Clinical trials: on Invasive Mechanical Ventilation
Heart; Dysfunction Postoperative, Cardiac Surgery
Non-invasive Mechanical Ventilation After Cardiac Surgery
Non-invasive mechanical ventilation (NIV) has been used in hypoxic post-operative cardiac patients but more studies are necessary to clarify its respiratory and hemodynamic effects.
- Trial name
- NCT01457898
- Testing
- VPAP II®
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
Mechanical Ventilation, Weaning
Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients
the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.
- Trial name
- NCT05629819
- Testing
- Non-invasive phrenic nerve stimulation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Bing Sun
Respiratory Physiotherapy
Effects on the Expiratory Flow of AAD in a Critical Patient With IMV
One of the detrimental effects of invasive mechanical ventilation (IMV) is the alteration of the patient's mucociliary system that requires ventilatory support.
- Trial name
- NCT06551636
- Testing
- respiratory physiotherapy (AAD)
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Parc Taulí Hospital Universitari
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Myotonic Dystrophy 1, Steinert Disease
Ventilatory Response After Non Invasive Ventilation in Type 1 Myotonic Dystrophy
It has been suggested that patients with Myotonic Dystrophy type 1 have primary altered ventilatory response to chemical stimuli and chronic hypoventilation is related not always to muscle weakness.
- Trial name
- NCT02880735
- Testing
- Non Invasive Ventilation.
- Where
- Mexico
- Volunteers
- 27 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Resting Energy Expenditure, Indirect Calorimetry
Comparison of the Effects of SIMV-PC and SIMV-VC Ventilation Modes on Resting Energy Expenditure
The primary objective of this prospective observational study is to compare the effects of synchronized intermittent mandatory ventilation in pressure-controlled mode (SIMV-PC) and volume-controlled mode (SIMV-VC) on resting…
- Trial name
- NCT07790341
- Testing
- Volume-controlled ventilation, Pressure-controlled ventilation
- Volunteers
- 41 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Heart Diseases, Coronary Artery Disease
Influence of Non Invasive Mechanical Ventilation on Tissue Perfusion in Patients After Cardiac Surgery
This study evaluates whether noninvasive ventilation with continuous positive airway pressure affects tissue perfusion in patients after cardiac surgery.
- Trial name
- NCT02767687
- Testing
- Noninvasive ventilation
- Volunteers
- 80 people
- Sponsor
- Federal University of São Paulo
Lung Diffusion, Acute Respiratory Failure
Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide During General Anaesthesia
Mechanical ventilation is a therapeutic method used in order to keep gas exchange adequate to cell metabolism in patients with acute respiratory failure.
- Trial name
- NCT01503879
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- San Gerardo Hospital
Respiratory Insufficiency, Respiration, Artificial
Effects Of Invasive And Noninvasive Mechanical Ventilation On Sleep In The Intensive Care Unit (ICU)
The purpose of this study is to monitor sleep in patients using breathing machines, because little is known about sleep when patients use masks to help their breathing.
- Conditions
- Respiratory Insufficiency, Respiration, Artificial, Sleep Deprivation
- Trial name
- NCT00638339
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Tufts Medical Center
Invasive Mechanical Ventilation, Extubation Time
Measurement of Efferent Neural Drive From Respiratory Centers to Upper Airways Using Electromyography (EMG) of Genioglossus (GG) in Patients Dependent on Invasive Mechanical Ventilation
Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration.
- Trial name
- NCT07842484
- Testing
- electromyography (EMG) of genioglossus (GG)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Non-invasive Mechanical Ventilation
Audio Books Effects on Anxiety and Vital Sings
Objectives: This study aimed to investigate the effect of audio book use on anxiety and vital signs in patients receiving non-invasive mechanical ventilation (NIMV) support.
- Trial name
- NCT06378970
- Testing
- Audio Book Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ege University
Neuromuscular Diseases, Non Invasive Ventilation
Impact of the Pre-phonatory Inspiratory Volume on the Speech Quality of Neuromuscular Patients Dependent on Non-invasive Ventilation
We want to demonstrate that modifications of the ventilation parameters are liable to improve the different characteristics of phonation (duration, intensity, prosody..) in neuromuscular patients who are dependent on non invasive…
- Trial name
- PREPHONO (NCT03381937)
- Testing
- speech trial
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
on Invasive Mechanical Ventilation, ARDS
Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury.
- Conditions
- on Invasive Mechanical Ventilation, ARDS, Respiratory Failure
- Trial name
- NCT04035915
- Testing
- Limited driving pressure, Conventional mechanical ventilation strategies
- Where
- Thailand
- Volunteers
- 126 people
- Sponsor
- Mahidol University
Acute Respiratory Distress Syndrome, Pressure Ulcers Stage III
Comparaison of Two Prone Position Techniques on Occurence of Pressure Sores in ICU
Acute respiratory distress syndrome (ARDS) is a diffuse inflammation of the lungs that occurs in a variety of diseases. According to the Berlin definition, ARDS is characterized by diffuse lung damage in patients with…
- Trial name
- PROPOSE (NCT05894291)
- Testing
- Swimmer Prone Position, Prone position with arms alongside the body
- Where
- France
- Volunteers
- 334 people
- Sponsor
- University Hospital, Tours
Copd, COPD Exacerbation
Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation
Acute exacerbation of COPD (AECOPD) worsen prognosis and quality of life of COPD patients. Telemonitoring could be a useful tool for early identification of AECOPD. Parameters that have to be monitored are not well defined.
- Trial name
- NCT03018470
- Testing
- Analysis of data from NIV built-in software
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Aspiration Pneumonia
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms.
- Trial name
- APAPI (NCT03763799)
- Testing
- PCR-based microbiological diagnosis strategy, Standard microbiological diagnosis strategy
- Where
- 2 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Lille
Ventilator-Associated Pneumonia Prevention and Intensive Care Nursing Care
Theory-Based Educational Program for VAP Prevention and Nursing Care in Intensive Care Units
Ventilator-associated pneumonia (VAP) is an important challenge in intensive care and requires nurses to apply evidence-based preventive practices consistently in mechanically ventilated patients.
- Trial name
- TSEP-VAP-2026 (NCT07820826)
- Testing
- Theory-Based Structured Educational Program, Usual Care
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- JAWAD AHMAD ABU-SHENNAR
COPD, Mechanical Ventilation
Effect of Invasive and Non Invasive Mechanical Ventilation on Feeding Delivery in COPD Elderly Patients
COPD patients requiring ventilation may benefit from invasive or non invasive ventilation. Non invasive ventilation is often incompatible with oral or enteral feding, due to gastric dilatation and full mask therapy.
- Trial name
- NCT00417755
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center