Clinical trials: multiple sclerosis
Multiple Sclerosis
Cognitive-motor Interference in Persons With MS
Dual tasking such as walking while talking on the phone or while remembering a shopping list is very frequently required in everyday life.
- Trial name
- NCT04158063
- Testing
- Dual Task Training, Single Mobility Training
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis, Lower Urinary Tract Symptoms
Multiple Sclerosis and Voiding Symptoms: How to Assess?
In multiple Sclerosis (MS), storage and voiding symptoms are well described. Urodynamic patterns underlying storage symptoms are clearly defined, but the assessment of voiding phase in neurological diseases is a sensitive topic.
- Conditions
- Multiple Sclerosis, Lower Urinary Tract Symptoms, Voiding Disorders
- Trial name
- NCT04928716
- Testing
- voiding phase evaluation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Pierre and Marie Curie University
Multiple Sclerosis
Allogeneic Mesenchymal Stem Cell-Derived Exosome Therapy for Progressive Multiple Sclerosis
The goal of this clinical trial is to learn if intravenous infusion of allogeneic mesenchymal stem cell (MSC)-derived exosomes can slow disability progression and improve neurological function in adults with progressive multiple…
- Trial name
- NCT07146087
- Testing
- MSC-Derived Exosomes
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Biocells Medical
Secondary Progressive Multiple Sclerosis (SPMS)
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
The purpose of this study is to provide efficacy and safety data for remibrutinib in patients with secondary progressive multiple sclerosis (SPMS)
- Trial name
- REMASTER (NCT07225504)
- Testing
- Remibrutinib (blinded), Remibrutinib (Open label)
- Where
- 296 sites in United States, Argentina and 34 more
- Volunteers
- 1,275 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
RIPC on Activity, Fatigue and Gait in MS
This study evaluates whether Remote Ischaemic Preconditioning (RIPC) can improve activity, gait and fatigue in people with Multiple Sclerosis. Half the participants will receive RIPC, the other half will receive a sham treatment.
- Trial name
- MSIPC-2 (NCT03967106)
- Testing
- Ischaemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 92 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Multiple Sclerosis
Measuring Blood Vessel Density in the Optic Nerve of Multiple Sclerosis Patients With OCTA
The goal of this observational study is to learn about the effect of multiple sclerosis on the blood flow of the optic nerve of affected patients compared to normal subjects by OCTA. The main question it aims to answer is: 1.
- Trial name
- NCT07629804
- Testing
- Optical Coherence Tomography Angiography
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Fayoum University
TSC
TSC Remote Assessment and Intervention
The investigators propose a study to adapt an evidence-based caregiver training program to improve access in order to better serve the TSC community.
- Trial name
- TRAIN (NCT04698538)
- Testing
- JASPER
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis, Transcranial Direct Current Stimulation
The Effects of Two Types of t-DCS Stimulation on Robot-assisted Gait Training in Patients With Multiple Sclerosis
The primary aim of this study is to determine the transcranial direct current stimulation and transcutaneous spinal direct current stimulation in addition to robot-assisted walking training in individuals with Multiple sclerosis…
- Trial name
- NCT06121635
- Testing
- Transcutaneous Spinal Direct Current Stimulation and Transcranial Direct Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul Medeniyet University
Multiple Sclerosis, Relapsing-Remitting
Multiparametric Assessment to Investigate Prognostic Factors for Disease Evolution a nd Evolutionary Patterns of Cognitive Status in RRMS
This prospective study combining non conventional MRI techniques, neuropsychological screening tools, and a neurophysiological work-up using a sensitive and validated battery, will evaluate the predictive value of these measures…
- Trial name
- COGNIT-MS (NCT05510817)
- Testing
- Multiparametric assessment
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Multiple Sclerosis
The Effects of Attention Retraining in MS
The purpose of this study is to determine whether neuropsychological rehabilitation focused on attention retraining and teaching compensatory strategies has positive effects on cognitive performance, quality of life (QoL)and…
- Trial name
- MSattention (NCT01492023)
- Testing
- neuropsychological rehabilitation
- Where
- 3 sites in Finland
- Volunteers
