Clinical trials: stroke
Cerebrovascular Accident, Sleep Disorder
Cranial Electrical Stimulation (CES) as Treatment for Insomnia in Patients With Subacute Stroke
This will be a double blinded randomized clinical trial carried out at Zale-Lipshy and Parkland Hospital Inpatient Rehabilitation Facilities.
- Trial name
- NCT03344562
- Testing
- CES
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Texas Southwestern Medical Center
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stroke, Foot Drop
Ankle Robot to Reduce Foot Drop in Stroke
Deficits in ankle control after stroke can lead to foot drop, resulting in inefficient, aberrant gait and an elevated falls risk.
- Trial name
- NCT02483676
- Testing
- Treadmill plus anklebot, Treadmill only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Stroke, Ischemia
Analysis of Revascularization in Ischemic Stroke With EmboTrap
The study objective is to examine the recanalization efficacy of the EmboTrap device and its associated performance characteristics and to record associated clinical outcomes in a manner that facilitates relevant comparison of…
- Trial name
- ARISEII (NCT02488915)
- Testing
- EmboTrap® Revascularization Device
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 228 people
- Sponsor
- Neuravi Inc.
Acute Ischemic Stroke
A Study to Evaluate Safety and PK of Multiple Doses of LT3001 Drug Product and Drug-drug Interaction in Healthy Subjects
This Phase 1 study is planned to establish the clinical safety and pharmacokinetics profile of multiple dose of LT3001 drug product and to investigate drug interactions of LT3001 with potential concomitant medications in healthy…
- Trial name
- NCT04809818
- Testing
- LT3001 drug product, Aspirin, Clopidogrel
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Stroke, Hemiparesis
Effectiveness of Virtual Reality Gaming Therapy Versus CI Therapy for Upper Extremity Rehabilitation
The current proposal aims to conduct a multi-site randomized controlled trial comparing virtual-reality gaming delivery of Constraint Induced Movement therapy (CI therapy) with (1) traditional clinic-based CI therapy of equal…
- Trial name
- NCT02631850
- Testing
- Traditional CI Therapy, Gaming CI Therapy, Gaming CI Therapy with Additional Contact via Video Conference
- Where
- 5 sites in United States
- Volunteers
- 193 people
- Sponsor
- Ohio State University
Cardiovascular Events
A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People
This study was planned to provide new information regarding the role of aliskiren (with or without additional therapy with a diuretic or a Calcium channel blockers (CCB)) in elderly individuals (≥ 65 years) with systolic blood…
- Trial name
- APOLLO (NCT01259297)
- Testing
- Aliskiren, Amlodipine, Hydrochlorothiazide (HCTZ)
- Where
- 185 sites in United States, Argentina and 16 more
- Volunteers
- 2,336 people
- Sponsor
- Novartis Pharmaceuticals
Depression
Spanish Intervention for Caregivers of Veterans With Stroke
This research study will test a problem-solving intervention for Spanish-speaking stroke caregivers that will be delivered over the telephone and online via the previously developed and nationally available Spanish version of the…
- Trial name
- RESCUE (NCT03142841)
- Testing
- RESCUE Problem Solving Intervention
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Shoulder Pain Chronic
An Implantable Microneuromodulator for the Treatment of Chronic Shoulder Pain in Chronic Post-Stroke Subjects
The goal of this research study is to investigate safety and gather initial effectiveness data for a new implanted device designed to treat chronic shoulder pain in chronic post-stroke subjects.
- Trial name
- BBPM (NCT00567541)
- Testing
- Battery Powered Microneuromodulator (BBPM)
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Bioness Inc
Stroke, Intracranial Hypotension
Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access
Hypertonic saline is used to treat elevated intracranial pressure. Intraosseous vascular access has been used to administer fluids and medications. This study combines these to administer 3% hypertonic saline via IO.
- Conditions
- Stroke, Intracranial Hypotension, Cerebral Edema
- Trial name
- NCT03276494
- Testing
- Intraosseous, Hypertonic saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Stroke, Myocardial Infarction
Insulin Resistance Intervention After Stroke Trial
The purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.
- Conditions
- Stroke, Myocardial Infarction, Diabetes
- Trial name
- IRIS (NCT00091949)
- Testing
- pioglitazone
- Where
- 183 sites in United States, Australia and 6 more
- Volunteers
- 3,876 people
- Sponsor
- Yale University
Vertebral Artery Dissection, Cerebrovascular Accident
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
The Investigators are performing a study to determine, in patients with chronic/recurrent neck pain, the cerebrovascular hemodynamic consequences of cervical spine movements, including manipulation, in vivo using fMRI technology…
- Conditions
- Vertebral Artery Dissection, Cerebrovascular Accident, Stroke
- Trial name
- NCT02667821
- Testing
- Head positions and spinal manipulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Canadian Memorial Chiropractic College
Stroke, Hemiparesis
Long Term Split Belt Treadmill Training for Stroke Recovery
The purpose of this study is to determine whether split belt or conventional treadmill training can be used to treat walking pattern deficits from stroke and to determine whether this improves gait asymmetry and metabolic…
- Trial name
- NCT01646216
- Testing
- Split belt treadmill
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Stroke, Stroke Sequelae
Mindfulness Based Stress Reduction and Post-Stroke Cognition
The investigators don't fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to…
- Conditions
- Stroke, Stroke Sequelae, Depression, Cognitive Impairment
- Trial name
- NCT04302493
- Testing
- Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Stroke, Hemiparesis
Electrical Stimulation for Recovery of Hand Function in Chronic Stroke Survivors
Impaired hand function is one of the most frequently persisting consequences of stroke. The purpose of this study is to compare two different treatments -- Contralataterally Controlled Functional Electrical Stimulation (CCFES)…
- Conditions
- Stroke, Hemiparesis, Hemiplegia
- Trial name
- NCT00891319
- Testing
- Electrical stimulator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- MetroHealth Medical Center
Acute Stroke
Metabolic Costs of Walking Post Stroke
This will be a randomized, matched-group study to compare the cardiopulmonary / metabolic benefits for persons post stroke that learn to walk utilizing early treadmill training post-acute stroke to persons post stroke that learn…
- Trial name
- NCT02108912
- Testing
- ESTT, Traditional outpatient
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center
Cerebral Stroke, Hemiplegia, Spastic
The Effects of Reaching Task Following Selective Trunk Stability Exercise
This study is performed in a controlled randomized, two-period crossover design to test the efficacy of Abdominal drawing-in maneuver (ADIM) exercise compared to conventional physiotherapy in chronic stroke survivors.
- Trial name
- NCT05767437
- Testing
- Abdominal drawing-in maneuver exercise
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- University of Valencia
Cerebrovascular Accident, Moyamoya Disease
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya disease and stroke patients
- Trial name
- NCT01419275
- Testing
- Xenon contrast agent, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Stanford University
Post-Stroke Spasticity, Cerebrovascular Accident
Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity
This is a study to confirm the superior efficacy of a single treatment of GSK1358820 over placebo in patients with post-stroke upper limb spasticity of both the wrist and finger flexors using the Modified Ashworth Scale (MAS)…
- Trial name
- NCT00460564
- Testing
- GSK1358820
- Where
- 18 sites in Japan
- Volunteers
- 109 people
- Sponsor
- GlaxoSmithKline