Clinical trials: multiple sclerosis
Relapsing Forms of Multiple Sclerosis
Time and Motion Study for Ocrelizumab and Ofatumumab Administration in Relapsing Multiple Sclerosis
This is an observational cross-sectional study of Ocrelizumab or Ofatumumab administrations for Relapsing forms of Multiple Sclerosis (RMS) in selected sites in the US, the UK and Australia.
- Trial name
- TIMIOS (NCT04676555)
- Testing
- Ocrelizumab, Ofatumumab
- Where
- 2 sites in United States, Australia
- Volunteers
- 2 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Calorie Restriction in Multiple Sclerosis Patients
The investigators hypothesize that adipokine (soluble molecules produced by the adipose tissue) levels are altered in MS compared to control subjects.
- Trial name
- NCT02411838
- Testing
- Calorie restriction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Resilience in Young Adults Newly Diagnosed With Multiple Sclerosis
This study aims to fill the gap of knowledge on the biopsychosocial (BPS) characteristics and resilience of young adults newly diagnosed with Multiple Sclerosis, to evaluate the relationship among these variables, and to develop…
- Trial name
- BPS-ARMS (NCT03825055)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Universita di Verona
Spinal Cord Injury, Stroke (CVA) or Transient Ischemic Attack
Understanding and Enhancing Human Health and Movement
By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation…
- Conditions
- Spinal Cord Injury, Stroke (CVA) or Transient Ischemic Attack, Multiple Sclerosis
- Trial name
- NCT07738978
- Testing
- Neural Prosthesis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Louis Stokes VA Medical Center
Multiple Sclerosis, Clinically Isolated Syndrome
Immunoadsorption vs. Plasmapheresis in the Escalation Therapy of Relapse in Multiple Sclerosis
This observational study investigates the efficacy and safety of immunoadsorption versus plasmapheresis in 60 patients with relapse in Multiple Sclerosis and Clinically isolated syndrome who do not fully recover after a high…
- Trial name
- NCT02671682
- Testing
- Immunoadsorption, Plasmapheresis
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Albert Christian Ludolph, Prof.
Multiple Sclerosis
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and results in a wide range of signs and symptoms including physical and cognitive problems.
- Trial name
- NCT02580435
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Tuberous Sclerosis Complex Associated Neuropsychiatric Disease
A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex
The purpose of this study is to investigate behavioral and other co-occurring outcomes with EPID(I/Y)OLEX as an add-on therapy in participants aged 1 to 65 years with tuberous sclerosis complex (TSC) who experience seizures.
- Trial name
- EpiCom (NCT05864846)
- Testing
- Cannabidiol Oral Solution [Epidiolex]
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 79 people
- Sponsor
- Jazz Pharmaceuticals
Multiple Sclerosis
Immunogenicity and Safety Study of Serum-Free Avonex
To evaluate the immunogenicity of a serum-free pre-formulated solution of Avonex when given to interferon beta naive patients with relapsing/remitting multiple sclerosis.
- Trial name
- NCT00912860
- Testing
- Interferon beta-1a
- Volunteers
- 155 people
- Sponsor
- Biogen
Multiple Sclerosis
Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years (STOP-I-SEP)
Further controlled and randomized prospective studies in Multiple sclerosis, analyzing the potential impact of treatment discontinuation on disability progression, focal disease activity and quality of life are needed.
- Trial name
- STOP-I-SEP (NCT03653273)
- Testing
- DMT withdrawal, DMT continuation
- Where
- 27 sites in France
- Volunteers
- 250 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Implementing Physical Activity Guidelines for Adults With MS
The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities.
- Trial name
- NCT02100020
- Testing
- Direct Referral to physical activity
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- McMaster University
Parkinson's Disease, Multiple Sclerosis
Expiratory Muscle Training for Persons With Neurodegenerative Disease
Respiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis.
- Trial name
- EMST (NCT00856518)
- Testing
- EMST
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Long-term, Open-label, Multicenter Study Assessing Long-term Cardiovascular Risks
This study will evaluate if patients who had a serious cardiovascular event upon initiation of fingolimod are at risk to delevop long term other cardiovascular events
- Trial name
- NCT02232061
- Testing
- Fingolimod
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 6 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Meeting an Unmet Need in Multiple Sclerosis
The primary objectives of this study is to examine the efficacy of the Unified Protocol in decreasing depression and anxiety among individuals with MS and the secondary outcomes (e.g., improved well-being, QOL, coping, etc.) that…
- Trial name
- NCT05953519
- Testing
- Unified Protocol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Evaluation of the Safety, Tolerability, and Efficacy of Orally Administered PTL201 in MS Patients With Spasticity-related Symptoms
To evaluate the safety and tolerability of oral administration of PTL201 for relief of spasticity-related symptoms in 70 MS patients and to evaluate the efficacy of oral administration of PTL201 in relief of spasticity-related…
- Trial name
- NCT03005119
- Testing
- PTL201
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- PhytoTech Therapeutics, Ltd.
Multiple Sclerosis
Out of Pocket Cost Communication in Multiple Sclerosis Patients
This is a prospective randomized controlled trial of a cohort of adult multiple sclerosis (MS) patients visiting an outpatient neurology clinic.
- Trial name
- NCT04257071
- Testing
- Usual Care, OOP Cost Communication and Optimization
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Multiple Sclerosis
BENEFIT Study (Betaferon® / Betaseron® in Newly Emerging Multiple Sclerosis for Initial Treatment) and BENEFIT Follow-up Study
This study will primarily compare the long-term effects of an early and continued treatment with Betaferon/Betaseron (patients who were treated with active medication during the double-blind BENEFIT study) to treatment initiated…
- Trial name
- NCT00185211
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- 94 sites in Austria, Belgium and 18 more
- Volunteers
- 468 people
- Sponsor
- Bayer
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Multiple Sclerosis
Effectiveness of Task Specific Home Exercise Program
The purpose of this study is to compare the effectiveness of 2 different types of Home Exercise Programs (HEP) on mobility in persons with Multiple Sclerosis (MS).
- Trial name
- NCT06486116
- Testing
- Task Specific Physical Therapy Home Program
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Neuromyelitis Optica Spectrum Disorder, Transverse Myelitis
Central Pain Study for ABX-1431
This study will determine the safety and tolerability of ABX-1431 in patients with central pain when added on to background pain therapy.
- Conditions
- Neuromyelitis Optica Spectrum Disorder, Transverse Myelitis, Multiple Sclerosis, Longitudinally Extensive Transverse Myelitis
- Trial name
- NCT03138421
- Testing
- ABX-1431 HCl
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- Abide Therapeutics