- 97 people
- Sponsor
- Finnish MS Society
Multiple Sclerosis
A Study of End of Dose Phenomena in Subcutaneous Natalizumab Treated Multiple Sclerosis (MS) Participants
The primary objective of this study is to better understand the pathophysiological background of end-of-dose symptoms (EOD) and thereby determine the percentage of participants who develop EOD under natalizumab (NTZ) as an…
- Trial name
- SATURATE-MS (NCT05701423)
- Testing
- Natalizumab
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Biogen
Relapsing-Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS
The study is an investigator-run, open-label Phase 1 safety study of autologous mesenchymal stem cell transplantation, involving approximately 24 ambulatory participants with relapsing forms of MS (approximately equal numbers…
- Conditions
- Relapsing-Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
- Trial name
- NCT00813969
- Testing
- Autologous mesenchymal stem cell transplantation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Cleveland Clinic
Multiple Sclerosis, Relapsing-Remitting
Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two
The purpose of this study was to establish the efficacy and safety of two different doses of alemtuzumab (Lemtrada™) as a treatment for relapsing-remitting multiple sclerosis (MS), in comparison with subcutaneous interferon…
- Trial name
- CARE-MS II (NCT00548405)
- Testing
- Alemtuzumab 12 mg, Alemtuzumab 24 mg, Interferon beta-1a
- Where
- 191 sites in United States, Argentina and 21 more
- Volunteers
- 840 people
- Sponsor
- Genzyme, a Sanofi Company
Multiple Sclerosis
Using Motor Imagery-based Brain-computer Interface With Multiple Sclerosis Patients.
The goal of this clinical trial is to evaluate the effectiveness of a wearable brain-computer interface (BCI)-based neurofeedback system using motor imagery (MI) to support upper limb motor rehabilitation in patients with…
- Trial name
- BCI_MI_SM_2026 (NCT07472556)
- Testing
- Brain Computer Interface
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Pasquale Arpaia
Relapse Remitting Multiple Sclerosis
Immunoregulatory Effect of Microparticle Delivered STING Agonist in the Control of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)
Microparticles (MPs) as a mode of therapeutic delivery can selectively deliver immunomodulatory treatment to the phagocytic cells, particularly dendritic cells (DCs), inducing their tolerogenic phenotype and function and T…
- Trial name
- NCT05705986
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Simvastatin Multiple Sclerosis
Role of Simvastatin in Relapsing-Remitting Multiple Sclerosis
The purpose of the clinical trial is to test how Simvastatin (80mg/day) may decrease attacks and progression of disease in patients with multiple sclerosis under disease modifying therapy (DMTs)
- Trial name
- NCT04178980
- Testing
- Simvastatin in relapsing remitting multiple sclerosis
- Volunteers
- 60 people
- Sponsor
- Assiut University
Primary Progressive Multiple Sclerosis, Exercise
The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
Endurance training revealed to be an effective means to increase cardiorespiratory fitness in persons with Multiple Sclerosis (MS), considered relevant to health-related quality of life in this population.
- Conditions
- Primary Progressive Multiple Sclerosis, Exercise, Cardiorespiratory Fitness
- Trial name
- CYPRO (NCT05229861)
- Testing
- HIIT, MCT
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- Klinik Valens
Multiple Sclerosis, Fatigue
The Effect of Music and Progressive Relaxation Exercise on Fatigue and Sleep in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic complex neurodegenerative disease that targets the central nervous system and is autoimmune. The prevalence of fatigue in individuals diagnosed with MS varies between 50% and 81%.
- Conditions
- Multiple Sclerosis, Fatigue, Sleep
- Trial name
- NCT06468241
- Testing
- Progressive relaxation exercise, Listening to music
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis
Tecfidera and MRI for Brain Energy in MS
The primary objective of this study is to test the hypothesis that DMF can improve mitochondrial function in the brain of people with MS.
- Trial name
- NCT02644083
- Testing
- Dimethyl fumarate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Finding Patterns In Clinical Study Experiences of Multiple Sclerosis Patients
Participation in medical trials usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups.
- Trial name
- NCT05503524
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
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