Clinical trials: multiple sclerosis
Multiple Sclerosis
Duloxetine for Multiple Sclerosis Pain
This study is designed to primarily assess the efficacy and safety of duloxetine 60-120 mg once daily (QD) compared with placebo on the reduction of pain severity in participants with central neuropathic pain due to Multiple…
- Trial name
- NCT00755807
- Testing
- Duloxetine Hydrochloride (HCI)
- Where
- 22 sites in United States, Belgium and 2 more
- Volunteers
- 239 people
- Sponsor
- Eli Lilly and Company
Relapsing Forms of Multiple Sclerosis
Long-term Safety and Tolerability of 0.5 mg Fingolimod in Patients With Relapsing Forms of Multiple Sclerosis
The purpose of this study was to collect long-term safety and tolerability, long-term efficacy, and health outcome data in all patients currently ongoing in the fingolimod multiple sclerosis clinical development program.
- Trial name
- NCT01201356
- Testing
- Fingolimod
- Where
- 458 sites in United States, Argentina and 36 more
- Volunteers
- 4,125 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Improving Hand Use in Multiple Sclerosis
This study will compare two different kinds of physical therapy to improve use of the hands in individuals with multiple sclerosis (MS).
- Trial name
- NCT01081275
- Testing
- CI Therapy, CAM treatments
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Multiple Sclerosis Society
Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis (RRMS)
Treatment of Memory Retrieval Impairments in MS With HDtDCS to the LIFG in a Placebo Controlled Trial
The purpose of the study is to test whether low-level electric stimulation, called High Definition transcranial Direct Current Stimulation (HDtDCS), on the part of the brain (i.e., left inferior frontal gyrus) thought to aid in…
- Trial name
- MS-LIFG-HDtDCS (NCT07914257)
- Testing
- High Definition transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas at Dallas
Multiple Sclerosis
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration…
- Trial name
- FREVIVA (NCT06141486)
- Testing
- Frexalimab, MRI contrast-enhancing agents
- Where
- 311 sites in United States, Argentina and 25 more
- Volunteers
- 943 people
- Sponsor
- Sanofi
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
The purpose of this research is to support the clinical value of the Cionic Neural Sleeve for individuals diagnosed with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
- Trial name
- NCT05964829
- Testing
- Cionic Neural Sleeve NS-100, Walking Program
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Cionic, Inc.
Physical Therapy
Respiratory Functions, Trunk Control and Mobility Evaluation in Multiple Sclerosis
Respiratory functions and body control are affected in patients with multiple sclerosis (MS). Because of this effect, the dependency of individuals increases in daily living activities and their quality of life decreases.
- Trial name
- NCT03826095
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Secondary Progressive Multiple Sclerosis
MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
Multiple sclerosis (MS) is a disabling and progressive neurological disease that affects approximately 100,000 people in the UK.
- Trial name
- MS-SMART (NCT01910259)
- Testing
- Amiloride, Riluzole, Fluoxetine
- Where
- 13 sites in United Kingdom
- Volunteers
- 445 people
- Sponsor
- University College, London
Multiple Sclerosis
Levetiracetam in Central Pain in Multiple Sclerosis(MS)
Multiple sclerosis is often associated with pain. There is no standard treatment of this type of pain. Levetiracetam is a new anticonvulsant and it is the hypothesis that it could relieve central pain in multiple sclerosis.
- Trial name
- NCT00423527
- Testing
- levetiracetam
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Relapsing Remitting Multiple Sclerosis
A Study to Evaluate the Long Term Safety and Effectiveness of Novantrone Therapy Followed by Copaxone Treatment for Multiple Sclerosis
It is thought that treating Multiple Sclerosis with Novantrone for a short period of time prior to treatment with Copaxone may enhance the onset effect of Copaxone.
- Trial name
- NCT00203086
- Volunteers
- 30 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple Sclerosis
Effect of Combined Exercise Training in Patients With Multiple Sclerosis
The aim of this clinical trial is exercise in sarcopenic MS patients to demonstrate the effectiveness of education. The main questions it aims to answer are: -Can exercise training make a change in muscle thickness in sarcopenic…
- Trial name
- NCT06595394
- Testing
- Exercise, Home program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Uskudar University
Multiple Sclerosis, Relapsing-Remitting
Assessing the HERV-W Env ANtagonist GNbAC1 for Evaluation in an Open Label Long-term Safety Study in Patients With Multiple Sclerosis
The humanised IgG4 monoclonal antibody GNbAC1 targets the envelope protein (Env) of the human endogenous multiple sclerosis-associated retrovirus (HERV-W MSRV), which may play a critical role in multiple sclerosis.
- Trial name
- ANGEL-MS (NCT03239860)
- Testing
- GNbAC1 Monoclonal Antibody
- Where
- 12 sites in Bulgaria, Croatia and 10 more
- Volunteers
- 220 people
- Sponsor
- GeNeuro SA
Fatigue
Ginseng in Treatment of Fatigue in Multiple Sclerosis
The purpose of this study was to evaluate the efficacy and safety of Ginseng in treatment of fatigue and Quality of Life of MS patients.
- Trial name
- NCT01712373
- Testing
- Ginseng
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Fibromyalgia, Chronic Fatigue Syndrome
Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called [Zr-89]oxine to track the location of white blood cells (also called leukocytes) in the…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03807973
- Testing
- [Zr-89]Oxine-labeled leukocytes PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
Effectiveness of Acupuncture Treatment Applied in Addition to the Rehabilitation Program in Multiple Sclerosis Patients
The purpose of the study is to assess the effect of acupuncture treatment combinated with conventional rehabilitation methods on gait, fatigue, quality of life and bladder functions in patients with multiple sclerosis
- Trial name
- NCT06178029
- Testing
- Acupuncture, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Multiple Sclerosis, Acute Relapsing
An Intravenous Infusion Study of rHIgM22 in Patients With Multiple Sclerosis Immediately Following a Relapse
This is a Phase 1, multi-center, double-blind, randomized, placebo-controlled, dose-escalation study in subjects with relapsing Multiple Sclerosis (MS).
- Trial name
- NCT02398461
- Testing
- rHIgM22
- Where
- 12 sites in United States
- Volunteers
- 27 people
- Sponsor
- Acorda Therapeutics
Multiple Sclerosis
Capillary Dysfunction and CD46-immunoreceptor (CD46) Type in MS
This project aims to contribute knowledge to early MS disease mechanisms at the brain-blood interface using a combined immunological and neuroimaging approach.
- Trial name
- NCT03906370
- Testing
- Diagnostic criteria for MS
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- University of Aarhus
Multiple Sclerosis
Aerobic Exercise in Persons With Multiple Sclerosis With Restless Legs Syndrome
In this studly, the effects of an 12-week aerobic exercise training in persons with multiple sclerosis with restless legs syndrome will be investigated.
- Trial name
- NCT05402956
- Testing
- Aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dokuz Eylul University
Multiple Sclerosis
Dynamic Balance Training in Multiple Sclerosis
This study will test a new technique for improving balance while walking in people with multiple sclerosis (MS). The technique focuses on having people with MS safely practice walking on simulated, uneven terrain that challenges…
- Trial name
- NCT04719494
- Testing
- Dynamic balance walking training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marquette University
Multiple Sclerosis
A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers
Primary Objective: To assess the pharmacokinetic (PK) parameters of teriflunomide after a single oral dose of 14 mg administration in Chinese healthy subjects Secondary Objective: To assess the safety and tolerability after a…
- Trial name
- NCT02046629
- Testing
- Teriflunomide HMR1726, cholestyramine
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sanofi
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