Clinical trials: multiple sclerosis
Multiple Sclerosis
Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization…
- Trial name
- NCT00006060
- Testing
- standard gadolinium contrast
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Multiple Sclerosis
Effects of Dalfampridine on Cognition in Multiple Sclerosis
Cognitive impairment is common in multiple sclerosis (MS) and has devastating impact on functional activities. There is great demand for medications that will enhance cognitive capacity in MS patients.
- Trial name
- NCT02006160
- Testing
- dalfampridine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- State University of New York at Buffalo
Migraine, Headache
RELAXaHEAD for Headache Patients (Phase II)
The goal of this research is to assess the utility of smartphone-based progressive muscle relaxation (PMR) for the treatment of migraine and sleep.
- Conditions
- Migraine, Headache, Multiple Sclerosis, Insomnia
- Trial name
- NCT05466682
- Testing
- Smartphone-Based Progressive Muscle Relaxation Therapy (PMR), Monitored Usual Care (MUC)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Cognitive Evolution in Tysabri Treated Multiple Sclerosis Patients - A Three Year Extension
This study is designed to demonstrate that Tysabri is effective in maintaining cognition in MS patients after 5 or more years of continuous treatment.
- Trial name
- CogMS-Ext (NCT02383550)
- Testing
- Observational Cognitive assessments
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Clinique Neuro-Outaouais
Multiple Sclerosis
Comparative Study of the Efficacy and Safety of BCD-132 With Teriflunomide and Placebo in Multiple Sclerosis
International multicenter, randomized, double-blind, double-masked, placebo-controlled study of efficacy and safety of BCD-132 (JSC BIOСAD, Russia) using an active reference drug (teriflunomide) for the treatment of patients with…
- Trial name
- NCT04056897
- Testing
- BCD-132, 125 mg, Teriflunomide, BCD-132, 500 mg
- Where
- Russia
- Volunteers
- 271 people
- Sponsor
- Biocad
Relapsing-Remitting Multiple Sclerosis
Exploratory Study of the Safety, Tolerability and Efficacy of Multiple Regimens of Natalizumab in Adult Participants With Relapsing Multiple Sclerosis (MS)
The primary objective of this study is to explore the effects of multiple regimens of natalizumab on disease activity and safety in participants with relapsing-remitting Multiple Sclerosis (RRMS).
- Trial name
- REFINE (NCT01405820)
- Testing
- natalizumab IV, natalizumab SC
- Where
- 64 sites in Belgium, France and 3 more
- Volunteers
- 290 people
- Sponsor
- Biogen
Kinesiophobia, Multiple Sclerosis
Kinesiophobia Associated With Fatigue in Patients With Multiple Sclerosis.
This study aims to investigate the presence of kinesiophobia and the factors associated with kinesiophobia in patients diagnosed with multiple sclerosis.
- Trial name
- NCT07803523
- Where
- Turkey (Türkiye)
- Volunteers
- 352 people
- Sponsor
- Dokuz Eylul University
Spinal Cord Injuries, Gait Disorders, Neurologic
Validity and Reliability of the 12-item Multiple Sclerosis Walking Scale (12-WS) in Subjects With Spinal Cord Injury
Established gait assessments for subjects with spinal cord injury (SCI) (6MWT, 10MWT, TUG, SCIM III and WISCI II) are widely used in the clinical and research setting.
- Trial name
- 12-WS SCI (NCT06256159)
- Testing
- 12 MSWS questionnaire
- Where
- 2 sites in Switzerland
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Multiple Sclerosis
Characterizing Upper Extremity Function in Individuals With Multiple Sclerosis
Upper extremity (UE) function is critical to maintaining independence. Better understanding of UE involvement in MS will provide necessary information to prioritize the design and selection of future interventions.
- Trial name
- NCT02398149
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Mount Sinai Rehabilitation Hospital
Multiple Sclerosis
Validation of a Self-questionnaire in French on the Use of the Upper Limbs in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system that causes disability in young adults.
- Trial name
- MS-SEP (NCT03655093)
- Testing
- Validation of AMSQ questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Stem Cells in Rapidly Evolving Active Multiple Sclerosis
This is a randomised, double-blind crossover study to study the effect of intravenous treatment with autologous (derived from the individuals themselves) mesenchymal stem cells (MSCs) in patients with multiple sclerosis (MS).
- Trial name
- STREAMS (NCT01606215)
- Testing
- Mesenchymal stem cells
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Imperial College London
Multiple Sclerosis, Relapsing-Remitting
Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participants
The main objective of the study is to evaluate the efficacy of dimethyl fumarate (Tecfidera) and peginterferon beta-1a (Plegridy), both compared with placebo, in pediatric participants with RRMS.
- Trial name
- NCT03870763
- Testing
- Dimethyl Fumarate, Peginterferon Beta-1a
- Where
- 23 sites in United States, Colombia and 11 more
- Volunteers
- 11 people
- Sponsor
- Biogen
Multiple Sclerosis
Effectiveness of Task Specific Home Exercise Program
The purpose of this study is to compare the effectiveness of 2 different types of Home Exercise Programs (HEP) on mobility in persons with Multiple Sclerosis (MS).
- Trial name
- NCT06486116
- Testing
- Task Specific Physical Therapy Home Program
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Digital Ulcers, Systemic Sclerosis
Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma
In an earlier clinical trial, RAPIDS-1, conducted in scleroderma patients with or without digital ulcers at baseline, bosentan significantly reduced the number of new digital ulcers versus placebo.
- Trial name
- RAPIDS-2 (NCT00077584)
- Testing
- Bosentan 62.5 mg, Bosentan 125 mg
- Volunteers
- 188 people
- Sponsor
- Actelion
Multiple Sclerosis
Genes and Environment in Multiple Sclerosis
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS).
- Trial name
- GEMS (NCT01353547)
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis, Gait Disorders, Neurologic
TRAIN-BW: Backward Walking Training in Multiple Sclerosis
Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Accidental Fall
- Trial name
- TRAIN-BW (NCT04091464)
- Testing
- Backward Walking Training, Forward Walking Training
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Wayne State University
Multiple Sclerosis
REsPonse to Interferon-Alpha in InterfeRon-β Neutralizing Antibody Positive Multiple Sclerosis Patients
The purpose of the study is to determine if Interferon-alfa is effective and safe in multiple sclerosis patients who developed neutralizing antibodies for Interferon-beta.
- Trial name
- REPAIR (NCT01171209)
- Testing
- Interferon-beta and human leukocyte Interferon-α
- Volunteers
- 10 people
- Sponsor
- Melinda Magyari
Multiple Sclerosis, Stroke
Clinical and Instrumental Treatment's Predictors in Subjects With Neurological Diseases Using G-EO Robotic System
The aim of this work is to elaborate a statistical model to predict the effectiveness of robotic treatment in subjects with neurological diseases.
- Conditions
- Multiple Sclerosis, Stroke, Parkinson Disease, Acquired Brain Injury
- Trial name
- NCT05493514
- Testing
- Robotic Assisted Gait Training with G-EO system
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis
Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is…
- Trial name
- NCT06704464
- Testing
- Manual Dexterity, Manual Dexterity (only MMDT), disability level
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis, Relapsing-Remitting
Worms for Immune Regulation of Multiple Sclerosis
The purpose of this study is to determine whether people with MS who are exposed to a small number of hookworms will have less inflammation and less MS disease activity.
- Trial name
- WIRMS (NCT01470521)
- Testing
- Hookworm larvae
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Nottingham
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