Clinical trials: multiple sclerosis
Multiple Sclerosis
Use of Two Deep Brain Stimulation (DBS) Electrodes to Treat Post-Traumatic Tremor
The purpose of this research study is to: 1. Determine whether deep brain stimulation (DBS) with two leads (very thin coiled wires) placed unilaterally (on one side of the brain) is beneficial to patients with multiple sclerosis…
- Trial name
- NCT00954421
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Multiple Sclerosis
Immune Regulation in Multiple Sclerosis: The Effect of Glatiramer Acetate on MicroRNA Expression in Antigen-Presenting Cells
MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and glatiramer…
- Trial name
- NCT01993004
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Multiple Sclerosis
Non-invasive Spinal Cord Stimulation for Spasticity Control and Augmentation of Voluntary Motor Control in Individuals With Multiple Sclerosis
Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury.
- Trial name
- noSpasMS (NCT04486209)
- Testing
- transcutaneous spinal cord stimulation
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Vienna
Multiple Sclerosis, Spasticity, Muscle
Pilot Investigation to Evaluate FlowOx2.0™ for Experimental Treatment of Spasticity
This is a descriptive, prospective, non-controlled clinical investigation to be conducted on approximately 10 enrolled subjects at one site at Haukeland University Hospital in Bergen, Norway.
- Conditions
- Multiple Sclerosis, Spasticity, Muscle, Pain
- Trial name
- FlowOx-MS (NCT04904016)
- Testing
- FlowOx™
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Otivio AS
Stroke, Brain Injury
Motor Imagery Practice in Neurological Rehabilitation
Motor imagery is a technique widely used in learning skills. Its effectiveness has been proven in various sports and in musicians. A recent review (Braun et al.
- Conditions
- Stroke, Brain Injury, Multiple Sclerosis
- Trial name
- NCT00618085
- Testing
- Motor imagery practice, Standard physiotherapy and occupational therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Nuffield Orthopaedic Centre NHS Trust
Multiple Sclerosis
Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)
The objective of the trial is to study the safety and effectiveness of ABT-874 administered weekly or every other week in patients with relapsing remitting and secondary progressive multiple sclerosis as compared to placebo.
- Trial name
- NCT00086671
- Testing
- ABT-874/Human monoclonal antibody against IL-12
- Where
- 44 sites in United States, Canada and 3 more
- Volunteers
- 215 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Relapsing-Remitting Multiple Sclerosis
A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy.
- Trial name
- SOSTOS (NCT05090371)
- Testing
- Ofatumumab, Disease modifying treatment (DMT)
- Where
- 43 sites in United States, Canada
- Volunteers
- 136 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Relapsing-Remitting
Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis
This is a randomized, parallel group, placebo-controlled study designed to assess whether GSK239512 can enhance lesion remyelination in subjects with Relapsing Remitting Multiple Sclerosis (RRMS).
- Trial name
- NCT01772199
- Testing
- GSK239512
- Where
- 43 sites in Bulgaria, Canada and 6 more
- Volunteers
- 131 people
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells
Determine the in-vivo mechanism of action of INF-B-1b as it's mechanisms of action are not completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces tolerizing effect on DC-dependent T-cell…
- Trial name
- NCT00630721
- Testing
- IFNbeta-1b
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Multiple Sclerosis
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Copolymer 1 for Relapsing-Remitting Multiple Sclerosis
OBJECTIVES: I. Compare tolerance to and therapeutic impact of copolymer 1, a mixture of synthetic polypeptides, with placebo in patients with relapsing-remitting multiple sclerosis.
- Trial name
- NCT00004814
- Testing
- copolymer 1
- Volunteers
- 250 people
- Sponsor
- National Center for Research Resources (NCRR)
Multiple Sclerosis (MS)
Clinical Efficacy of Autologous Mesenchymal Bone Marrow Stem Cells in Active & Progressive Multiple Sclerosis
The purpose of this study is to evaluate the clinical efficacy and the optimal way of administration of autologous mesenchymal bone marrow stem cells (MSC) compering intravenous injection and intrathecal injection vs.
- Trial name
- NCT02166021
- Testing
- Mesenchymal stem cells
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Dimitrios Karussis
Multiple Sclerosis
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
Sleep disturbance, especially insomnia (i.e., difficulty initiating and maintaining sleep), affects over half of people with MS.
- Trial name
- NCT04147052
- Testing
- iSLEEPms
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Relapsing-remitting Multiple Sclerosis
Efficacy and Safety of Vatelizumab in Patients Who Completed Treatment in Study DRI13839
Primary Objective: To assess the long-term safety of vatelizumab in MS patients Secondary Objective: To assess the long-term efficacy of vatelizumab
- Trial name
- NCT02306811
- Testing
- Vatelizumab
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 62 people
- Sponsor
- Genzyme, a Sanofi Company
Multiple Sclerosis, Multiple Sclerosis (MS)
My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis
We are conducting this study to test if the new Toolkit depression module is accessible and helpful for people with multiple sclerosis (MS) in decreasing depression severity.
- Trial name
- NCT07636434
- Testing
- My MS Toolkit
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Washington
Optic Neuritis, Multiple Sclerosis
Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)
3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal…
- Trial name
- COCON (NCT04793087)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis, Tremor
The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
The incidence of tremor in Multiple Sclerosis (MS) has been estimated to affect up to 2/3rds of patients. Over half of the tremors involve the upper limb and frequently lead to further disability.
- Trial name
- NCT01018485
- Testing
- Botulinum Toxin Type A
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Multiple Sclerosis
Mindfulness-based Stress Reduction in Multiple Sclerosis
This application concerns a proposed randomised controlled trial evaluating the use of Mindfulness-based stress reduction (MBSR) in people with Multiple Sclerosis (MS) in secondary care.
- Trial name
- NCT02136485
- Testing
- Mindfulness-based stress reduction (MBSR), waiting list control
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- NHS Greater Glasgow and Clyde
Multiple Sclerosis, Gait Disorders, Neurologic
Effects of Core Stability Training on Gait in Multiple Sclerosis Patients
Gait and mobility are among the functions frequently affected in Multiple Sclerosis (MS) and have a negative impact on quality of life.
- Trial name
- NCT03442049
- Testing
- Physiotherapy - Study group, Physiotherapy - control group
- Volunteers
- 68 people
- Sponsor
- Hacettepe University
Multiple Sclerosis, Neuromyelitis Optica
Immunologic Biomarker Profile of Cerebrospinal Fluid
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
- Trial name
- BIOMOG (NCT04202055)
- Testing
- Biomarker analysis
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis
Transcranial Doppler in Multiple Sclerosis
The aim of this study is to investigate the potential of Transcranial doppler (TCD) and Near-Infrared Spectroscopy (NIRS), more simple and non-invasive bedside methods than magnetic resonance imaging (MRI), to evaluate changes in…
- Trial name
- TRADOMS (NCT02389426)
- Testing
- TCD baseline, TCD after bosentan administration, NIRS baseline
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
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