Clinical trials: multiple sclerosis
Multiple Sclerosis
A Pilot Study Assessing the Impact of Gilenya Therapy on Bone Density Change in Relapsing Forms of Multiple Sclerosis
The purpose of this study is to assess whether Multiple Sclerosis patients treated with Gilenya show a beneficial change over time in bone mass density and bone turnover markers as compared to matched controls treated with…
- Trial name
- MS-BMD (NCT01811290)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Simnad, Virginia, M.D.
Secondary-progressive Multiple Sclerosis
Safety Study of Human Neural Stem Cells Injections for Secondary Progressive Multiple Sclerosis Patients
This will be a phase I, open, multicenter, international study performed by 3 participating centres across two countries (Italy and Switzerland).
- Trial name
- NSC-SPMS (NCT03282760)
- Testing
- Human Neural Stem Cells
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 24 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
MS CHRONIC PROGRESSIVE
Automated EDSS Score Calculation by Smartphone Application
The EDSS score is the reference tool for rating disability in patients with multiple sclerosis. It is used in both daily monitoring and clinical research studies.
- Trial name
- Easy EDSS (NCT03586635)
- Testing
- neurological exam
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
Telerehabilitation vs Supervised Exercises in MS
Multiple sclerosis (MS) is a complex neurodegenerative autoimmune disease. People with MS (PwMS) have low quality of life (QoL) and activities of daily living (ADL). Exercise is a safe and effective rehabilitation tool for PwMS.
- Trial name
- NCT04413682
- Testing
- Structured Supervised Exercise, Structured telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS
The purpose of this study is to examine the effect of treatment with fampridine in patients with secondary progressive MS (SPMS) or primary progressive MS (PPMS) with upper limb dysfunction (as defined by a 9-HPT time of between…
- Trial name
- NCT02208050
- Testing
- Fampridine
- Where
- 2 sites in Ireland
- Volunteers
- 64 people
- Sponsor
- University College Dublin
Multiple Sclerosis, Cognitive Decline
Digital Cognition in Multiple Sclerosis
A DIGITAL THERAPEUTIC TO IMPROVE THINKING IN MULTIPLE SCLEROSIS WHO: 65 participants with a confirmed diagnosis of Multiple Sclerosis (MS) WHY: Purpose of the study is to compare the effect of 2 tablet-based brain training…
- Trial name
- DigCog (NCT03569618)
- Testing
- Tablet-based Game
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
Lorraine Registry of Multiple Sclerosis
The RelSEP aims to register exhaustively every new case of multiple sclerosis (MS) occuring in Lorraine a French region, and follow up on them for an indefinite duration, registering disease evolution and intercurrent events.
- Trial name
- RelSEP (NCT02883335)
- Testing
- Observational registry
- Where
- France
- Volunteers
- 6,000 people
- Sponsor
- Central Hospital, Nancy, France
Multiple Sclerosis
Evaluation of Early Changes Visible to the Diffusion MRI in Response to Two Years of Treatment With Tysabri in Patients With Multiple Sclerosis
Through this phase IV study, multicenter prospective exploratory, uncontrolled, the investigators propose to identify MRI predictive factors of treatment response, using diffusion MRI sequences, in addition to conventional…
- Trial name
- TYSADIFF (NCT02904876)
- Testing
- Diffusion Magnetic Resonance Imaging at 6 months
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Sclerosis
High Intensity Interval Gait Training in Multiple Sclerosis
Over 90% of persons with MS (pwMS) complain of difficulty with walking. High intensity interval gait training (HIIGT), where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve…
- Trial name
- NCT05560880
- Testing
- High Intensity Interval Gait training, Moderate Intensity Interval gait training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Multiple Sclerosis
Evaluate Early Glatiramer Acetate Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis of Subjects Presenting With Clinically Isolated Syndrome
The primary objective is to assess the effect of treatment with glatiramer acetate (GA) compared to placebo on the time to conversion to CDMS, as determined by Poser criteria (the occurrence of the second clinical attack) during…
- Trial name
- PreCISe (NCT00666224)
- Testing
- Glatiramer Acetate (DB), Glatiramer Acetate (OL)
- Volunteers
- 481 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Relapsing Multiple Sclerosis, Multiple Sclerosis
Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS)
The main aim and overall objective of the study is to assess whether rituximab is non-inferior to cladribine for the treatment of relapsing MS.
