important to increase the independence of Multiple Sclerosis (MS) patients in activities of daily living. Almost all activities of daily living require managing many activities at the same time.
- Trial name
- NCT05188937
- Testing
- validity and reliability study
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gazi University
Low Grade Glioma of Brain, Multiple Sclerosis
Early Detection and Paramedical Care of Sexual Difficulties in Nervous System Diseases: Example of Multiple Sclerosis and Brain Tumors (NEUROSEX)
This study aim to ensure that the implementation of a paramedical screening program and counseling in sexual health of patients with neurological pathologies (low-grade gliomas and Multiple Sclerosis) improves their sexual health.
- Conditions
- Low Grade Glioma of Brain, Multiple Sclerosis, Sexual Dysfunctions
- Trial name
- NEUROSEX (NCT03154801)
- Testing
- Paramedical care
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis, Sexual Dysfunction
Multiple Sclerosis Intimacy and Sexuality Questionnaire
Aims: This study aimed to psychometrically evaluate the Turkish version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) in women with MS. Methods: The study included 130 women with MS.
- Conditions
- Multiple Sclerosis, Sexual Dysfunction, Questionnaires
- Trial name
- NCT05374031
- Testing
- descriptive study
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bozok University
Multiple Sclerosis (MS) - Relapsing-remitting, Upper Extremity Dysfunction
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people…
- Trial name
- NCT07376772
- Testing
- wearable focal vibration therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Multiple Sclerosis
A Study to Evaluate the Preliminary Efficacy Pharmacokinetics and Immunogenicity of BMS-188667 Administered to Subjects With Relapsing-remitting Multiple Sclerosis
The purpose of this study is to determine whether BMS-188667 will decrease multiple sclerosis disease activity on MRI examinations, as well as decrease the rate of clinical MS exacerbations, compared to placebo
- Trial name
- NCT00035529
- Testing
- BMS 188667 (Abatacept)
- Where
- 10 sites in United States
- Sponsor
- Bristol-Myers Squibb
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