Clinical trials: on Invasive Mechanical Ventilation
Pneumonia, Atelectasis
Effects of Invasive Mechanical Ventilation on the Right Ventricular Function
The goal of this observational study is to learn about the influence of mechanical ventilation on the right ventricular (RV) function.
- Conditions
- Pneumonia, Atelectasis, ARDS
- Trial name
- NCT05710419
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Giessen
Atelectasis, Ventilation, Mechanical
Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients
The investigators hypothesized that dornase alpha, administered twice a day (BID) by in-line nebulizer, would improve oxygenation, compliance, and time to extubation in adult patients receiving mechanical ventilation.
- Trial name
- NCT01095276
- Testing
- Pulmozyme (nebulized dornase alpha), Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Respiratory Distress Syndrome, Adult, Acute Lung Injury
Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome
PFCs (perfluorocarbons, PFC), an ideal liquid respiratory media, has special chemical and biological properties, including high solubility of gas, swiftness of carrying and release, low surface tension, high proportion, almost…
- Trial name
- NCT01391481
- Testing
- Perfluorocarbon, Sterile Water for Injection
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Mucus Retention, Mechanical Ventilation Complication
Efficacity and Safety of Mechanical Insufflation-exsufflation on ICU
Critically ill and intubated patients on mechanical ventilation (IMV) often present retention of respiratory secretions, increasing the risk of respiratory infections and associated morbidity.
- Conditions
- Mucus Retention, Mechanical Ventilation Complication, Mucus; Plug, Tracheobronchial
- Trial name
- NCT03316079
- Testing
- Chest physiotherapy techniques, Mechanical insufflation-exsufflation
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Mechanical Ventilation, Neuromuscular Electrical Stimulation (NMES)
The Impact Of Respiratory Neuromuscular Stimulation On Patients With Invasive Mechanical Ventilation
Mechanical ventilation (MV) is an important treatment measure for critically ill patients in the intensive care unit (ICU). MV is widely used in the treatment of respiratory failure and is also one of the important means of life…
- Trial name
- NCT06952335
- Testing
- Phrenic nerve stimulation at 8mA, Phrenic nerve stimulation at 15mA, Phrenic nerve stimulation at 15mA combined with phrenic-abdominal stimulation at 15mA
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Capital Medical University
Chronic Heart Failure
Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study
The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures.
- Trial name
- HiFlow-Heart (NCT04471129)
- Testing
- HFO/O2C/NIV, NIV/O2C/HFO
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
ICU Acquired Weakness
Impact of Early Mobilization on Mechanical Ventilation Duration in Intubated Critically Ill Patients
The purpose of the present study is to compare usual care in terms of mobilization performed to intubated ICU patients to a standardized program designed to deliver early mobilization at least 5 days a week.
- Trial name
- EarlyMob (NCT02520193)
- Testing
- Protocolized early mobilization in ICU
- Where
- 23 sites in Belgium, France and 1 more
- Volunteers
- 772 people
- Sponsor
- University Hospital, Angers
COVID-19, Undefined
A Clinical Safety Study on AT-100 in Treating Adults With Severe COVID-19 Infection or Severed Community Acquired Pneumonia
The purpose of this study is to determine if an investigational drug, AT-100, is safe and tolerated by adults who have severe corona virus disease 2019 (COVID-19) or respiratory failure secondary to severe community acquired…
- Trial name
- NCT04659122
- Testing
- AT-100
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Airway Therapeutics, Inc.
Diaphragm Dysfunction, COPD Exacerbation
Influence of Respiratory Mechanics on Diaphragmatic Dysfunction in COPD Patients Who Have Failed NIV (RHYDIAN)
Although non-invasive mechanical ventilation (NIV) is the gold standard treatment for patients with acute exacerbation of COPD (AECOPD) who develop respiratory acidosis, failure rate are still high ranging from 5% to 40%.
- Conditions
- Diaphragm Dysfunction, COPD Exacerbation, Mechanical Ventilation
- Trial name
- RHYDIAN (NCT03852394)
- Testing
- Respiratory mechanics assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Modena and Reggio Emilia
Neuromuscular Disorder, Respiratory Failure
Evaluation of the Impact on Swallowing of Non Invasive Ventilation
Neuromuscular disorders can be associated with swallowing dysfunction secondary to a dysfunction of the airway muscles involved in swallowing.
- Conditions
- Neuromuscular Disorder, Respiratory Failure, Swallowing, Mechanical Ventilation
- Trial name
- OPTIDEG (NCT01519388)
- Testing
- Spontaneous breathing, Elysée 150®
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Pupillometry, Behavioral Pain Scale
Pupillometry vs. BPS (Behavioral Pain Scale) for Analgesia Management in Inpatient Intensive Care Unit Patients on Invasive Mechanical Ventilation
Patients admitted to the intensive care unit (ICU) and receiving invasive mechanical ventilation (IMV) frequently require sedation and analgesia to ensure their comfort, prevent pain associated with invasive procedures, and…
- Conditions
- Pupillometry, Behavioral Pain Scale, Analgesia Assessment, Intensive Care Unit (ICU)
- Trial name
- GOLDEN EYE (NCT07867678)
- Testing
- PPI Measurement (Pupillary Pain Index), BPS Measurement (Behavioral Pain Scale)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Neuromuscular Diseases, Mechanical Ventilation
Evaluation of the Effect of a Speech Detection Tool on the Improvement of Phonation in Neuromuscular Patients Dependent on Mechanical Ventilation
Ventilation is a major treatment of respiratory failure due to neuromuscular disorders. First line treatment is noninvasive ventilation (NIV) but in some situations, especially in case of NIV inefficiency, invasive ventilation…
- Conditions
- Neuromuscular Diseases, Mechanical Ventilation, Speech
- Trial name
- Ventiphono (NCT03504514)
- Testing
- speech trials during different ventilation conditions, speech trial
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Critical Illness
Early Mobilization for Critical Patients on Invasive Mechanical Ventilation in the Intensive Care Unit
A single blind randomized controlled trial (the MoVe ICU study) will be conducted to evaluate the effects on critical patients on invasive mechanical ventilation of early mobilization with a cycle ergometer.
- Trial name
- MoVe-ICU (NCT02300662)
- Testing
- Cycle Ergometer, Conventional physiotherapy
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiometry, Thorathic Fluid Content
The Validity of Thorathic Fluid Content as Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients
Introduction Weaning from mechanical ventilation (MV) could be described as the process of removing ventilator support. Weaning from MV often implies two separate but closely linked views of care, elimination of MV of any…
- Conditions
- Cardiometry, Thorathic Fluid Content, Weaning From Mechanical Ventilation
- Trial name
- NCT06685406
- Testing
- Thorathic fluid content measurement by cardiometry
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Airway Extubation
Analysis of the Magnetic Tape Bandage on Respiratory Functional Effects.
Invasive mechanical ventilation (IMV) is the mainstay of supportive care in acute respiratory failure. However, maintaining ventilatory support beyond what is necessary may increase the risk of nosocomial infections, favour…
- Trial name
- NCT05356299
- Testing
- Magnetictape bandage application
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital Universitario Doctor Peset
Nasal Injury
The Effect of Hydrocolloid Tape and Facial Massage in Premature Infants During Noninvasive Mechanical Ventilation
The aim of this study is to assess the effect of nasal injury prevention interventions (NIPI) (hydrocolloid tape and facial massage) on nasal septum injury, stress and comfort of premature neonates (28-35 weeks gestation)…
- Trial name
- NIPI (NCT05844345)
- Testing
- Hydrocolloid barrier group, Facial Massage group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ordu University
Non Invasive Ventilation (NIV)
Stress Ball Use in Non-Invasive Mechanical Ventilation Patients
Non-invasive mechanical ventilation is the first-line treatment for acute respiratory failure in patients with type II respiratory failure.
- Trial name
- NCT07752004
- Testing
- With stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Weaning From Mechanical Ventilation, Tracheostomy Weaning
Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation
Rationale: Tracheostomized patients weaning from mechanical ventilation are at risk for dryness of airway mucosa and sputum accumulation during disconnection from mechanical ventilation.
- Conditions
- Weaning From Mechanical Ventilation, Tracheostomy Weaning, Respiratory Failure
- Trial name
- PIONEER (NCT06776939)
- Testing
- Oxygen therapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Henrik Endeman
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health