- Trial name
- NOR-MS (NCT04121403)
- Testing
- Rituximab, Cladribine
- Where
- 11 sites in Norway
- Volunteers
- 267 people
- Sponsor
- Oslo University Hospital
Multiple Sclerosis
Reduced-intensity Immunoablation and Autologous Hematopoietic Stem Cell Transplantation (AHSCT) for Multiple Sclerosis
This is a patient-sponsored study that evaluates the safety and efficacy of reduced-intensity immunoablation followed by a single dose autologous hematopoetic stem cell transplantation in patients diagnosed with multiple…
- Trial name
- NCT03113162
- Testing
- Autologous Hematopoietic Stem Cell, BEAM Regimen
- Where
- Philippines
- Volunteers
- 15 people
- Sponsor
- Makati Medical Center
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis, Clinically Isolated Syndrome
Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)
Patients with an acute exacerbation of Relapsing-Remitting Multiple Sclerosis or with Clinically Isolated Syndrome receive either one single infusion of Nanocort or three daily infusions of SoluMedrol.
- Trial name
- NCT01039103
- Testing
- PEG-liposomal prednisolone sodium phosphate, Methylprednisolone
- Where
- 8 sites in Belgium, Germany and 1 more
- Volunteers
- 15 people
- Sponsor
- Lakefront Biotherapeutics NV
Relapsing Remitting Multiple Sclerosis
Evaluate Safety/Tolerability in Portuguese Participants With RRMS Transitioning From Current Therapy
The primary objective of the study is to evaluate safety and tolerability as defined by the frequency of the adverse events (AEs) of flu-like symptoms (FLS) [chills, pyrexia, myalgia, and asthenia], injection site reactions…
- Trial name
- PLENO (NCT03177083)
- Testing
- peginterferon beta-1a, interferon beta-1a, interferon beta-1b
- Where
- 15 sites in Portugal
- Volunteers
- 80 people
- Sponsor
- Biogen
Multiple Sclerosis
Observational Study on Multiple Sclerosis
This is a multicentre observational study which involves 43 of the major Italian centres that treat MS. The duration expected for the study participation of each subject was exclusively the necessary one for the screening visit…
- Trial name
- NCT04133779
- Testing
- neurological examination, Kurtzke EDSS, Barthel scale, ecocolor-Doppler, neurological evaluation, ecocolor-Doppler, medical history, vital signs, ecocolor-Doppler
- Volunteers
- 1,767 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Multiple Sclerosis
Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis
The project will involve a within-subjects, repeated-measures research design. Participants will initially be screened for relevant inclusion/exclusion criteria for maximizing safety of participating in an exercise study.
- Trial name
- PRIMERS (NCT06233370)
- Testing
- Moderate intensity walking exercise
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
The Multiple Sclerosis Continuous Quality Improvement (MSCQI) Collaborative
To establish the first systems level continuous quality improvement (CQI) collaborative for multiple sclerosis (MS) in the United States, to conduct benchmarking analyses and assessments of geographic variation in MS care quality…
- Trial name
- NCT03480854
- Testing
- Quality Improvement
- Where
- 4 sites in United States
- Volunteers
- 694 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ataxia, Multiple Sclerosis
Teleassessment in Ataxic Multiple Sclerosis
Our aim is to compare ICARS and SARA scores with face-to-face and tele-assessment methods in ataxic multiple sclerosis patients.
- Trial name
- NCT05585541
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Multiple Sclerosis
A Clinical Trial Evaluating the Safety and Efficacy of Myelin-peptide Loaded tolDC as Treatment for MS
The investigators propose to design and conduct a phase II clinical trial to treat patients with multiple sclerosis (MS) by vaccination with tolerogenic dendtritic cells (tolDC), generated using Good Manufacturing Practices…
- Trial name
- MS-tolDC_2 (NCT06715605)
- Testing
- tolerogenic dendritic cells (tolDC), Standard-of-care
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Multiple Sclerosis
Assessing the Induction of Long-term Immune Regulation Following Treatment With Lemtrada® (Alemtuzumab).
In this study the investigators wish to test the hypothesis that treatment with Lemtrada is associated with alterations in immune homeostasis in favor of multiple regulatory leukocyte populations which persist long after…
- Trial name
- NCT03647722
- Testing
- Assessment of leukocyte function.
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Southern California