Clinical trials: stroke
Stroke, Hyperglycemia
Glucose Regulation in Acute Stroke Patients (GRASP) Study
The purpose of this study is to assess the feasibility, safety and preliminary efficacy of the use of insulin infusions as treatment for hyperglycemic acute ischemic stroke patients.
- Trial name
- NCT00282867
- Testing
- IV glucose insulin and potassium, GIK, standard care
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of Virginia
Chronic Kidney Diseases, Heart Attack
Chronic Kidney Disease (CKD) Platelet Study
This study evaluates how aspirin, clopidogrel and ticagrelor work in people with chronic kidney disease (CKD) compared to people with normal kidneys.
- Conditions
- Chronic Kidney Diseases, Heart Attack, Stroke, Ischemic
- Trial name
- NCT03649711
- Testing
- Ticagrelor 90mg, Clopidogrel 75mg, Aspirin 81 mg
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Ischemic Stroke
Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO)
To determine the revascularization rate of the CE-marked Trevo device in large vessel occlusions in ischemic stroke patients. Revascularization, defined as at least TICI 2a in the vascular territory treated at end of the neuro…
- Trial name
- TREVO (NCT01088672)
- Testing
- Mechanical Thrombectomy
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Stryker Neurovascular
Rehabilitation, Recovery of Function
Functional Viability Duck Duck Punch
This study has 2 parts: In one part of this study, people with stroke will either play a custom designed computer game for stroke rehabilitation called Duck Duck Punch or an off the shelf computer game with their weaker arm 3…
- Conditions
- Rehabilitation, Recovery of Function, Stroke
- Trial name
- DDPSBIR (NCT03053492)
- Testing
- Duck Duck Punch Play, Commercially Available Game Play
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Medical University of South Carolina
Ischemic Stroke, Obstructive Sleep Apnea
Nasal EPAP for Stroke Patients With Sleep Apnea: a Pilot Trial.
Specific aim: To test the effects of nasal expiratory positive airway pressure (EPAP) therapy on sleep apnea severity among patients with recent ischemic stroke.
- Trial name
- NCT01703663
- Testing
- EPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Atrial Fibrillation
Dabigatran Etexilate for Stroke Prevention in Patients With Atrial Fibrillation and Mild to Moderate Renal Impairment
Non-interventional, observational study of physicians' use of Dabigatran etexilate for stroke prevention in patients with atrial fibrillation and mild to moderate renal impairment
- Trial name
- NCT01721837
- Where
- 1,616 sites in Germany
- Volunteers
- 4,340 people
- Sponsor
- Boehringer Ingelheim
Acute Stroke, Stroke, Ischemic
Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania
This is a phase II, randomized study of 120 adults age 18 or above who will prescribed 20mg daily Fluoxetine for 90 days following acute, ischemic stroke.
- Trial name
- MAMBO (NCT03728153)
- Testing
- Fluoxetine 20 MG Oral Tablet
- Where
- Tanzania
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Acute Ischemic Stroke
Enoxaparin and/or Minocycline in Acute Stroke
The purpose of this study is to investigate whether enoxaparin, minocycline, or both medications in combination may help in recovery from acute stroke.
- Trial name
- NCT00836355
- Testing
- Enoxaparin, Minocycline
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Sleep Apnea, Stroke
Positional Therapy After Stroke
Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Unfortunately, there are few therapies that have been proven to improve stroke outcome.
- Trial name
- NCT01047709
- Testing
- Positional therapy including the use of a special pillow
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Fabry Disease
Replagal Enzyme Replacement Therapy for Children With Fabry Disease
Primary Objective(s): To assess the safety of Replagal at a dose of 0.2 mg/kg administered over 40 (+/-10) minutes in children with Fabry disease To assess the effect of Replagal on heart rate variability in patients 7 to 17…
- Trial name
- NCT00084084
- Testing
- Agalsidase alfa
- Where
- 14 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Shire
Ischemic Stroke
Study to Test Sensitivity and Specificity of Passive Wave Pressure Device in Determining Ischemic Stroke
That the Jan Medical Nautilus NeuroWaveTM system provides significantly higher sensitivity to hyper acute ischemic stroke than does CT.
- Trial name
- NCT01643525
- Testing
- Nautilus NeuroWaveTM System
- Where
- 3 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Ischemic Stroke
Bolus of Saline in Stroke
This study is a non-randomized, Phase 2 clinical trial designed to assess optical cerebral blood flow (CBF) response to bolus normal saline. Subjects will have had an ischemic stroke within 96 hours of enrollment.
- Trial name
- BOSS (NCT01971463)
- Testing
- Normal saline
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation, Atrial Flutter
Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk…
- Trial name
- ARISTOTLE (NCT00412984)
- Testing
- warfarin, apixaban
- Where
- 1,111 sites in United States, Argentina and 39 more
- Volunteers
- 20,976 people
- Sponsor
- Bristol-Myers Squibb
Stroke
Effect of Robot Rehabilitation Exercise Training on Motor Control After Stroke
Stroke is a leading cause of neurological disability worldwide, often causing significant weakening and paresis of the affected arm. National spending on post-stroke rehabilitation is project to expand 20% to 35% through 2010.
- Trial name
- NCT02331407
- Testing
- Robotic arm therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Columbia University
Hypertension, Diabetes
Anglo-Scandinavian Cardiac Outcomes Trial: Post Trial Follow-Up Study
ASCOT-10 is a follow-up study of surviving participants in the United Kingdom (UK)arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) which was conducted between 2000 and 2005.ASCOT's results showed substantial…
- Conditions
- Hypertension, Diabetes, Death From Cardiovascular Disease, Myocardial Infarction
- Trial name
- ASCOT-10 (NCT01499511)
- Where
- United Kingdom
- Volunteers
- 1,718 people
- Sponsor
- Imperial College London
Stroke
Mindfulness-Based Stress Reduction to Improve Neuropsychological Functioning in Acquired Brain Injury
Thousands of Veterans suffer a stroke every year, and these individuals often suffer emotional and cognitive changes that negatively affect their quality of life as well as their ability to recover.
- Trial name
- NCT03969563
- Testing
- Mindfulness-based Stress Reduction, Brain Health Education
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Ischemic Stroke
Randomized, Controlled Trial of Extended-Release Niacin (Niaspan®) to Augment Subacute Ischemic Stroke Recovery
The purpose of this study is to determine the safety, tolerability, and to explore the possible benefit of extended-release niacin (Niaspan®) in attempting to improve the recovery of patients after ischemic stroke.
- Trial name
- NCT00796887
- Testing
- Extended-Release Niacin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Henry Ford Health System
Stroke, Hemiplegia
Usability Testing of Affordable Haptic Robots for Stroke Therapy
Stroke survivors with hemiplegia will be evaluated by rehabilitation professionals and asked to perform a battery of assessments to test the viability and usability of a force-feedback robot that adapts to each individual…
- Trial name
- Theradrive (NCT02772809)
- Testing
- Haptic Robot Therapy with Games
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Stroke, Cerebrovascular Accident
Clinic-Based AMES Treatment of Stroke
This study investigates whether assisted movement with biofeedback and muscle vibration applied to the lower limb reduces impairment and improves gait.
- Trial name
- NCT00847704
- Testing
- Assisted movement and enhanced sensation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Oregon Health and Science University
Stroke
Transcranial Direct Current Stimulation for Post-Stroke Aphasia
This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and…
- Trial name
- NCT02461355
- Testing
- Aphasia therapy, Anodal tDCS
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University