Clinical trials: multiple sclerosis
Relapsing Remitting Multiple Sclerosis
Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms
The investigators' overall hypothesis is that appearance or worsening of relapsing-remitting multiple sclerosis (RR-MS) symptoms are affected by various factors including stress, hormonal cycles, illness and missed medications.
- Trial name
- NCT00919217
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Louisville
Multiple Sclerosis
Unraveling Early Walking Dysfunction in Non-disabled MS People: Assessment and Potential Therapeutic Interventions
The aim of the study is to set up a pilot study to investigate the effects of treadmill training in preventing the onset and worsening of walking impairments, balance deficits and fatigue.
- Trial name
- NCT03492450
- Testing
- Treadmill training
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis
The goal of this pilot study is to determine whether fecal microbial transplant (FMT) has the potential to be an effective, safe and tolerable therapy for the treatment of multiple sclerosis (MS).
- Trial name
- NCT04096443
- Testing
- Fecal microbial transplant (FMT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Griffin Hospital
Multiple Sclerosis
Detection of Pattern of Some Unusual Signs and Symptoms of Multiple Sclerosis
Each Multiple Sclerosis patient will be submitted to Cognitive Abilities Screening Instrument (CASI), Expanded Disability Status Scale, Epowrth Sleeping Scale(ESS),Fatigue Severity Scale(FSS), Hamilton Depression Rating Scale…
- Trial name
- NCT04100343
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
SPINCOMS Biomarker Study
To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS) diseases.
- Trial name
- SPINCOMS (NCT04496830)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Intensity Depended Impacts on Cognitive Functions in Persons With Multiple Sclerosis - a Pilot Study
Multiple Sclerosis (MS) is a chronic autoimmune disease where lymphocytes inflict damage to the axons and myelin sheaths of the central nervous system.
- Trial name
- NCT02408367
- Testing
- Exercise, Relaxation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Jens Bansi
Multiple Sclerosis
The Effect of Levetiracetam (Keppra) on the Treatment of Tremor in Multiple Sclerosis
We are carrying out this study to determine whether Keppra (a drug usually used to treat epilepsy) is an effective treatment for tremor in patients with Multiple Sclerosis.
- Trial name
- NCT00430599
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Amyotrophic Lateral Sclerosis
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS
A Phase 2b/3 multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety and tolerability of MN-166 given to ALS participants for 12 months followed by a 6-month open-label…
- Trial name
- COMBAT-ALS (NCT04057898)
- Testing
- MN-166
- Where
- 16 sites in United States, Canada
- Volunteers
- 234 people
- Sponsor
- MediciNova
Multiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant
ATLG Levels in Autologous HSCT for Multiple Sclerosis
This is a prospective, observational, biological, multicenter study to investigate IR profile, ATLG dynamics, main HSCT and disease outcomes in MS.
- Conditions
- Multiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant, ATLG
- Trial name
- ATLG-MS (NCT07635693)
- Testing
- ATLG administration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ciceri Fabio
Multiple Sclerosis, Optic Neuritis
Longitudinal Optic Neuritis Study (LONS)
To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis.
- Trial name
- NCT00000147
- Testing
- Methylprednisolone, Prednisone
- Where
- 15 sites in United States
- Sponsor
- National Eye Institute (NEI)
Multiple Sclerosis, Treatment Adherence
Semi-inmersive Virtual Reality on Upper Limb in Multiple Sclerosis
Video games based on VR technology are emerging as valid tools used in neurorehabilitation for patients with neurological disorders, and as a low cost and easily accepted adjunct to traditional therapy.
- Conditions
- Multiple Sclerosis, Treatment Adherence, Upper Extremity Paresis
- Trial name
- NCT04171908
- Testing
- Conventional therapy, semi-inversive tech
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Trigeminal Neuralgia, Multiple Sclerosis
A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life and Reduce Complications
The aim of this study is to evaluate prospectively the feasibility and impact of personalised gamma knife radiosurgery treatment protocol versus current standard protocol for people with idiopathic or Multiple Sclerosis-related…
- Conditions
- Trigeminal Neuralgia, Multiple Sclerosis, Pain
- Trial name
- NCT04117035
- Testing
- Gamma Knife Radiosurgery (GKRS) personalised procedure, GKRS standard care
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Leeds
Multiple Sclerosis, Overactive Bladder
PTNS for Female Patients Suffering From Multiple Sclerosis
This is a pilot, single blind, randomized, sham-controlled trial to assess the benefit of Percutaneous Tibial Nerve Stimulation (PTNS) in treating bladder overactivity (OAB) symptoms in multiple sclerosis (MS) patients.
- Trial name
- PTNS-MS (NCT05422625)
- Testing
- PTNS Treatment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Interstitial Lung Disease with Progressive Fibrotic Phenotype in Diseases Classified Elsewhere, Systemic Sclerosis Pulmonary
Home Based Clinical Management of Interstitial Lung Disease in Systemic Rheumatic Diseases
The RMD-mILDer trial is a home monitoring strategy trial aiming to improve management of interstitial lung disease related to rheumatic diseases applying eHealth technology.
- Conditions
- Interstitial Lung Disease with Progressive Fibrotic Phenotype in Diseases Classified Elsewhere, Systemic Sclerosis Pulmonary, Dermatomyositis, Rheumatoid Arthritis
- Trial name
- RMD-mILDer (NCT06732674)
- Testing
- A home monitoring strategy with event driven management
- Where
- Norway
- Volunteers
- 218 people
- Sponsor
- Oslo University Hospital
Multiple Sclerosis (MS)
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
- Trial name
- NEOS (NCT04926818)
- Testing
- Fingolimod, Ofatumumab, Siponimod
- Where
- 51 sites in United States, Argentina and 23 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Expanded Access to Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis
To give expanded access to intrathecal autologous MSC-NP treatment to patients with progressive MS who do not meet the inclusion/exclusion criteria of our Phase II stem cell trial.
- Trial name
- NCT03822858
- Testing
- Intrathecal MSC-NP injection
- Where
- United States
- Sponsor
- Tisch Multiple Sclerosis Research Center of New York
Multiple Sclerosis
Teriflunomide Male Transmission Study
It is known that teriflunomide, a treatment for relapsing forms of multiple sclerosis, can be found in low concentrations in semen.
- Trial name
- NCT02679885
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Griffin Hospital
Scleroderma, Systemic
Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis
GSK2330811 is a humanized monoclonal antibody which is in development for systemic sclerosis (SSc), a rare autoimmune disease with high morbidity and mortality.
- Trial name
- NCT03041025
- Testing
- GSK2330811
- Where
- 14 sites in United States, Canada and 2 more
- Volunteers
- 35 people
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
An Extension Study of the Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing Multiple Sclerosis
This study was an extension study of NCT00537082. This study was designed to evaluate the efficacy and safety of long-term administration of 0.5 mg or 1.25 mg of fingolimod (FTY720) to relapsing multiple sclerosis.
- Trial name
- NCT00670449
- Testing
- Fingolimod
- Where
- 20 sites in Japan
- Volunteers
- 143 people
- Sponsor
- Novartis
Multiple Sclerosis
A Multi-Site, Open-Label Extension Trial of Oral RPC1063 in Relapsing Multiple Sclerosis
The purpose of the trial is to determine the safety and efficacy of RPC1063 in patients with relapsing multiple sclerosis.
- Trial name
- NCT02576717
- Testing
- RPC1063
- Where
- 175 sites in United States, Belarus and 24 more
- Volunteers
- 2,494 people
- Sponsor
- Celgene
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