Clinical trials: stroke
Stroke, Stroke, Ischemic
Passive Tactile Stimulation for Stroke Rehabilitation
Stroke can lead to weakness and spasticity in the arm or hand. The purpose of this study is to optimize the design of gentle vibratory stimulation delivered to the hands of individuals with chronic stroke, and explore the effect…
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- PTS (NCT03814889)
- Testing
- Vibration pattern, No vibration
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Stroke
Treatment of Chronic Stroke With IpsiHand
The ultimate goal of this project is to develop a functioning and clinically feasible method for restoring function to motor-impaired stroke survivors. This ultimate goal will be approached through two different means.
- Trial name
- NCT02552368
- Testing
- IpsiHand Device
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Carotid Artery Disease
Proximal Protection With The Mo.Ma Device During Carotid Stenting
The objective of the ARMOUR study is to evaluate the safety and effectiveness of the Mo.Ma proximal flow blockage cerebral protection device for patients at high surgical risk for carotid endarterectomy who undergo carotid artery…
- Trial name
- ARMOUR (NCT00744523)
- Testing
- Mo.Ma cerebral protection device
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- Medtronic Endovascular
Pediatric Stroke, Cerebral Palsy
Repetitive TMS and Occupational Therapy in Children and Young Adults With Chronic Hemiparesis
The purpose of this study is to determine whether Repetitive Transcranial Magnetic Stimulation (rTMS) can augment occupational therapy in improving motor function in children (10 years of age or older) and young adults (< 21…
- Conditions
- Pediatric Stroke, Cerebral Palsy, Chronic Hemiparesis
- Trial name
- NCT02057276
- Testing
- Repetitive Transcranial Magnetic Stimulation, Occupational Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Acute Ischemic Stroke
Multi-arm Optimization of Stroke Thrombolysis
The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results…
- Trial name
- MOST (NCT03735979)
- Testing
- Argatroban, Eptifibatide
- Where
- 61 sites in United States
- Volunteers
- 514 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
Chronic Stroke
Post-Stroke Walking Speed and Community Ambulation Conversion Study
The purpose of this randomized, controlled study is to collect performance data on the ability of an investigational device designed to digitally deliver Rhythmic Auditory Stimulation to improve walking speed in people who…
- Trial name
- NCT04121754
- Testing
- MR-001, Active Walking
- Where
- 8 sites in United States
- Volunteers
- 87 people
- Sponsor
- MedRhythms, Inc.
Stroke, Acute
Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke
This study will assess the potential efficacy and safety of TSC as early treatment for both ischemic and hemorrhagic stroke when administered while subject is in ambulance being transported to hospital.
- Trial name
- PHAST-TSC (NCT03763929)
- Testing
- Trans-Sodium Crocetinate
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Ischemic Stroke, Biofeedback
Effects of Biofeedback in Patients With Acute Cerebral Infarction
The major aim of this study is to investigate the effects of biofeedback assisted abdominal breathing training on improving the psychological and physiological distress in patients with ACI.
- Conditions
- Acute Ischemic Stroke, Biofeedback, Autonomic Dysfunction, Cognitive Function, Psychological Distress
- Trial name
- NCT03516227
- Testing
- heart rate variability biofeedback
- Volunteers
- 40 people
- Sponsor
- National Defense Medical Center, Taiwan
Atrial Fibrillation
A Phase III Study of Apixaban in Patients With Atrial Fibrillation
The purpose of this clinical research study is to determine whether apixaban is more effective than acetylsalicylic acid in the prevention of strokes associated with patients with atrial fibrillation.
- Trial name
- AVERROES (NCT00496769)
- Testing
- Apixaban, Acetylsalicylic acid
- Where
- 503 sites in United States, Argentina and 34 more
- Volunteers
- 6,421 people
- Sponsor
- Bristol-Myers Squibb
Stroke
Stroke Self-Management: Effect on Function and Stroke Specific Quality of Life
The experience of a stroke event may result in a disruption to the survivor's daily life. Patients with stroke have reported fears of permanent disability and major concerns over their ability to recover and be productive and…
- Trial name
- NCT01507688
- Testing
- Stroke Self-Management
- Where
- 2 sites in United States
- Volunteers
- 258 people
- Sponsor
- VA Office of Research and Development
Stroke, CVA
Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke.
PURPOSE: The purpose of this study will be to identify whether patients in the subacute stage of stroke, who demonstrate foot drop, will have better gait outcomes when using a Double Adjustable AFO, or a Posterior Leaf Spring…
- Conditions
- Stroke, CVA, Hemiplegia, Hemiparesis
- Trial name
- NCT02693834
- Testing
- Posterior Leaf spring AFO, Double adjustable AFO
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Texas Woman's University
Stroke
Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation
Stroke is a leading cause of morbidity in the United States but identification of treatment strategies to improve outcome is limited by the incomplete understanding of the mechanisms of recovery.
- Trial name
- NCT01569607
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Cathrin Buetefisch
Stroke Induced Vision Loss, Hemianopia
Visual Restoration for Hemianopia
The purpose of this research is to assess the efficacy of a visual training task on reducing the size of a visual field deficit caused by brain damage in adults, and its ability to improve visual functions in this patient…
- Conditions
- Stroke Induced Vision Loss, Hemianopia, Quadrantanopia
- Trial name
- NCT03350919
- Testing
- Training in the blind field, Training in the intact field
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Rochester
Stroke
Sensory Augmentation Methods in Stroke
Many chronic stroke survivors have poor walking balance, contributing to an increased risk of falls and fear of falling. One factor contributing to these balance deficits is a reduced ability to place the feet appropriately when…
- Trial name
- SAM (NCT03988400)
- Testing
- Sensory Augmentation, Random Vibration
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Stroke
Neurophysiological and Kinematic Predictors of Response in Chronic Stroke
The purpose of this study is to design a predictive model of stroke recovery based on baseline measurements of arm movement and brain physiology.
- Trial name
- SRT4 (NCT02658630)
- Testing
- Robot + TTT exercise
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- VA Office of Research and Development