Clinical trials: tDCS Mechanisms
Stroke, Brain Injuries
Brain Mechanisms Underlying Reading Improvement in Central Alexia
Central alexia is a common reading disorder caused by stroke. Patients with central alexia (CA) are slow to read and make frequent errors, and have additional problems with their spoken language. This study has 3 aims: 1.
- Conditions
- Stroke, Brain Injuries, Aphasia
- Trial name
- NCT02062619
- Testing
- Computer-based behavioural word reading therapy, Real tDCS
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Cerebral Palsy, Hemiplegic
Cerebral pAlsy Motor Promotion With Transcranial Direct Current Stimulation (CAMP-tDCS)
This study aims to test if transcranial direct current stimulation (tDCS) can be applied to boost the efficacy of constraint-induced movement therapy (CIMT) in children with HCP and examine brain mechanisms related to individual…
- Trial name
- NCT06239675
- Testing
- tDCS, CIMT
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Stroke
Brain Stimulation-aided Stroke Rehabilitation: Neural Mechanisms of Recovery
The purpose of this study is to investigate whether benefits of training the affected hand in patients with stroke can be improved by combining training with a painless, noninvasive technique called Transcranial Direct Current…
- Trial name
- NCT01539096
- Testing
- tDCS: noninvasive brain stimulation, Constraint induced movement therapy (CIMT)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Aphasia
Treatment Outcomes With tDCS in Post-Stroke Aphasia
The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery.
- Trial name
- NCT03929432
- Testing
- Active Transcranial Direct Current Stimulation with SLT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Healthy Young and Older Adults
Mechanism of tDCS-induced Learning Enhancement - the Role of Serotonin
The aim of this study is to assess whether the application of a selective serotonin reuptake inhibitor (SSRI) enhances and prolongs the learning enhancement achieved by anodal transcranial direct current stimulation (atDCS).
- Trial name
- LESO (NCT02092974)
- Testing
- tDCS, Citalopram
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Post-stroke Aphasia
Efficacy and Neural Mechanisms of Transcranial Direct Current Stimulation Targeting the Supplementary Motor Area for the Treatment of Subacute Post-stroke Aphasia
This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) in patients with post-stroke aphasia (PSA) and to explore its potential neural mechanisms.
- Trial name
- NCT07700537
- Testing
- transcranial direct current stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Primary Progressive Aphasia
Treating Primary Progressive Aphasia (PPA) Using tDCS
This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and semantic variants of primary progressive aphasia (naPPA and svPPA, respectively) will undergo language testing and…
- Trial name
- NCT04566731
- Testing
- Transcranial Direct Current Stimulation (tDCS), Modified Contraint-Induced Language Therapy (mCILT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
tDCS Mechanisms
Understanding the Neural Mechanisms Behind tDCS
The aim of the study is to investigate the neural mechanisms underpinning transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique in which a direct current is passed through scalp electrodes.
- Trial name
- NCT04577677
- Testing
- brain stimulation
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Transcranial Direct Current Stimulation (tDCS), Breast Cancer Survivor
Transcranial Direct Current Stimulation for Cancer-related Cognitive Impairment in Breast Cancer Survivors
This study aims to evaluate the efficacy of transcranial direct current stimulation (tDCS) in improving cancer-related cognitive impairment (CRCI) in breast cancer survivors.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Breast Cancer Survivor, Cognitive Impairment
- Trial name
- NCT07083518
- Testing
- Anodal transcranial direct current stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Dysphagia After Stroke
Cerebellar Transcranial Direct Current Stimulation for Dysphagia After Supratentorial Stroke
It is estimated that 400,000 to 800,000 people worldwide develop neurogenic dysphagia annually. Stroke represents the most common etiology, with approximately 65% of acute stroke patients experiencing pharyngeal swallowing…
- Trial name
- NCT07212634
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 76 people
- Sponsor
- Zhejiang Provincial People's Hospital
Cerebrovascular Accident
Neural Mechanisms and Efficacy of Dual Neurotechnology-aided Mirror Therapy in Chronic Stroke: Neural and Motor Plasticity, Movement Performance, Daily Function, and Quality of Life
Mirror therapy (MT) has been demonstrated, in terms of neuroplasticity, to improve sensorimotor function of paretic upper extremity (UE) in chronic stroke patients.
- Trial name
- NCT04326205
- Testing
- transcranial direct current stimulation, tDCS, functional electrical stimulation, FES, no stimulation
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, tDCS
Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke
This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke.
- Conditions
- Stroke, tDCS, Action Observation Therapy, Hand
- Trial name
- NCT07400939
- Testing
- tDCS, Action Observation Therapy (AOT)
- Where
- 2 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Malaysia Sabah
Chronic Widespread Pain, Fibromyalgia (FM)
The Added Value of Transcranial Direct Current Stimulation (tDCS) During Exercise for People With Chronic Widespread Pain
Many people with chronic widespread pain (CWP) feel more pain and fatigue after exercise. This makes it hard to stay active. Unfortunately, the investigators do not fully understand why this happens and how to prevent it.
- Trial name
- NCT07212829
- Testing
- Active tDCS, Aerobic exercise
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Itching Symptoms, Itching Caused by Epidural Use of Opioids
tDCS for Reducing the Incidence of OEI After Cesarean Section
Cesarean section is the most common obstetric surgery worldwide. Epidural anesthesia has become the preferred anesthesia method for cesarean sections due to its definite analgesic effect and minimal impact on mother and baby.
- Trial name
- NCT07569783
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Affiliated Hospital of Nantong University
Fibromyalgia, Food Addiction
Effect of Transcranial Direct-current Stimulation in Eating Behavior of Women With Fibromyalgia
Introduction: Fibromyalgia (FM) is a syndrome characterized by generalized musculoskeletal pain, fatigue, non-repairing sleep, cognitive changes, depressive symptoms and other correlates of autonomic dysfunction.
- Trial name
- NCT04192058
- Testing
- Active transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Spinal Cord Injury
Application of Transcranial Direct Current Stimulation (tDCS) in Patients With Chronic Pain After Spinal Cord Injury
The purpose of this study is to determine whether the novel treatment of transcranial direct current stimulation (tDCS) could decrease the pain perception of those with spinal cord injury.
- Trial name
- NCT01112774
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Disorder of Consciousness
HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is…
- Trial name
- HD-tDCS (NCT05285124)
- Testing
- Melatonin, HD-tDCS
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Transcranial Direct Current Stimulation
Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods
In this study the investigators will explore dosimetry in transcranial electrical stimulation using a novel magnetic resonance imaging technique that can determine how electrical stimulation distributes within the brain.
- Trial name
- TES (NCT03772210)
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Arizona State University