Clinical trials: psoriasis
Psoriasis
Dose Ranging Study to Compare the Efficacy and Safety of Methotrexate in Plaque Type Psoriasis
In this study the investigators intend to compare the efficacy and safety of two fixed doses of once weekly oral methotrexate in a prospective randomized double blind manner in patients with severe plaque type psoriasis.
- Trial name
- NCT01187264
- Testing
- Methotrexate
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Psoriasis, Vascular Inflammation
Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis
This study is a double-blinded randomized multicenter placebo controlled trial to determine the effect of adalimumab on vascular inflammation (ascending aorta and carotides) in patients with moderate to severe psoriasis.
- Conditions
- Psoriasis, Vascular Inflammation, Coronary Atherosclerosis
- Trial name
- NCT01722214
- Testing
- Adalimumab
- Where
- 5 sites in Canada
- Volunteers
- 107 people
- Sponsor
- Innovaderm Research Inc.
Psoriasis
Deucravacitinib Adherence Study
Psoriasis patients are very poorly adherent to topical treatment. If adherence issues are ignored, poor adherence may limit the real-world efficacy of deucravacitinib, too.
- Trial name
- NCT05570955
- Testing
- Text reminder
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Rheumatoid Arthritis, Inflammatory Bowel Disease
Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis
Purpose: With the existing biologic anti-inflammatory product patents expiring and the FDA approval of new biosimilar and innovator biologics, patients with rheumatologic (RA), psoriatic (PsO-PsA-AS), and gastrointestinal (GI)…
- Conditions
- Rheumatoid Arthritis, Inflammatory Bowel Disease, Psoriasis, Psoriatic Arthritis
- Trial name
- NCT02922192
- Testing
- TNF-α antagonists, non-TNFs, DMARD non-biologics
- Volunteers
- 90,360 people
- Sponsor
- Biologics & Biosimilars Collective Intelligence Consortium
Psoriasis
Effectiveness of a Digital Health Application for Psoriasis
This clinical trial with 348 patients with psoriasis aims to investigate the effectiveness of a self-guided online program for patients with psoriasis.
- Trial name
- NCT06027034
- Testing
- Online program for psoriasis (GAIA-PSO-01)
- Where
- Germany
- Volunteers
- 348 people
- Sponsor
- Gaia AG
Psoriasis
Skin Tape Harvesting for Transcriptomics Analysis
Transcriptomics is the study of how RNA is expressed under specific conditions. Transcriptomic analyses of lesional skin biopsies can be a useful way to track how a patient responds to a drug and separate out drug responders from…
- Trial name
- NCT03048721
- Testing
- Skin Tape Stripping, Punch Biopsy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Psoriasis
Efficacy and Safety of Infliximab Biosimilar Remsima in Psoriasis
Psoriasis is a persistent condition which demands prolonged management, so it puts heavy financial as well as psychological burden on patients. Severe psoriasis makes work impossible for patients.
- Trial name
- NCT06043752
- Testing
- Remsima
- Where
- Pakistan
- Volunteers
- 51 people
- Sponsor
- Ghurki Trust and Teaching Hospital
Psoriasis
Safety and Efficacy of Etanercept in Patients With Psoriasis Who Failed to Respond to Other Biologic Treatments
The purpose of this study is to evaluate safety and efficacy of etanercept in patients with psoriasis who had an unsatisfactory response to adalimumab and infliximab.
- Trial name
- NCT00967538
- Testing
- etanercept 50 mg
- Where
- 16 sites in Canada
- Volunteers
- 89 people
- Sponsor
- Innovaderm Research Inc.
Psoriasis Vulgaris
A Psoriasis Plaque Test Study With LEO 90100 Cutaneous Spray, Ointment, in Psoriasis Vulgaris
The purpose of the study is to evaluate the anti-psoriatic effect of LEO 90100 cutaneous spray ointment, using the psoriasis plaque test modified from the method developed by KJ Dumas and JR Scholtz.
- Trial name
- NCT01347255
- Testing
- LEO90100 cutaneous spray, ointment, LEO 90100 cutaneous spray, ointment, vehicle with betamethasone dipropionate, LEO 90100 cutaneous spray, ointment, vehicle
- Where
- France
- Volunteers
- 24 people
- Sponsor
- LEO Pharma
Pediatric Psoriasis
Clinical, Epidemiologic, and Therapeutic Characterization of Pediatric Psoriasis in the Costa Rican Social Security System
The goal of this retrospective observational study is to characterize the clinical features, severity, comorbidities, and treatment patterns of pediatric psoriasis in patients managed in the Costa Rican Social Security System.
