Clinical trials: stroke
Stroke-related Pneumonia
Microbe-host Interaction Relationship in Patients With Stroke-relatedPneumonia
This study intends to use a standardized cohort study to collect biological samples (including throat swabs, sputum and blood) from subjects eligible for inclusion, and use 16s DNA / metagenomic sequencing and metabolome…
- Trial name
- NCT06161298
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Cancer- and Cancer Treatment-Related Conditions, Stroke
Studies on the Impact of Taste-aware Intelligent Analysis of Oral Nutritional Supplements
The goal of this observational study is to test the taste perception threshold and palatability interval of different populations and the difference in taste perception between tumor and stroke patients and healthy people by…
- Trial name
- NCT05651321
- Testing
- Samples materials of basic taste stimuli and enteral nutrition preparations
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Stroke
Effects of Mirror Therapy and Motor Imagery on Upper Limb Motor Functions in Middle Cerebral Artery Stroke
This study will compare mirror therapy (MT) with motor imagery (MI), each added to routine Bobath-based physical therapy, to assess upper limb motor function and functional independence in patients with subacute middle cerebral…
- Trial name
- NCT07902284
- Testing
- Mirror Therapy, Motor Imagery, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Stroke
Effects of Early Exercise in Patients With Moderate to Severe Stroke.
Purpose: to investigate the efficacy of early exercise in patients with moderate to severe stroke regarding functional outcome and walking ability.
- Trial name
- NCT04241952
- Testing
- Exercise
- Volunteers
- 52 people
- Sponsor
- Klas Sandberg
Hemispatial Neglect, Hemiplegia
The Effects of Offline Anosognosia For Spatial Neglect on Neglect Rehabilitation
Anosognosia for hemispatial neglect is an intriguing phenomenon characterized by decreased awareness of spatial deficits, common in patients with right hemisphere stroke.
- Conditions
- Hemispatial Neglect, Hemiplegia, Right Hemispheric Stroke, Anosognosia
- Trial name
- NCT05145855
- Testing
- Patient-tailored multimodal neglect rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Gazi University
Stroke, Knowledge, Attitudes, Practice
Effects of an Educational Intervention on Rehabilitation Clinicians' Practices for Health-related Outcomes After Stroke
The overall aim of this pilot study is to evaluate the feasibility of a study protocol for a future stepped wedge cluster randomized clinical trial (c-RCT) that will investigate the effects of an innovative KT intervention on 1)…
- Conditions
- Stroke, Knowledge, Attitudes, Practice, Physical Disability, Motor Skills Disorders
- Trial name
- NCT03807115
- Testing
- Implementation of stroke mobility guidelines
- Where
- 6 sites in Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McGill University
Acute Ischemic Stroke
Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke
To assess the safety and efficacy of beyond time window TNK intravenous thrombolysis for distal Medium Vessel Occlusion (MeVO) related stroke in a prospective randomized clinical trial.
- Trial name
- NCT06559436
- Testing
- Intravenous thrombolysis, Standard medical management
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke
Effects of Oropharyngeal Strengthening on Dysphagia in Patients Post-stroke
The overall goal of this randomized controlled pilot study is to characterize effects of SwallowSTRONG® Device-Facilitated Isometric Progressive Resistance Oropharyngeal (DF I-PRO) therapy in a dose response framework on…
- Trial name
- StrokeStrong (NCT02322411)
- Testing
- Isometric Progressive Resistance Oropharyngeal Therapy, Compensatory approaches
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Stroke
Balance Training After Stroke - a Randomized, Controled Pilot Study
This pilot study is part of a master's thesis. In the rehabilitation of stroke patients should be compared whether individual balance training has a greater effect than group balance training.
- Trial name
- NCT03791671
- Testing
- individual balance training, group balance training
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- RehaClinic AG
Stroke
Mirror Therapy: Effects on Functional Recuperation of Severe Upper Limb Paresis After Stroke
After stroke, patients frequently suffer from arm or hand weakness. There are numerous rehabilitation methods to stimulate recovery, amongst which mirror therapy (MT).
- Trial name
- MT (NCT02949609)
- Testing
- Mirror Therapy, Control Therapy
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Geneva
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Acute Stroke, Cerebral Ischemia
PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients
This was a prospective, multicentric, randomized, double blind, parallel, saline controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 (INN: Sovateltide) therapy along with standard supportive care in…
- Trial name
- NCT04046484
- Testing
- Normal Saline along with standard treatment, PMZ-1620 along with standard treatment
- Where
- 7 sites in India
- Volunteers
- 40 people
- Sponsor
- Pharmazz, Inc.
Stroke, Subarachnoid Hemorrhage
Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation
Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of…
- Trial name
- GAS-SAH (NCT00830843)
- Testing
- Propofol, Isoflurane
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Stroke
A Trial of Nature-based Post-stroke Fatigue Rehabilitation (NASTRU)
The aim of NASTRU was to examine whether ten weeks of nature-based rehabilitation, as add-on to standard management, could influence post-stroke fatigue (primary outcome), depression, work ability or functional outcome (secondary…
- Trial name
- NASTRU (NCT02435043)
- Testing
- Nature based rehabilitation, standard management after stroke
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Region Skane
Ischemic Stroke
The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke
The primary objective of the trial is to establish the effectiveness of IAT (versus medical management) in patients with moderate-large infarcts (NCCT ASPECTS 2-5) at baseline, with adaptive enrichment to better define the upper…
- Trial name
- TESLA (NCT03805308)
- Testing
- Intra-arterial Therapy
- Where
- 43 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mercy Health Ohio
Post-stroke Depression
Intervention Study of Virtual Reality-Based Mindfulness-Based Cognitive Therapy (VR-MBCT) Combined With Adaptive tDCS Modulation for Post-Stroke Depression
This study investigates whether combining virtual reality mindfulness-based cognitive therapy (VR-MBCT) with transcranial direct current stimulation (tDCS) can effectively treat depression occurring after a stroke (post-stroke…
- Trial name
- NCT07422740
- Testing
- Virtual Reality Mindfulness-Based Cognitive Therapy (Active VR-MBCT), Active transcranial Direct Current Stimulation (Active tDCS)
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Post-stroke Cognitive Impairment (PSCI)
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
Post-stroke cognitive impairment (PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for at least 24 weeks.
- Trial name
- Be-CLEVER (NCT05976152)
- Testing
- dl-3-butylphthalide
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- Fudan University
Acute Ischemic Stroke
Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke
Time is one of the most important in the decision of treatment of acute ischemic stroke. The optimal One-stop management from admission to recanalization associated with reduction of in-hospital times.
- Trial name
- ORETOM (NCT05644938)
- Testing
- Standard workflow, One-stop
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Stroke, Intracranial Atherosclerosis
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology.
- Trial name
- STAMINA-MRI (NCT02458755)
- Testing
- High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Stroke, Ischemic, Intracranial Atherosclerosis
Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFR
This multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of ICAS patients divided hemodynamically by Magnetic Resonance Fractional Flow…
- Trial name
- NCT06196398
- Testing
- Standard Medical Treatment on the basis of anti-platelet therapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing