Clinical trials: psoriasis
Psoriasis, Cardiovascular Diseases
The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis
Psoriasis vulgaris is no longer considered as a chronic inflammatory disease restricted to the skin. Evidence has accumulated in the past that psoriasis is a chronic inflammatory systemic disease.
- Conditions
- Psoriasis, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- CASTIP (NCT01088165)
- Testing
- Adalimumab treatment arm, Fumaric acid esters treatment group, Narrow band UVB radiation
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- Medical University of Vienna
Psoriasis Vulgaris
LEO 90100 Aerosol Foam Compared to Calcipotriol Plus Betamethasone Dipropionate Gel in Subjects With Psoriasis Vulgaris
The purpose is to compare the efficacy of treatment with LEO 90100 at Week 4 to that of calcipotriol plus betamethasone dipropionate (BDP) gel at Week 8 in subjects with psoriasis vulgaris
- Trial name
- NCT02132936
- Testing
- LEO 90100 aerosol foam, Aerosol foam vehicle, Calcipotriol BDP gel
- Where
- France
- Volunteers
- 504 people
- Sponsor
- LEO Pharma
Diet Habit, Rheumatologic Disease
Rheumatology Diet Study
This study aims to collect information on rheumatology patients' dietary habits, autoimmune disease activity, dietary changes, disease symptom improvements, and perceptions on their dietary habits and how it affects their…
- Conditions
- Diet Habit, Rheumatologic Disease, Autoimmune Diseases, Rheumatoid Arthritis
- Trial name
- NCT06339957
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Central Florida
Psoriasis
Evaluation of the Sensitivity and Specificity of a Novel Quality of Life Tool to Assess the Treatment Satisfaction in Psoriasis Patients
The severity of psoriasis can be influenced by a great variety of factors including extent of the disease, lesions location and impact on quality of life.
- Trial name
- PSO-TARGET (NCT04765332)
- Testing
- DLQI and PSO-TARGET QoL grid
- Where
- 27 sites in Belgium, France
- Volunteers
- 143 people
- Sponsor
- Clinact
Inflammation, Psoriasis
First Human Dose Study of Anti-IL-20 in Psoriasis: A Study of Safety, Tolerability and Early Signals of Biologic and Clinical Effects
This trial is conducted in the United States of America (USA). The aim of this clinical trial is evaluate the safety and tolerability of anti-IL-20 in patients with psoriasis and to determine the preliminary efficacy in an…
- Trial name
- NCT01261767
- Testing
- anti-IL-20
- Where
- 16 sites in United States
- Volunteers
- 55 people
- Sponsor
- Novo Nordisk A/S
Psoriasis, Weight Loss
Study of the Effect of Diet in Overweight or Obese Patients With Psoriasis on Light Therapy
The association between psoriasis and obesity has been questioned by physicians for many years. Studies have shown that the risk of having psoriasis is increased in people with a high body mass index, which is a measurement of…
- Conditions
- Psoriasis, Weight Loss, Diet
- Trial name
- NCT00537212
- Testing
- The South Beach Diet, The Ornish Diet, Control Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bagel, Jerry, M.D.
Psoriasis
Roflumilast Versus Methotrexate in Psoriasis
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor, which is approved in its oral form for chronic obstructive pulmonary disease, and in its topical form in the treatment of plaque psoriasis.
- Trial name
- NCT05684744
- Testing
- Roflumilast, Methotrexate
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Nail Psoriasis, Plaque Psoriasis
Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis
The purpose of this study is to evaluate if Etanercept administered at a higher initial dose provides greater improvement in nail and skin psoriasis symptoms than a regimen with a lower initial dose.
- Trial name
- NCT00581100
- Testing
- etanercept
- Volunteers
- 136 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis
Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS
The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection…
- Conditions
- Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT04018599
- Testing
- 40 mg MSB11022
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
Healthy Subjects
Safety Study of BMS-986165 in Healthy Subjects and to Treat Psoriasis
The purpose of this study is to establish if BMS-986165 is safe and effective at treating autoimmune diseases. BMS-986165 which has shown some promise in preclinical studies for inhibiting autoimmune conditions.
- Trial name
- NCT02534636
- Testing
- BMS-986165, Interferon alpha-2a recombinant, Famotidine
- Where
- Australia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Psoriasis
Efficacy and Safety Study of Total Glucosides of Paeony Combined With Acitretin to Treat Psoriasis
This is a randomized, double blind, placebo parallel-controlled, multi-center clinical trial. Patients with psoriasis vulgaris were randomly divided into the experiment group （treated with TGP combined with acitretin capsules)…
- Trial name
- NCT02191020
- Testing
- Total glucosides of paeony & Acitretin Capsules, Acitretin Capsules
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Xijing Hospital
Psoriasis, Diabetes
Comprehensive Intervention of Diabetes and Psoriasis Comorbidity Prevention and Control
We will recruit 300 patients with psoriasis from Yueyang Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, who will not be currently diagnosed with diabetes but will have been identified as…
- Trial name
- NCT06402760
- Testing
- TCM comprehensive treatment, Western medicine
- Volunteers
- 300 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Psoriatic Arthritis
Validation of Handheld Ultrasound Devices in Rheumatology
The goal of this clinical trial is to test the concurrent validity of the Clarius handheld ultrasound devices versus gold-standard device to detect characteristic features of healthy and rheumatic joints in adults Psoriatic…
- Trial name
- NCT06580886
- Testing
- Ultrasound
- Where
- 3 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Psoriasis
An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO)
The IMMagine study aims to validate the newly developed CLCI instrument (DermCLCI-p) in moderate to severe psoriasis (PsO) patients, who will be started on Risankizumb (RZB) treatment and will be enrolled into the validation…
- Trial name
- IMMagine (NCT05959070)
- Where
- 16 sites in Belgium, Canada and 1 more
- Volunteers
- 154 people
- Sponsor
- AbbVie
Psoriasis Vulgaris
LEO 32731 - A Phase I Study in Healthy Subjects
LEO 32731 ("Study Drug") is an investigational drug which is being developed by LEO Pharma A/S ("the Sponsor") for treatment of psoriasis.
- Trial name
- NCT02514694
- Testing
- LEO32731
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Inflammation; Skin, Psoriasis
Pleiotropic Role of TRPV1 in Psoriasis Inflammation
Widely expressed in the sensory nerve endings of the skin, Transient Receptor Potential Vanilloid 1 (TRPV1) is a receptor that plays an important role in the perception of pain and pruritus but also in skin inflammation…
- Trial name
- TRIP (NCT04848194)
- Testing
- skin biopsy and blood sampling
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest
Psoriatic Arthritis
Metformin in Psoriatic Arthritis
Psoriatic arthritis (PsA) is a systemic, inflammatory disease. The chronic inflammation in PsA predisposes patients to the metabolic syndrome (MetS). MetS is associated with systemic inflammation and proinflammatory cytokines.
- Trial name
- NCT02188654
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- University of Alexandria
Psoriatic Plaque
A Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Topical ESR-114 in Subjects With Plaque Psoriasis
This is a multicenter, double-blind, randomized, vehicle-controlled, parallel-group proof-of-concept study designed to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of topically applied ESR-114…
- Trial name
- NCT03630939
- Testing
- ESR-114
- Where
- 10 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Escalier Biosciences B.V.
Arthritis, Psoriatic
A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA).
- Trial name
- VELOTA (NCT07321873)
- Testing
- JNJ-88545223
- Where
- 75 sites in United States, China and 6 more
- Volunteers
- 157 people
- Sponsor
- Janssen Research & Development, LLC
Psoriasis
Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Psoriasis
The study evaluated the efficacy of AMG 827 compared with placebo as measured by the percent of improvement in PASI score at week 12.
- Trial name
- NCT00975637
- Testing
- 70 mg SC, 210 mg SC, 140 mg SC
- Volunteers
- 198 people
- Sponsor
- Bausch Health Americas, Inc.
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