- Trial name
- NCT07451626
- Where
- Costa Rica
- Volunteers
- 300 people
- Sponsor
- Caja Costarricense de Seguro Social
Moderate to Severe Psoriasis
Study Evaluating the Efficacy and Safety of Etanercept and Acitretin in Korean Patient With Moderate to Severe Psoriasis
To compare the efficacy of ETN 50mg twice weekly for 12 weeks followed by reduction to a maintenance dose of 25mg twice weekly at week 24 with that of combination of ETN 25 mg Twice Weekly plus Acitretin 10mg BID at week 24 in…
- Trial name
- NCT00936065
- Testing
- Etanercept, Etanercept + Acitretin, Acitretin
- Where
- 10 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Pfizer
Autoimmune Diseases, Inflammatory Bowel Diseases
Chronic Inflammatory Disease, Lifestyle and Treatment Response
Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin…
- Conditions
- Autoimmune Diseases, Inflammatory Bowel Diseases, Crohn Disease (CD), Colitis, Ulcerative (UC)
- Trial name
- BELIEVE (NCT03173144)
- Testing
- Primary exposure variable, Other (exploratory) exposure variables
- Where
- 3 sites in Denmark
- Volunteers
- 233 people
- Sponsor
- University of Southern Denmark
Pediatric Plaque Psoriasis
Pediatric Open-Label Extension Study of Etanercept in Patients With Plaque Psoriasis
The purpose of this study is to evaluate the long-term safety and efficacy of etanercept in pediatric patients with moderate to severe psoriasis.
- Trial name
- NCT00141921
- Testing
- Etanercept
- Volunteers
- 182 people
- Sponsor
- Amgen
Arthritis, Rheumatoid, Arthritis, Psoriatic
PANLAR's Latin American Registry of Rheumatic Patients Treated With Jak Inhibitors
This prospective, non-interventional, research registry is designed to study the comparative safety and comparative effectiveness of approved Jak Inhibitors treatment for RA-PsA-SpA in a cohort of patients and theirs controls…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondyloarthritis
- Trial name
- PREJAK (NCT04821206)
- Testing
- DMARDs, biologic DMARDs, JAK Inhibitor
- Where
- 2 sites in Argentina
- Volunteers
- 3,000 people
- Sponsor
- Liga Panamericana de Asociaciones de Reumatologia (PANLAR)
Psoriasis
Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients
The primary objective of this trial is to investigate the safety and efficacy of BI 655130 in patients with PPP following multiple intravenous administrations compared to placebo.
- Trial name
- NCT03135548
- Testing
- Spesolimab (low dose), Spesolimab (high dose)
- Where
- 18 sites in Canada, Denmark and 4 more
- Volunteers
- 59 people
- Sponsor
- Boehringer Ingelheim
Psoriasis, Atherosclerosis
The Early Detection and Progression of Subclinical Atherosclerosis in Psoriasis
The goal of this observational study is to identify new molecular and imaging markers associated with the presence of atherosclerosis and its progression in psoriasis.
- Trial name
- EDSAP (NCT05858099)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Psoriasis
Cream Containing Sericin and Turmeric in Psoriasis Patients
Psoriasis lesion is divided into two parts. Half of the lesion will apply cream containing sericin and turmeric and another will apply steroid cream (control). The samples will be apply two times a day for 8 weeks.
- Trial name
- NCT06482398
- Testing
- Sericin extract and turmeric extract cream, Triamcinolone acetonide 1% Cream
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Plaque Psoriasis
Observational Real-world Evidence (RWE) Study to Assess Patient-reported Wellbeing Using Tildrakizumab in Live Setting - POSITIVE Study
This is an ethics-approved, multi-national, multi-site Phase IV, 1-cohort prospective observational study. The main purpose of this study is to assess the effect of tildrakizumab on the overall wellbeing in patients with…
- Trial name
- POSITIVE (NCT04823247)
- Testing
- Tildrakizumab
- Where
- Germany
- Volunteers
- 782 people
- Sponsor
- Almirall, S.A.
Psoriasis
Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis
Suppression Potential of Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects with Moderate to Severe Plaque Psoriasis.
- Trial name
- NCT03058744
- Testing
- IDP-118 Lotion, HP Monad Lotion, Ultravate Cream
- Where
- 12 sites in United States
- Volunteers
- 94 people
- Sponsor
- Bausch Health Americas, Inc.
Psoriasis
Improving Psoriasis Through Health and Well-Being
The purpose of the study is to examine and compare the effects of the Mindfulness-Based Stress Reduction (MBSR) program and the Living Well (LW) program on adults with psoriasis in terms of how these programs may affect their…
- Trial name
- NCT01162252
- Testing
- Mindfulness-Based Stress Reduction, Living Well
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Rochester
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