Clinical trials: multiple sclerosis
Multiple Sclerosis
The Efficacy, Safety, and Tolerability of Laquinimod in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)
This is a multinational, multicenter, randomized, double-blind, parallel-group, placebo-controlled study followed by active treatment, to evaluate the efficacy, safety and tolerability of two doses of oral administration of…
- Trial name
- CONCERTO (NCT01707992)
- Testing
- Laquinimod
- Where
- 284 sites in United States, Austria and 28 more
- Volunteers
- 2,199 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple Sclerosis
Interferon ß-1b Treatment by Cyclical Administration
The therapy with Interferon-ß-1b reduces the inflammatory component of multiple sclerosis with positive effects on the disease course. The 8 MUI dose at alternate days is kept constant for years.
- Trial name
- NCT00270816
- Testing
- Interferon-ß-1b, Interferon ß-1b
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- S. Andrea Hospital
Multiple Sclerosis, Fatigue
Aspirin for Treatment of Multiple Sclerosis-Related Fatigue
The purpose of this study is to determine whether aspirin is effective for treatment of fatigue caused by multiple sclerosis (MS).
- Trial name
- NCT00467584
- Testing
- High Dose Aspirin (1300 mg/day), Low Dose Aspirin (162 mg/day)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Central Nervous System Disease, Multiple Sclerosis
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system.
- Trial name
- NCT00794352
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Relapsing-remitting Multiple Sclerosis
Safety, Tolerability, Efficacy and Optimal Dose Finding Study of BAF312 in Patients With Relapsing-remitting Multiple Sclerosis
The purpose of this study was to determine the dose-response curve for the MRI-based efficacy of BAF312 compared with placebo in patients with Relapsing-Remitting Multiple Sclerosis (RRMS), and to characterize its safety and…
- Trial name
- NCT00879658
- Testing
- BAF312
- Where
- 72 sites in United States, Canada and 10 more
- Volunteers
- 297 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers, Multiple Sclerosis
Safety, Pharmacokinetics and Pharmacodynamics Study With 2B3-201 in Healthy Subjects and Multiple Sclerosis(MS) Patients
In this first in human study the aim is to assess the safety, pharmacokinetics and pharmacodynamics of 2B3-201 in a randomized, first in human, double-blind, placebo- and active comparator- controlled 3-way crossover study in 18…
- Trial name
- NCT02048358
- Testing
- 2B3-201, Methylprednisolone hemisuccinate
- Where
- 2 sites in Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- BBB-Therapeutics B.V.
Multiple Sclerosis
Resistance Training and Amino Pyridine in Multiple Sclerosis
Prolonged-release fampridine (SR-fampridine) can improving walking capacity in approximately 40% of MS patients suffering from this by overcoming partly or total conduction block due to demyelination.
- Trial name
- RETRAP (NCT02143167)
- Testing
- SR-fampridine
- Where
- 4 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- University of Southern Denmark
Multiple Sclerosis
Relationship of Position Sense With Gait and Balance in Patients With Multiple Sclerosis
Balance and gait disturbances are among the most common problems in patients with Multiple Sclerosis (MS). There is evidence of decreased foot sole sensation in MS patients.
- Trial name
- NCT04547400
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis
Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Amyloid PET-CT
The goal of this clinical trial study is to evaluate the presence of relationships between PET and MRI images indicative of chronic inflammatory activity (smoldering plaques), apparent absence of inflammatory activity (silent…
- Trial name
- NCT05783934
- Testing
- 18F-florbetaben PET/CT
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Traumatic Brain Injury, Multiple Sclerosis
Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging
This study will test a new MRI sequence that measures cerebral blood flow (CBF). Because this technique for measuring CBF is new, there is little information on what the normal values for different regions of the brain should be.
- Conditions
- Traumatic Brain Injury, Multiple Sclerosis, Alzheimer's Disease, Tumor
- Trial name
- NCT02767609
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Multiple Sclerosis, Weakness
Effects of the Cross-Training in Patients With Multiple Sclerosis
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer…
- Conditions
- Multiple Sclerosis, Weakness, Fatigue
- Trial name
- CTSM (NCT02010398)
- Testing
- Cross-Training healthy subjects, Cross-Training multiple sclerosis, Standard-training multiple sclerosis
- Where
- 3 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Optic Neuritis, Neuromyelitis Optica
Optic Neuritis Differential Diagnosis Study
Background: Optic neuritis is a frequent cause of vision loss encountered by ophthalmologists in the Caribbean. The diagnosis is made on clinical grounds.
- Conditions
- Optic Neuritis, Neuromyelitis Optica, Multiple Sclerosis
- Trial name
- ONDDS (NCT03370965)
- Testing
- Neuro-ophtalmology examination
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital Center of Martinique
Multiple Sclerosis
Open, Multicentric, Prospective, Quality of Life Study in Multiple Sclerosis Patients
To evaluate the evolution of the impact on daily life activities over the first 12 months following the introduction of interferon beta-1b treatment in patients presenting RRMS or patients at high risk of developing Multiple…
- Trial name
- NCT00928967
- Testing
- Interferon beta-1b, (Betaseron BAY86-5046)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Bayer
Multiple Sclerosis
The Effect of Self Acupressure in Patients With Multiple Sclerosis
Patients with MS use non-pharmacological methods as well as pharmacological methods in the treatment of their symptoms. Acupuncture, acupressure, aquatherapy, reflexology and aromatherapy are also complementary and integrated…
- Trial name
- NCT06600971
- Testing
- acupressure application
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Multiple Sclerosis
A Study to Evaluate the Efficacy of Sativex in Relieving Symptoms of Spasticity Due to Multiple Sclerosis
The purpose of this study was to assess the efficacy of Sativex in relieving symptoms of spasticity in multiple sclerosis
- Trial name
- NCT01599234
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 337 people
- Sponsor
- Jazz Pharmaceuticals
Multiple Sclerosis
Does Microglial Activation Promote Lesion Growth and Progression Among Multiple Sclerosis Patients
The purpose of this study is to assess whether increased microglial activation (measured using TSPO-PET) at lesion rim is associated with more rapid lesion growth during 10 year follow up.
- Trial name
- FUP-MS (NCT04625049)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Relapsing Remitting Multiple Sclerosis
A Study to Evaluate 2 Doses Of Oral Administration Of Laquinimod Compared to Interferon ß-1a Administered by Injection in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)
The purpose of the study is to assess the efficacy, safety, and tolerability of two doses of laquinimod compared to Avonex®
- Trial name
- LIBRETTO (NCT01975298)
- Testing
- Laquinimod, Avonex®
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple Sclerosis
A Retrospective Study to Understand the Clinical Management of Subjects With Multiple Sclerosis at a Site in Taiwan Over the Last 10 Years
This is an observational, non comparative, non-randomised, open-label, retrospective, single centre study planned to collect the data of subjects diagnosed with multiple sclerosis (MS) as per Poser or McDonald criteria between…
- Trial name
- NCT01084798
- Where
- Taiwan
- Volunteers
- 123 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis
CONNECT Trial of eSupport Online Health-coach Moderated Support Groups for Multiple Sclerosis
Within-subject waitlist-control group design trial of eSupport health-coach moderated online support group participation to address mental health needs in persons with multiple sclerosis (PwMS) from historically underrepresented…
- Trial name
- CONNECT (NCT04943887)
- Testing
- eSupport Health Weekly Group Sessions for PwMS
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- eSupport Health
Prediction of Disease Progression, Multiple Sclerosis
Disease Progression in ms
Demographic and clinical data will be obtained from people with MS. Based on this data, the progression of the disease will be predicted with artificial intelligence.
- Trial name
- NCT07292116
- Volunteers
- 53 people
- Sponsor
- Hüseyin Bektaş
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